(Q40375910)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16150730%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

title

RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo (English)

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6 January 2020

8

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6 January 2020

author name string

Laurent Désiré

1

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6 January 2020

Jérôme Bourdin

2

1 reference

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6 January 2020

Nadia Loiseau

3

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6 January 2020

Hélène Peillon

4

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6 January 2020

Virginie Picard

5

1 reference

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6 January 2020

Catherine De Oliveira

6

1 reference

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6 January 2020

Florence Bachelot

7

1 reference

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6 January 2020

Thierry Taverne

9

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6 January 2020

Eric Beausoleil

10

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6 January 2020

Sandrine Lacombe

11

1 reference

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6 January 2020

Dominique Drouin

12

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6 January 2020

Fabien Schweighoffer

13

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6 January 2020

language of work or name

English

0 references

publication date

8 September 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16150730%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

6 January 2020

number of pages

10

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

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6 January 2020

volume

280

1 reference

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6 January 2020

issue

45

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6 January 2020

page(s)

37516-37525

1 reference

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Alzheimer's disease: the amyloid cascade hypothesis

6 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

BACE1: the beta-secretase enzyme in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

A fluid connection: cholesterol and Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

A detergent-insoluble membrane compartment contains A beta in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Rho GTPases and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Biochemical and morphological analysis on the localization of Rac1 in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Fe65 is not involved in the platelet-derived growth factor-induced processing of Alzheimer's amyloid precursor protein, which activates its caspase-directed cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Guinea pigs as a nontransgenic model for APP processing in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Learning and memory deficits in Notch mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

Increased long-term potentiation in the CA1 region of rat hippocampus via modulation of GTPase signalling or inhibition of Rho kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507913200

21 January 2018

Identifiers

DOI

10.1074/JBC.M507913200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16150730%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference