(Q24318340)

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Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation

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scholarly article

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Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation (English)

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G protein-coupled receptor

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phosphorylation

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SRC proto-oncogene, non-receptor tyrosine kinase

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GOA release 2020-03-11

signal transduction

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GOA release 2020-03-11

Robert Lefkowitz

5

object named as

R J Lefkowitz

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author name string

L M Luttrell

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G J Della Rocca

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T van Biesen

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D K Luttrell

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language of work or name

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publication date

14 February 1997

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Journal of Biological Chemistry

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272

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7

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4637-44

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Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II

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Angiotensin II stimulates the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells

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Involvement of MAP kinase activators in angiotensin II-induced activation of MAP kinases in cultured vascular smooth muscle cells

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Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

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Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

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Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

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A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits

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Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

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The neu oncogene encodes an epidermal growth factor receptor-related protein

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Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1 reference

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Proteins regulating Ras and its relatives

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Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

1 reference

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Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway

1 reference

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Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

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Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors

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A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

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pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions

1 reference

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Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction

1 reference

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Involvement of pp60c-src with two major signaling pathways in human breast cancer

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Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits

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G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein

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Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells

1 reference

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Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha

1 reference

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Electroporation of pp60c−srcAntibodies Inhibits the Angiotensin II Activation of Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells

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Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation

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G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase.Shc adapter protein signaling complexes

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Thrombin Stimulates Phosphorylation of Insulin-like Growth Factor-1 Receptor, Insulin Receptor Substrate-1, and Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells

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Angiotensin II Controls p21 Activity via pp60

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c-Cbl is transiently tyrosine-phosphorylated, ubiquitinated, and membrane-targeted following CSF-1 stimulation of macrophages

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Nuclear signaling by endothelin-1 requires Src protein-tyrosine kinases

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Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway

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Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases

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Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes

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Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

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Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase

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A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicity

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Angiotensin II Activates pp60 c- src in Vascular Smooth Muscle Cells

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Immunodetection of the Ligand-Activated Receptor for Epidermal Growth Factor

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