(Q36797981)

16 August 2017

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title

The 6-hydroxydopamine model of Parkinson's disease (English)

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16 August 2017

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1

Nicola Simola

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16 August 2017

Micaela Morelli

2

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author name string

Anna R Carta

series ordinal

3

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16 August 2017

publication date

1 April 2007

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16 August 2017

published in

Neurotoxicity Research

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16 August 2017

volume

11

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16 August 2017

issue

3-4

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16 August 2017

page(s)

151-167

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Developmental characteristics of brain catecholamines and tyrosine hydroxylase in the rat: effects of 6-hydroxydopamine

16 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FBF03033565

Spatial memory impairment induced by lesion of the mesohippocampal dopaminergic system in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033565

Morphological changes in the rat neostriatum after unilateral 6-hydroxydopamine injections into the nigrostriatal pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033565

Effects on renal sympathetic axons in dog of acute 6-hydroxydopamine treatment in combination with selective neuronal uptake inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033565

Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test

21 January 2018

1 reference

12 December 2020

Dopamine D1 receptor-dependent trafficking of striatal NMDA glutamate receptors to the postsynaptic membrane.

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12 December 2020

Applications of the Morris water maze in the study of learning and memory

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12 December 2020

Behavioral differences between neonatal and adult 6-hydroxydopamine-treated rats to dopamine agonists: relevance to neurological symptoms in clinical syndromes with reduced brain dopamine

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12 December 2020

Ventrolateral striatal dopamine depletions impair feeding and food handling in rats

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12 December 2020

Behavioural sensitization in 6-hydroxydopamine-lesioned rats is related to compositional changes of the AP-1 transcription factor: evidence for induction of FosB- and JunD-related proteins.

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12 December 2020

Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvement

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12 December 2020

Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines

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12 December 2020

Selective lesion of central dopamine or noradrenaline neuron systems in the neonatal rat: motor behavior and monoamine alterations at adult stage

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12 December 2020

Testing forelimb placing "across the midline" reveals distinct, lesion-dependent patterns of recovery in rats

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12 December 2020

Differential expression and ser897 phosphorylation of striatal N-methyl-d-aspartate receptor subunit NR1 in animal models of Parkinson's disease.

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12 December 2020

Alterations in subunit expression, composition, and phosphorylation of striatal N-methyl-D-aspartate glutamate receptors in a rat 6-hydroxydopamine model of Parkinson's disease.

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12 December 2020

Time-course of nigrostriatal damage, basal ganglia metabolic changes and behavioural alterations following intrastriatal injection of 6-hydroxydopamine in the rat: new clues from an old model

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12 December 2020

Effects of haloperidol and SCH 23390 on acoustic startle in animals depleted of dopamine as neonates: implications for neuropsychiatric syndromes

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12 December 2020

Skilled motor deficits in rats induced by ventrolateral striatal dopamine depletions: behavioral and pharmacological characterization

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12 December 2020

Dopamine transporter function assessed by antisense knockdown in the rat: protection from dopamine neurotoxicity

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12 December 2020

Evaluation of simple and complex sensorimotor behaviours in rats with a partial lesion of the dopaminergic nigrostriatal system

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12 December 2020

Tremulous jaw movements in rats: a model of parkinsonian tremor.

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12 December 2020

Decreased striatal D1 binding density following mesotelencephalic 6-hydroxydopamine injections: an autoradiographic analysis

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12 December 2020

Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking

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12 December 2020

A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal function

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12 December 2020

In vitro studies of ferritin iron release and neurotoxicity.

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12 December 2020

Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease.

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12 December 2020

Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease.

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12 December 2020

Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease

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12 December 2020

Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28.

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12 December 2020

Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice

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12 December 2020

Time-dependent changes in striatal glutamate synapses following a 6-hydroxydopamine lesion.

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12 December 2020

Early cognitive changes and nondementing behavioral abnormalities in Parkinson's disease.

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12 December 2020

D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2/MAP kinase.

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12 December 2020

Unlike MPP+, apoptosis induced by 6-OHDA in PC12 cells is independent of mitochondrial inhibition

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12 December 2020

Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway

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12 December 2020

Dopamine, 6-hydroxydopamine, iron, and dioxygen--their mutual interactions and possible implication in the development of Parkinson's disease

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12 December 2020

Stereospecific blockade of N-methyl-D-aspartate transmission by MK 801 prevents priming of SKF 38393-induced turning

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12 December 2020

Agonist-induced homologous and heterologous sensitization to D-1- and D-2-dependent contraversive turning

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12 December 2020

Modulation of 6-hydroxydopamine oxidation by various proteins

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12 December 2020

6-Hydroxydopamine toxicity towards human SH-SY5Y dopaminergic neuroblastoma cells: independent of mitochondrial energy metabolism

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12 December 2020

Chemical neurotoxins as denervation tools in neurobiology

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12 December 2020

Electrophysiology of dopamine-denervated striatal neurons. Implications for Parkinson's disease

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12 December 2020

Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study

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12 December 2020

The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles

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12 December 2020

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

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12 December 2020

Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease

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12 December 2020

Manganese catalyzed auto-oxidation of dopamine to 6-hydroxydopamine in vitro

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12 December 2020

Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models.

