(Q36776754)

English

Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1.

scientific article published on 11 March 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1. (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

1 reference

ChEBI release 2020-05-28

reactive oxygen species

1 reference

based on heuristic

inferred from title

author name string

Cynthia Lopez-Haber

1

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Marcelo G Kazanietz

2

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

publication date

11 March 2013

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Molecular Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

83

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

5

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

1141-1154

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3629833/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells.

1 reference

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Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion

1 reference

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Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells.

1 reference

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1 reference

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29 September 2017

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

1 reference

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29 September 2017

Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics

1 reference

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29 September 2017

Cell signaling by receptor tyrosine kinases

1 reference

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1 reference

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1 reference

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29 September 2017

Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif

1 reference

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29 September 2017

Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells

1 reference

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1 reference

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1 reference

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Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells

1 reference

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Epidermal growth factor activates Na(+/)H(+) exchanger in podocytes through a mechanism that involves Janus kinase and calmodulin

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Functional selectivity of EGF family peptide growth factors: implications for cancer

1 reference

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Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas.

1 reference

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Actin-aggregating cucurbitacins from Physocarpus capitatus

1 reference

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1 reference

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29 September 2017

Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo

1 reference

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Neuregulins and cancer.

1 reference

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Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion.

1 reference

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p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.

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1 reference

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Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase

1 reference

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1 reference

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29 September 2017

Redox-dependent downregulation of Rho by Rac.

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1 reference

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1 reference

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NFkappaB-independent signaling to the cyclin D1 gene by Rac.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3629833

5 September 2018

Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3629833

5 September 2018

Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation.

1 reference

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Rho GEFs and cancer: linking gene expression and metastatic dissemination

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https://pubmed.ncbi.nlm.nih.gov/23478800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox regulation of RhoA

1 reference

https://pubmed.ncbi.nlm.nih.gov/23478800

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/MOL.112.084293

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

ResearchGate publication ID

0 references

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