(Q36762412)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26096930%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

Resistance to HSP90 inhibition involving loss of MCL1 addiction (English)

1 reference

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17 February 2020

2

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17 February 2020

Kyle B Matchett

9

1 reference

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17 February 2020

author name string

S Busacca

1

1 reference

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17 February 2020

I R Powley

3

1 reference

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17 February 2020

D A Proia

4

1 reference

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17 February 2020

M Sequeira

5

1 reference

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17 February 2020

J Le Quesne

6

1 reference

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17 February 2020

A Klabatsa

7

1 reference

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17 February 2020

J M Edwards

8

1 reference

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17 February 2020

J L Luo

10

1 reference

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17 February 2020

J H Pringle

11

1 reference

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17 February 2020

M El-Tanani

12

1 reference

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17 February 2020

M MacFarlane

13

1 reference

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17 February 2020

D A Fennell

14

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17 February 2020

language of work or name

English

0 references

publication date

22 June 2015

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17 February 2020

1 reference

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17 February 2020

volume

35

1 reference

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17 February 2020

issue

12

1 reference

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17 February 2020

page(s)

1483-1492

1 reference

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Creative Commons Attribution 4.0 International

17 February 2020

copyright license

start time

22 June 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin

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UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib

29 September 2017

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FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism

29 September 2017

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E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells

29 September 2017

1 reference

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Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain

29 September 2017

1 reference

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Heat shock protein 90 inhibitors in non-small-cell lung cancer

29 September 2017

1 reference

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Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology

29 September 2017

1 reference

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Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer.

29 September 2017

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Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.

29 September 2017

1 reference

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Systematic identification of genomic markers of drug sensitivity in cancer cells

29 September 2017

1 reference

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The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

HSP90 inhibition: two-pronged exploitation of cancer dependencies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

BRCA1 is an essential mediator of vinorelbine-induced apoptosis in mesothelioma.

29 September 2017

1 reference

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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

29 September 2017

1 reference

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TRAP-1, the mitochondrial Hsp90.

29 September 2017

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Hallmarks of Cancer: The Next Generation

29 September 2017

1 reference

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Targeting the dynamic HSP90 complex in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

The landscape of somatic copy-number alteration across human cancers

29 September 2017

1 reference

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Structural basis of the radicicol resistance displayed by a fungal hsp90

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Mcl-1 is a potential therapeutic target in multiple types of cancer

29 September 2017

1 reference

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mTORC1 promotes survival through translational control of Mcl-1.

29 September 2017

1 reference

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Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

29 September 2017

1 reference

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BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death.

29 September 2017

1 reference

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Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

A stapled BID BH3 helix directly binds and activates BAX

29 September 2017

1 reference

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Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

29 September 2017

1 reference

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

29 September 2017

1 reference

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The pathophysiology of mitochondrial cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Cell death: critical control points

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

PROMO: detection of known transcription regulatory elements using species-tailored searches

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

PUMA, a novel proapoptotic gene, is induced by p53

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Hsp90 as a capacitor for morphological evolution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

5 September 2018

Drugging cancer genomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Functional analysis of the human MCL-1 gene

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819782

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

5 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2015.213

PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2015.213

A TRAIL-R1-specific ligand in combination with doxorubicin selectively targets primary breast tumour cells for apoptosis

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2015.213

31 March 2020

Identifiers

DOI

10.1038/ONC.2015.213

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26096930%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26096930%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PubMed publication ID

26096930

1 reference