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12 December 2020

cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum

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12 December 2020

Effect of dopamine denervation and dopamine agonist administration on serine phosphorylation of striatal NMDA receptor subunits

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12 December 2020

Decrease in adrenaline content of various organs of the rat after 6-hydroxydopamine

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12 December 2020

Quantification of lesion-induced dopaminergic supersensitivity using the rotational model in the mouse

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12 December 2020

Destruction of sympathetic nerve terminals by 6-hydroxydopamine: protection by 1-phenyl-3-(2-thiazolyl)-2-thiourea, diethyldithiocarbamate, methimazole, cysteamine, ethanol and n-butanol

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12 December 2020

Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum

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12 December 2020

Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats

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12 December 2020

Generation of the Neurotoxin 6-Hydroxydopamine by Peroxidase/H2O2 Oxidation of Dopamine

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12 December 2020

Enhanced tyrosine phosphorylation of striatal NMDA receptor subunits: effect of dopaminergic denervation and L-DOPA administration

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12 December 2020

Monosynaptic input from the nucleus accumbens--ventral striatum region to retrogradely labelled nigrostriatal neurones.

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12 December 2020

cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase

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12 December 2020

"Priming" to dopamine agonist-induced contralateral turning as a model of non-associative sensitization to the expression of the post-synaptic dopamine message

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12 December 2020

Two distinct mechanisms are involved in 6-hydroxydopamine- and MPP+-induced dopaminergic neuronal cell death: role of caspases, ROS, and JNK

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12 December 2020

Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats

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12 December 2020

Changes in sleep-wakefulness after 6-hydroxydopamine lesion of the preoptic area

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12 December 2020

Neurochemical and behavioural changes in zebrafish Danio rerio after systemic administration of 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

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12 December 2020

Nature of inhibition of mitochondrial respiratory complex I by 6-Hydroxydopamine

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12 December 2020

Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: studies on medial forebrain bundle and striatal lesions

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12 December 2020

Tremulous characteristics of the vacuous jaw movements induced by pilocarpine and ventrolateral striatal dopamine depletions

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12 December 2020

Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons.

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12 December 2020

Behavioural effects of subthalamic nucleus lesions in the hemiparkinsonian marmoset (Callithrix jacchus).

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12 December 2020

Quantifying operant behavior deficits in rats with bilateral 6-hydroxydopamine lesions of the ventrolateral striatum

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12 December 2020

Nitrite- and Peroxide-Dependent Oxidation Pathways of Dopamine: 6-Nitrodopamine and 6-Hydroxydopamine Formation as Potential Contributory Mechanisms of Oxidative Stress- and Nitric Oxide-Induced Neurotoxicity in Neuronal Degeneration

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12 December 2020

Role of renal nerve activity, plasma catecholamines and plasma vasopressin in cardiovascular responses to intracisternal neurotoxins in the rabbit

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12 December 2020

Proposed animal model of severe Parkinson's disease: neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum.

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12 December 2020

Bilateral 6-hydroxydopamine lesion in the dopaminergic A8 cell group produces long-lasting deficits in motor programming of cats

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12 December 2020

Functional changes induced by neonatal cerebral 6-hydroxydopamine treatment: effects of dose levels on behavioral parameters

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12 December 2020

Analysis of limb use by control rats and unilateral DA-depleted rats in the Montoya staircase test: movements, impairments and compensatory strategies

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12 December 2020

Parkinson's syndrome induced in cats by the use of 6-hydroxydopamine. Observations of behavior and motor disorders

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12 December 2020

Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway.

1 reference

12 December 2020

L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA.

1 reference

12 December 2020

The effect of chemical and surgical sympathectomy on gastric secretion and innervation

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12 December 2020

Effect of sympathetic denervation on the relaxing responses of rabbit arterial smooth muscle

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12 December 2020

Partial loss of dopaminergic neurons in the substantia nigra, ventrotegmental area and the retrorubral area -- model of the early beginning of Parkinson's symptomatology?

