(Q44805871)

6 December 2017

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title

Neurodegenerative diseases and oxidative stress (English)

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6 December 2017

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3

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6 December 2017

2

Colin L Masters

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6 December 2017

1

Kevin J Barnham

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6 December 2017

publication date

1 March 2004

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Nature Reviews Drug Discovery

6 December 2017

published in

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6 December 2017

volume

3

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6 December 2017

issue

3

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6 December 2017

page(s)

205-214

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The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease.

6 December 2017

cites work

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Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death

31 March 2020

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Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

31 March 2020

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Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

31 March 2020

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Lipid peroxidation in neurodegeneration: new insights into Alzheimer's disease

31 March 2020

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Chemistry and biochemistry of oxidative stress in neurodegenerative disease

31 March 2020

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Increased nuclear DNA oxidation in the brain in Alzheimer's disease

31 March 2020

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Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra

31 March 2020

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Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation

31 March 2020

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Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures

31 March 2020

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Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

31 March 2020

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H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK.

31 March 2020

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Calcium and oxidative stress: from cell signaling to cell death

31 March 2020

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Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease

31 March 2020

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Interactions of oxidative stress with cellular calcium dynamics and glucose metabolism in Alzheimer's disease

31 March 2020

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Neuronal and glial calcium signaling in Alzheimer's disease

31 March 2020

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The hydroxyl radical scavenger Nicaraven inhibits glutamate release after spinal injury in rats

31 March 2020

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Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders

31 March 2020

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Free radical pathways in CNS injury

31 March 2020

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Oxidants as stimulators of signal transduction

31 March 2020

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Hydrogen peroxide signalling

31 March 2020

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The effect of aging on the mineral status of female mice

31 March 2020

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31 March 2020

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Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

31 March 2020

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31 March 2020

Metals and neuroscience.

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The metallobiology of Alzheimer's disease

31 March 2020

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Amyloid, the presenilins and Alzheimer's disease

31 March 2020

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Alzheimer's disease: genetic studies and transgenic models

31 March 2020

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

31 March 2020

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

31 March 2020

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

31 March 2020

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Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

31 March 2020

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Copper, iron and zinc in Alzheimer's disease senile plaques

31 March 2020

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Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

31 March 2020

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Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

31 March 2020

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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

31 March 2020

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Increased cerebral glucose-6-phosphate dehydrogenase activity in Alzheimer's disease may reflect oxidative stress

31 March 2020

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In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

31 March 2020

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Elevation of serum copper levels in Alzheimer's disease

31 March 2020

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Iron: a pathological mediator of Alzheimer disease?

31 March 2020

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Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine

31 March 2020

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Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

31 March 2020

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Hydrogen peroxide mediates amyloid beta protein toxicity

31 March 2020

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

31 March 2020

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Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

31 March 2020

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

31 March 2020

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Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

31 March 2020

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Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

31 March 2020

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Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid

31 March 2020

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Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

31 March 2020

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Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

31 March 2020

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Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome

31 March 2020

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

31 March 2020

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Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion

31 March 2020

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Magnetic Resonance Studies of β-Amyloid Peptides

31 March 2020

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Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β

31 March 2020

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α-Synuclein in Lewy bodies

31 March 2020

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Genetics of Parkinson's disease

31 March 2020

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Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

31 March 2020

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The structure of neuromelanin as studied by chemical degradative methods

31 March 2020

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Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour

31 March 2020

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Iron-binding characteristics of neuromelanin of the human substantia nigra.

31 March 2020

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On the functional of neuromelanin.

31 March 2020

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Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles.

31 March 2020

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Iron-melanin interaction and lipid peroxidation: implications for Parkinson's disease

31 March 2020

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Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease.

31 March 2020

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Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line

31 March 2020

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Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease

31 March 2020

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Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress

31 March 2020

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A role for alpha-synuclein in the regulation of dopamine biosynthesis

31 March 2020

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Residual substantia nigra neuromelanin in Parkinson's disease is cross-linked to alpha-synuclein

31 March 2020

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Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

31 March 2020

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Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

31 March 2020

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Lipid interaction of alpha-synuclein during the metal-catalyzed oxidation in the presence of Cu2+ and H2O2.

31 March 2020

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Certain Metals Trigger Fibrillation of Methionine-oxidized α-Synuclein

31 March 2020

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Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

31 March 2020

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

31 March 2020

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Misfolded CuZnSOD and amyotrophic lateral sclerosis

31 March 2020

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Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

31 March 2020

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Mutant Superoxide Dismutase-1-Linked Familial Amyotrophic Lateral Sclerosis: Molecular Mechanisms of Neuronal Death and Protection

31 March 2020

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The Copper Chelator d‐Penicillamine Delays Onset of Disease and Extends Survival in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

31 March 2020

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Prevention of mutant SOD1 motoneuron degeneration by copper chelatorsin vitro

31 March 2020

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Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

31 March 2020

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Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading

31 March 2020

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Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis

31 March 2020

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Copper(2+) binding to the surface residue cysteine 111 of His46Arg human copper-zinc superoxide dismutase, a familial amyotrophic lateral sclerosis mutant

31 March 2020

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Is ALS caused by an altered oxidative activity of mutant superoxide dismutase?

31 March 2020

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Antioxidants as treatment for neurodegenerative disorders

31 March 2020

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Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease

31 March 2020

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A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study

31 March 2020

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Vitamin E and Alzheimer disease: the basis for additional clinical trials

31 March 2020

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Memantine in moderate-to-severe Alzheimer's disease

31 March 2020

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Memantine: update on the current evidence

31 March 2020

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Treating the full spectrum of dementia with memantine

31 March 2020

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Treatment of Parkinson's disease

31 March 2020

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A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group

31 March 2020

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Non-cholinergic strategies for treating and preventing Alzheimer's disease

31 March 2020

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Will caloric restriction and folate protect against AD and PD?

31 March 2020

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Intramuscular desferrioxamine in patients with Alzheimer's disease

31 March 2020

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

31 March 2020

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

31 March 2020

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Parkinson's disease: mechanisms and models

31 March 2020

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Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

31 March 2020

1 reference

Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion

31 March 2020

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Clinical, biochemical and molecular genetic correlations in Friedreich's ataxia

31 March 2020

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Effect of idebenone on cardiomyopathy in Friedreich's ataxia: a preliminary study

31 March 2020

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Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia

31 March 2020

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Idebenone treatment in Friedreich's ataxia: neurological, cardiac, and biochemical monitoring

31 March 2020

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The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis

31 March 2020

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Development of potential iron chelators for the treatment of Friedreich's ataxia: ligands that mobilize mitochondrial iron

31 March 2020

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The Copper Chaperone for Superoxide Dismutase

31 March 2020

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The role of copper in neurodegenerative disease

31 March 2020

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Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase

31 March 2020

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Mining copper transport genes

31 March 2020

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Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

31 March 2020

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Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

31 March 2020

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In vivo reduction of amyloid-beta by a mutant copper transporter

31 March 2020

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Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

31 March 2020

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An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

31 March 2020

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Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

31 March 2020

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Investigation into the correlation between the structure of hydroxypyridinones and blood-brain barrier permeability

31 March 2020

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Predicting blood-brain barrier partitioning of organic molecules using membrane-interaction QSAR analysis

31 March 2020

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Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1330

1 reference

6 December 2017

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