(Q36763663)

16 August 2017

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title

Toll or toll-free adjuvant path toward the optimal vaccine development (English)

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16 August 2017

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1

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16 August 2017

2

Shizuo Akira

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16 August 2017

language of work or name

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17 March 2007

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Journal of Clinical Immunology

16 August 2017

published in

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16 August 2017

volume

27

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16 August 2017

issue

4

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16 August 2017

page(s)

363-371

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https://scigraph.springernature.com/pub.10.1007/s10875-007-9087-x

16 August 2017

exact match

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cites work

TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses

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Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

21 January 2018

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TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells

21 January 2018

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The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells.

21 January 2018

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Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity

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21 January 2018

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Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

21 January 2018

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CpG RNA: identification of novel single-stranded RNA that stimulates human CD14+CD11c+ monocytes

21 January 2018

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Cutting edge: innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high-level IL-12 secretion by dendritic cells

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Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.

21 January 2018

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Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice

21 January 2018

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Genomic DNA released by dying cells induces the maturation of APCs

21 January 2018

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Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway

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12 December 2020

Innate immune recognition of nucleic acids: beyond toll-like receptors

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12 December 2020

Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides

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12 December 2020

Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling

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12 December 2020

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

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12 December 2020

Tripalmitoyl-S-glyceryl-cysteine-dependent OspA vaccination of toll-like receptor 2-deficient mice results in effective protection from Borrelia burgdorferi challenge

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12 December 2020

DNA vaccines: immunology, application, and optimization*

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12 December 2020

A Toll-like receptor recognizes bacterial DNA

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12 December 2020

TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine.

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12 December 2020

Innate immune recognition

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12 December 2020

Nod-like proteins in immunity, inflammation and disease

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12 December 2020

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

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12 December 2020

The use of oil adjuvants in therapeutic vaccines

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12 December 2020

Sensing of bacteria: NOD a lonely job

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12 December 2020

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

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12 December 2020

Innate immune recognition of viral infection

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12 December 2020

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

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12 December 2020

Control of B-cell responses by Toll-like receptors

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12 December 2020

Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation

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12 December 2020

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

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12 December 2020

Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection

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12 December 2020

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

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12 December 2020

TLR ignores methylated RNA?

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12 December 2020

Therapeutic potential of Toll-like receptor 9 activation

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12 December 2020

TLR9 pathway is involved in adjuvant effects of plasmid DNA-based vaccines

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12 December 2020

Gout-associated uric acid crystals activate the NALP3 inflammasome

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12 December 2020

Toll-dependent control mechanisms of CD4 T cell activation.

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12 December 2020

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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12 December 2020

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

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12 December 2020

TLR9 in health and disease

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12 December 2020

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

1 reference

12 December 2020

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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12 December 2020

Discrimination of bacterial lipoproteins by Toll-like receptor 6

1 reference

12 December 2020

Immunobiological activities of nontoxic lipid A: enhancement of nonspecific resistance in combination with trehalose dimycolate against viral infection and adjuvant effects.

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12 December 2020

5'-Triphosphate RNA is the ligand for RIG-I

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12 December 2020

Immunological responses after immunisation of mice with microparticles containing antigen and single stranded RNA (polyuridylic acid).

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12 December 2020

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

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12 December 2020

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

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12 December 2020

Intranasal vaccination with recombinant outer membrane protein CD and adamantylamide dipeptide as the mucosal adjuvant enhances pulmonary clearance of Moraxella catarrhalis in an experimental murine model

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12 December 2020

Pathogen recognition and innate immunity

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12 December 2020

Innate immune recognition of, and regulation by, DNA.

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12 December 2020

The Mycoplasma-derived lipopeptide MALP-2 is a potent mucosal adjuvant

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12 December 2020

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

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12 December 2020

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

1 reference

12 December 2020

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

1 reference

12 December 2020

Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis

1 reference

12 December 2020

NOD-LRR proteins: role in host-microbial interactions and inflammatory disease

1 reference

12 December 2020

Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides

1 reference

12 December 2020

Targeting the innate immune response with improved vaccine adjuvants

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12 December 2020

A phase I-II trial of multiple-dose polyriboinosic-polyribocytidylic acid in patieonts with leukemia or solid tumors

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12 December 2020

On regulation of phagosome maturation and antigen presentation

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12 December 2020

Adjuvant activity in delayed hypersensitivity of the peptidic part of bacterial peptidoglycans

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12 December 2020

HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates

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12 December 2020

The role of toll-like receptors in the pathogenesis and treatment of dermatological disease

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12 December 2020

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

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12 December 2020

Synthetic toll-like receptor 4 agonists stimulate innate resistance to infectious challenge.

1 reference

12 December 2020

Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes

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12 December 2020

Gene expression in actinic keratoses: pharmacological modulation by imiquimod.

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12 December 2020

Cryopyrin activates the inflammasome in response to toxins and ATP

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12 December 2020

Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection

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12 December 2020

Toll-like receptors as adjuvant receptors

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12 December 2020

Enhancement of TLR-mediated innate immune responses by peptidoglycans through NOD signaling

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12 December 2020

Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88.

1 reference

12 December 2020

Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells

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12 December 2020

Immunostimulatory sequences of DNA and conjugates in the treatment of allergic rhinitis

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12 December 2020

Manifold mechanisms of Toll-like receptor-ligand recognition

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12 December 2020

Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.

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12 December 2020

Immunotherapeutic uses of CpG oligodeoxynucleotides

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12 December 2020

Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529.

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12 December 2020

Purified malaria pigment (hemozoin) enhances dendritic cell maturation and modulates the isotype of antibodies induced by a DNA vaccine

1 reference

12 December 2020

Triggering TLR signaling in vaccination

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12 December 2020

Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates

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12 December 2020

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

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12 December 2020

Recent advances in the discovery and delivery of vaccine adjuvants

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12 December 2020

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

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12 December 2020

Synthetic lipopeptide adjuvants and Toll-like receptor 2--structure-activity relationships

1 reference

12 December 2020

From the analyst's couch: TLR-targeted therapeutics

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12 December 2020

TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity

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12 December 2020

The use of Toll-like receptor-7 agonist in the treatment of basal cell carcinoma: an overview

1 reference

12 December 2020

Aluminum compounds as vaccine adjuvants

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12 December 2020

Toll-like receptor 3 promotes cross-priming to virus-infected cells.

1 reference

12 December 2020

Intracellular pattern recognition receptors in the host response

1 reference

12 December 2020

Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives

1 reference

12 December 2020

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

1 reference

12 December 2020

The immunobiology of the TLR9 subfamily

1 reference

12 December 2020

Dendritic cell (DC) based therapy for cervical cancer: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]:poly [C(12)U] (Ampligen R).

1 reference

12 December 2020

Cell type-specific involvement of RIG-I in antiviral response

1 reference

12 December 2020

Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity

1 reference

12 December 2020

10.1007/S10875-007-9087-X

Identifiers

DOI

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16 August 2017

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