(Q37984123)

26 August 2017

title

Targeting Rho GTPase signaling for cancer therapy (English)

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26 August 2017

Michael F Olson

2

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author name string

Katerina Mardilovich

series ordinal

1

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26 August 2017

Mark Baugh

series ordinal

3

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26 August 2017

language of work or name

English

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publication date

1 February 2012

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26 August 2017

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26 August 2017

volume

8

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26 August 2017

issue

2

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26 August 2017

page(s)

165-177

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Rho GTPases in transformation and metastasis.

26 August 2017

cites work

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Dynamics of the Rho-family small GTPases in actin regulation and motility

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Targeting Ras and Rho GTPases as opportunities for cancer therapeutics

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The role of Rho GTPases in disease development

21 January 2018

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LIM kinases: function, regulation and association with human disease

21 January 2018

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Applications for ROCK kinase inhibition

21 January 2018

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21 January 2018

RHO-GTPases and cancer

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Cdc42 in oncogenic transformation, invasion, and tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.2217%2FFON.11.143

The diverse roles of Rac signaling in tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.2217%2FFON.11.143

Rho GTPases and the regulation of endothelial permeability

21 January 2018

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https://api.crossref.org/works/10.2217%2FFON.11.143

Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro

21 January 2018

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https://api.crossref.org/works/10.2217%2FFON.11.143

Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro

21 January 2018

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https://api.crossref.org/works/10.2217%2FFON.11.143

RhoA silencing reverts the resistance to doxorubicin in human colon cancer cells

21 January 2018

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https://api.crossref.org/works/10.2217%2FFON.11.143

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

21 January 2018

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https://api.crossref.org/works/10.2217%2FFON.11.143

An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells

21 January 2018

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https://api.crossref.org/works/10.2217%2FFON.11.143

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

21 January 2018

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https://api.crossref.org/works/10.2217%2FFON.11.143

Guanine nucleotide exchange factors for RhoGTPases: good therapeutic targets for cancer therapy?

21 January 2018

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https://api.crossref.org/works/10.2217%2FFON.11.143

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

An alternative transcript derived from the trio locus encodes a guanosine nucleotide exchange factor with mouse cell-transforming potential

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway

21 January 2018

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https://api.crossref.org/works/10.2217%2FFON.11.143

Peptide aptamers as guides for small-molecule drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Identification of TRIO-GEFD1 chemical inhibitors using the yeast exchange assay

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Blockade of Rac1 activity induces G1 cell cycle arrest or apoptosis in breast cancer cells through downregulation of cyclin D1, survivin, and X-linked inhibitor of apoptosis protein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Overexpression of Rac1 in leukemia patients and its role in leukemia cell migration and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Bacterial protein toxins that modify host regulatory GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Inhibition of RhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric toxin DC3B

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Characterization of new cell permeable C3-like proteins that inactivate Rho and stimulate neurite outgrowth on inhibitory substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Purification of TAT-C3 exoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Design and synthesis of small molecule RhoA inhibitors: a new promising therapy for cardiovascular diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Mechanisms of statin-mediated inhibition of small G-protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Phase I pharmacokinetic and pharmacodynamic study of the prenyl transferase inhibitor AZD3409 in patients with advanced cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Activating ROCK1 somatic mutations in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

The COOH terminus of Rho-kinase negatively regulates rho-kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Direct Rho-associated kinase inhibition [correction of inhibiton] induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Involvement of Rho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Tetrahydroisoquinoline Derivatives As Highly Selective and Potent Rho Kinase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Rho kinase (ROCK) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Structure-activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Chelerythrine is a potent and specific inhibitor of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Identification of chelerythrine as an inhibitor of BclXL function

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Pak4 induces premature senescence via a pathway requiring p16INK4/p19ARF and mitogen-activated protein kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Scaffolding function of PAK in the PDK1-Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Aptamer-derived peptides as potent inhibitors of the oncogenic RhoGEF Tgat

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Dying Alone: A Tale of Rho

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

The Rho-Regulated ROCK Kinases in Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.11.143

21 January 2018

Identifiers

DOI

10.2217/FON.11.143

1 reference

26 August 2017

1 reference