(Q42733267)

English

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

scientific article published on 28 March 2011

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27 January 2020

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG) (English)

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27 January 2020

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27 January 2020

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27 January 2020

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Radovan Dvorsky

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27 January 2020

Lars Christian Haeusler

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27 January 2020

Ion C Cirstea

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27 January 2020

Katharina Uhlenbrock

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27 January 2020

Mohammad Reza Ahmadian

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28 March 2011

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27 January 2020

Journal of Biological Chemistry

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27 January 2020

18202-18212

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27 January 2020

Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF

1 reference

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27 May 2018

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

1 reference

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27 May 2018

Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF.

1 reference

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27 May 2018

Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors

1 reference

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27 May 2018

The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA.

1 reference

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27 May 2018

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.

1 reference

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27 May 2018

On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.

1 reference

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27 May 2018

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs

1 reference

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27 May 2018

Regulation of Rho guanine nucleotide exchange factors by G proteins

1 reference

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Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression

1 reference

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27 May 2018

The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation

1 reference

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27 May 2018

Pleckstrin homology (PH) domains and phosphoinositides

1 reference

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27 May 2018

Structural evidence for a common intermediate in small G protein-GEF reactions

1 reference

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27 May 2018

Catching a GEF by its tail

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Coupling receptor tyrosine kinases to Rho GTPases--GEFs what's the link

1 reference

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27 May 2018

Fluorescence approaches for monitoring interactions of Rho GTPases with nucleotides, regulators, and effectors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Always look on the bright site of Rho: structural implications for a conserved intermolecular interface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle

1 reference

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27 May 2018

Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Molecular basis for Rho GTPase signaling specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Different regulation of the Trio Dbl-Homology domains by their associated PH domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Cell migration: Rho GTPases lead the way

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase

1 reference

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27 May 2018

Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11.

1 reference

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27 May 2018

Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Rho GTPases in cell biology

1 reference

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27 May 2018

Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

1 reference

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27 May 2018

Signaling to the Rho GTPases: networking with the DH domain

1 reference

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27 May 2018

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

1 reference

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27 May 2018

Dbl family guanine nucleotide exchange factors

1 reference

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27 May 2018

The guanine nucleotide-binding switch in three dimensions

1 reference

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27 May 2018

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors

1 reference

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27 May 2018

Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins

1 reference

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27 May 2018

Fluorescence methods for monitoring interactions of Rab proteins with nucleotides, Rab escort protein, and geranylgeranyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

1 reference

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27 May 2018

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules

1 reference

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27 May 2018

Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

27 May 2018

Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member

1 reference

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27 May 2018

Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins

1 reference

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27 May 2018

Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation

1 reference

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27 May 2018

The Ras mutant D119N is both dominant negative and activated

1 reference

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27 May 2018

The DH protein family, exchange factors for Rho-like GTPases

1 reference

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27 May 2018

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

1 reference

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27 May 2018

NTF2 mediates nuclear import of Ran.

1 reference

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27 May 2018

NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio

1 reference

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27 May 2018

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

1 reference

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27 May 2018

p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

1 reference

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27 May 2018

Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue

1 reference

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27 May 2018

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

1 reference

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27 May 2018

Crystal structure of RhoA-GDP and its functional implications

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27 May 2018

Dbl family proteins

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27 May 2018

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

1 reference

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27 May 2018

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product

1 reference

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27 May 2018

A role for Rac in Tiam1-induced membrane ruffling and invasion

1 reference

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27 May 2018

Reassessment of Ellman's reagent

1 reference

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27 May 2018

Internal dynamics control activation and activity of the autoinhibited Vav DH domain

1 reference

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16 August 2018

Purification and biochemical properties of Rac1, 2, 3 and the splice variant Rac1b

1 reference

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16 August 2018

Comparative functional analysis of the Rac GTPases

1 reference

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16 August 2018

Dissociation of GDP dissociation inhibitor and membrane translocation are required for efficient activation of Rac by the Dbl homology-pleckstrin homology region of Tiam.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093892

16 August 2018

Fluorescently labelled guanine nucleotide binding proteins to analyse elementary steps of GAP-catalysed reactions

1 reference

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16 August 2018

Fluorescence methods in the study of small GTP-binding proteins

1 reference

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16 August 2018

Mechanisms for reversible regulation between G13 and Rho exchange factors

1 reference

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16 August 2018

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

1 reference

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16 August 2018

Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif

1 reference

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21 January 2018

The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor

1 reference

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12 December 2020

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The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF

1 reference

https://pubmed.ncbi.nlm.nih.gov/21454492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asef is a Cdc42-specific guanine nucleotide exchange factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21454492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sec2 is a Highly Efficient Exchange Factor for the Rab Protein Sec4

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https://pubmed.ncbi.nlm.nih.gov/21454492

12 December 2020

based on heuristic

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The Kinetic Mechanism of Ran-Nucleotide Exchange Catalyzed by RCC1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21454492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm

1 reference

https://pubmed.ncbi.nlm.nih.gov/21454492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorescence assays of Cdc42 interactions with target/effector proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21454492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.226431

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21454492%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21454492%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21454492%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

ResearchGate publication ID

0 references

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