(Q52675363)

5 May 2018

title

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. (English)

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5 May 2018

Tudor A Fulga

1

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Tara L Spires-Jones

object named as

Tara L Spires

5

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Bradley Hyman

6

object named as

Bradley T Hyman

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5 May 2018

Ilan Elson-Schwab

2

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5 May 2018

Vikram Khurana

3

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5 May 2018

Michelle L Steinhilb

4

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5 May 2018

Mel B Feany

7

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5 May 2018

publication date

24 December 2006

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5 May 2018

published in

Nature Cell Biology

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5 May 2018

volume

9

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5 May 2018

page(s)

139-148

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5 May 2018

issue

2

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5 May 2018

https://scigraph.springernature.com/pub.10.1038/ncb1528

exact match

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cites work

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

1 reference

7 January 2021

Neurodegenerative tauopathies

1 reference

7 January 2021

Microfilament-associated growth cone component depends upon Tau for its intracellular localization

1 reference

7 January 2021

Subpopulations of tau interact with microtubules and actin filaments in various cell types.

1 reference

7 January 2021

Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner

1 reference

7 January 2021

Microtubule-associated protein 2c reorganizes both microtubules and microfilaments into distinct cytological structures in an actin-binding protein-280-deficient melanoma cell line

1 reference

7 January 2021

The tubulin-binding sequence of brain microtubule-associated proteins, tau and MAP-2, is also involved in actin binding

1 reference

7 January 2021

A tau fragment containing a repetitive sequence induces bundling of actin filaments.

1 reference

7 January 2021

Tubulin, actin, and tau protein interactions and the study of their macromolecular assemblies.

1 reference

7 January 2021

MAP2c, but not tau, binds and bundles F-actin via its microtubule binding domain

1 reference

7 January 2021

Fine structure of the Pick and Hirano bodies in a case of Pick's disease.

1 reference

7 January 2021

The Association of Actin with Hirano Bodies

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7 January 2021

Hirano body filaments contain actin and actin-associated proteins

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7 January 2021

Hirano bodies and related neuronal inclusions

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7 January 2021

A role for the actin cytoskeleton in cell death and aging in yeast.

1 reference

7 January 2021

Inhibition of apoptosis by the actin-regulatory protein gelsolin

1 reference

7 January 2021

Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release

1 reference

7 January 2021

Mitochondrial translocation of cofilin is an early step in apoptosis induction.

1 reference

7 January 2021

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

1 reference

7 January 2021

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

1 reference

7 January 2021

Modelling neurodegenerative diseases in Drosophila: a fruitful approach?

1 reference

7 January 2021

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila.

1 reference

7 January 2021

A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration

1 reference

7 January 2021

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

1 reference

7 January 2021

Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

1 reference

7 January 2021

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

1 reference

7 January 2021

Tau suppression in a neurodegenerative mouse model improves memory function

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7 January 2021

Cofilin changes the twist of F-actin: implications for actin filament dynamics and cellular function

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7 January 2021

Hirano bodies contain tau protein.

1 reference

7 January 2021

Two actin binding proteins, actin depolymerizing factor and cofilin, are associated with Hirano bodies

1 reference

7 January 2021

Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy

1 reference

7 January 2021

TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

1 reference

7 January 2021

One of the two cytoplasmic actin isoforms in Drosophila is essential

1 reference

7 January 2021

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

7 January 2021

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

7 January 2021

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

7 January 2021

A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster.

1 reference

7 January 2021

Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases

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7 January 2021

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

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7 January 2021

Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization

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7 January 2021

Oxidative stress signalling in Alzheimer's disease

1 reference

7 January 2021

Conserved microtubule-actin interactions in cell movement and morphogenesis

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7 January 2021

Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin

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7 January 2021

Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis

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7 January 2021

Oxidative stress mediates tau-induced neurodegeneration in Drosophila

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7 January 2021

Identifiers

DOI

10.1038/NCB1528

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5 May 2018

PubMed ID

17187063

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5 May 2018