(Q35098538)

6 August 2017

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title

Guinea pigs as a nontransgenic model for APP processing in vitro and in vivo (English)

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6 August 2017

Mike Beck

1

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6 August 2017

Volker Bigl

series ordinal

2

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6 August 2017

Steffen Rossner

series ordinal

3

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6 August 2017

language of work or name

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1 April 2003

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6 August 2017

Neurochemical Research

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6 August 2017

28

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6 August 2017

3-4

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6 August 2017

637-644

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https://scigraph.springernature.com/pub.10.1023/a:1022850113083

6 August 2017

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cites work

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12 December 2020

The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.

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12 December 2020

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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12 December 2020

Beta-amyloid peptides as direct cholinergic neuromodulators: a missing link?

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12 December 2020

Protein kinase Calpha and beta1 isoforms are regulators of alpha-secretory proteolytic processing of amyloid precursor protein in vivo

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12 December 2020

Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein

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12 December 2020

Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

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12 December 2020

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

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12 December 2020

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

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12 December 2020

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

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12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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12 December 2020

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

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12 December 2020

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

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12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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12 December 2020

Disturbances of the blood-brain barrier without expression of amyloid precursor protein- containing neuritic clusters or neuronal loss during late stages of thiamine deficiency in guinea pigs

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12 December 2020

Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence

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12 December 2020

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

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12 December 2020

Human and rodent Alzheimer beta-amyloid peptides acquire distinct conformations in membrane-mimicking solvents.

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12 December 2020

The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling

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12 December 2020

Beta-amyloid precursor protein cleavage by a membrane-bound protease

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12 December 2020

The Role of presenilins in gamma-secretase activity

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12 December 2020

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

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12 December 2020

Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain.

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12 December 2020

Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity

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12 December 2020

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

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12 December 2020

Detection and quantitation of cellularly derived amyloid beta peptides by immunoprecipitation-HPLC-MS.

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12 December 2020

Modulation of amyloid precursor protein processing by compounds with various mechanisms of action: detection by liquid phase electrochemiluminescent system

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12 December 2020

Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence.

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12 December 2020

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

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12 December 2020

Correlation between scores for dementia and counts of 'senile plaques' in cerebral grey matter of elderly subjects.

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12 December 2020

Guinea-pig primary cell cultures provide a model to study expression and amyloidogenic processing of endogenous amyloid precursor protein

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12 December 2020

Protein kinase C activation increases release of secreted amyloid precursor protein without decreasing Abeta production in human primary neuron cultures.

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12 December 2020

Metabotropic glutamate receptor activation in vivo induces intraneuronal amyloid immunoreactivity in guinea pig hippocampus

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12 December 2020

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12 December 2020

Amyloid beta-protein (Abeta) 1-40 but not Abeta1-42 contributes to the experimental formation of Alzheimer disease amyloid fibrils in rat brain.

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12 December 2020

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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12 December 2020

Nontoxic amyloid beta peptide 1-42 suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer's disease.

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12 December 2020

Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine

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12 December 2020

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

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12 December 2020

Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.

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12 December 2020

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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12 December 2020

Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein.

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12 December 2020

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

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12 December 2020

Modulation of APP processing and secretion by okadaic acid in primary guinea pig neurons

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12 December 2020

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

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12 December 2020

Factors influencing the processing and function of the amyloid beta precursor protein--a potential therapeutic target in Alzheimer's disease?

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12 December 2020

Amyloidogenicity of rodent and human beta A4 sequences.

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12 December 2020

Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease.

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12 December 2020

Ovariectomy and 17beta-estradiol modulate the levels of Alzheimer's amyloid beta peptides in brain

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12 December 2020

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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12 December 2020

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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12 December 2020

The mean A beta load in the hippocampus correlates with duration and severity of dementia in subgroups of Alzheimer disease.

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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12 December 2020

Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis

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12 December 2020

Amyloid precursor protein in guinea pigs--complete cDNA sequence and alternative splicing.

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12 December 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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12 December 2020

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

1 reference

12 December 2020

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1 reference

12 December 2020

Constitutive overactivation of protein kinase C in guinea pig brain increases alpha-secretory APP processing without decreasing beta-amyloid generation

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12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

Mass spectrometry of purified amyloid beta protein in Alzheimer's disease

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12 December 2020

Reduction of cortical amyloid beta levels in guinea pig brain after systemic administration of physostigmine.

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12 December 2020

Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein

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12 December 2020

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

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12 December 2020

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

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12 December 2020

Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques

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12 December 2020

Amyloid precursor protein secretion and beta A4 amyloid generation are not mutually exclusive

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12 December 2020

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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12 December 2020

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

12 December 2020

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

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12 December 2020

The human serotonin 5-HT4 receptor regulates secretion of non-amyloidogenic precursor protein.

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12 December 2020

Identifiers

DOI

10.1023/A:1022850113083

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Dimensions Publication ID

6 August 2017

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