(Q44367827)

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Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway.

scientific article published in March 2003

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scholarly article

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Europe PubMed Central

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1 November 2019

Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway (English)

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1 November 2019

Nicola Zambrano

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1 November 2019

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1 November 2019

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Davide Gianni

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1 November 2019

Marida Bimonte

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1 November 2019

Giuseppina Minopoli

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1 November 2019

Luc Mercken

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1 November 2019

Fabio Talamo

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1 November 2019

Tommaso Russo

8

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1 November 2019

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1 March 2003

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1 November 2019

Journal of Biological Chemistry

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1 November 2019

278

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1 November 2019

11

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1 November 2019

9290-9297

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1 November 2019

The beta-secretase, BACE: a prime drug target for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

A cell biological perspective on Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

A detergent-insoluble membrane compartment contains A beta in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Transcription activation by the adenovirus E1a protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Bovine cytosolic 5'-nucleotidase acts through the formation of an aspartate 52-phosphoenzyme intermediate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

ProFound: an expert system for protein identification using mass spectrometric peptide mapping information

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Neuronotrophic factors released by C6 glioma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Association between the PDGF receptor and members of the src family of tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

An intramolecular SH3-domain interaction regulates c-Abl activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Regulation of c-myc expression by PDGF through Rho GTPases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Regulation of amyloid precursor protein cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Platelet-derived growth factor promotes survival of rat and human mesencephalic dopaminergic neurons in culture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

PDGF-BB exerts trophic activity on cultured GABA interneurons from the newborn rat cerebellum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

c-src gene product in developing rat brain is enriched in nerve growth cone membranes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Transmission of growth cone traction force through apCAM-cytoskeletal linkages is regulated by Src family tyrosine kinase activity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

The role of Rho GTPases and associated kinases in regulating neurite outgrowth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Rac GTPases control axon growth, guidance and branching

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Emerging from the Pak: the p21-activated protein kinase family.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Activation and translocation of c-Src to the cytoskeleton by both platelet-derived growth factor and epidermal growth factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

NMDA channel regulation by channel-associated protein tyrosine kinase Src.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

A RIP tide in neuronal signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211899200

21 January 2018

Identifiers

10.1074/JBC.M211899200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12645527%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12645527%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

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