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12 December 2020

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12 December 2020

Time and dose dependence of the 'priming' of the expression of dopamine receptor supersensitivity

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12 December 2020

D1 dopamine receptor supersensitivity in the dopamine-depleted striatum animal model of Parkinson's disease

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12 December 2020

Impaired problem solving in Parkinson's disease: impact of a set-shifting deficit

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12 December 2020

Cyclic AMP responsive element binding protein phosphorylation and persistent expression of levodopa-induced response alterations in unilateral nigrostriatal 6-OHDA lesioned rats.

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12 December 2020

Attenuation of 6-hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic mice

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12 December 2020

Dopamine receptor supersensitivity: an outcome and index of neurotoxicity

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12 December 2020

Regional effects of 6-hydroxydopamine (6-OHDA) on free radical scavengers in rat brain

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12 December 2020

Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic mice

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12 December 2020

Active and passive avoidance learning in rats neonatally treated with intraventricular 6-hydroxydopamine.

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12 December 2020

Modification of adenosine extracellular levels and adenosine A(2A) receptor mRNA by dopamine denervation.

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12 December 2020

The "staircase test": a measure of independent forelimb reaching and grasping abilities in rats

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12 December 2020

Proposed animal model of attention deficit hyperactivity disorder

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12 December 2020

Sensorimotor deficits in a unilateral intrastriatal 6-OHDA partial lesion model of Parkinson's disease in marmoset monkeys.

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12 December 2020

The determination of hydroxydopamines and other trace amines in the urine of parkinsonian patients and normal controls

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12 December 2020

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12 December 2020

Phosphorylation-dependent regulation of N-methyl-D-aspartate receptors by calmodulin

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12 December 2020

Effects of chemical sympathectomy with 6-hydroxydopamine on cardiac output and its distribution in the rat.

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12 December 2020

Priming of 6-hydroxydopamine-lesioned rats with L-DOPA or quinpirole results in an increase in dopamine D1 receptor-dependent cyclic AMP production in striatal tissue.

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12 December 2020

Early administration of entacapone prevents levodopa-induced motor fluctuations in hemiparkinsonian rats

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12 December 2020

Regulation of NMDA receptors by tyrosine kinases and phosphatases

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12 December 2020

Neglect of memory after dopaminergic lesions in monkeys

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12 December 2020

Reversal of parkinsonian symptoms in primates by antagonism of excitatory amino acid transmission: potential mechanisms of action

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12 December 2020

Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.

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12 December 2020

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12 December 2020

CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury

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12 December 2020

Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors.

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12 December 2020

Reductions in spontaneous locomotor activity in aged male, but not female, rats in a model of early Parkinson's disease

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12 December 2020

Behavioural expression of D-1 receptor supersensitivity depends on previous stimulation of D-2 receptors

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12 December 2020

Striatal dopamine- and glutamate-mediated dysregulation in experimental parkinsonism

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12 December 2020

Local cerebral glucose utilization after D1 receptor stimulation in 6-OHDA lesioned rats: effect of sensitization (priming) with a dopaminergic agonist

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12 December 2020

Rasagiline enhances L-DOPA-induced contralateral turning in the unilateral 6-hydroxydopamine-lesioned guinea-pig

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12 December 2020

Dysfunction of the cortico-basal ganglia-cortical loop in a rat model of early parkinsonism is reversed by metabotropic glutamate receptor 5 antagonism.

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12 December 2020

Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease

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12 December 2020

Abnormal Ca2+-calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism.

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12 December 2020

Free radicals and the pathobiology of brain dopamine systems

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12 December 2020

Glutamate-mediated striatal dysregulation and the pathogenesis of motor response complications in Parkinson's disease

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12 December 2020

An avian model for the reversal of 6-hydroxydopamine induced rotating behaviour by neural grafting

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12 December 2020

Complex deficits on reaction time performance following bilateral intrastriatal 6-OHDA infusion in the rat

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12 December 2020

Extracellular signal-regulated kinase (ERK) controls immediate early gene induction on corticostriatal stimulation.

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12 December 2020

Depletion of central catecholamines reduces pressor responses to arginine vasopressin

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12 December 2020

Localization of N-methyl-D-aspartate receptors in the rat striatum: effects of specific lesions on the [3H]3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid binding

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12 December 2020

Behavioural sensitization in 6-hydroxydopamine lesioned rats involves the dopamine signal transduction: changes in DARPP-32 phosphorylation

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12 December 2020

CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases

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12 December 2020

Bilateral increase of perforated synapses after unilateral dopamine depletion

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12 December 2020

Functional interaction between mGlu 5 and NMDA receptors in a rat model of Parkinson's disease

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12 December 2020

6-hydroxydopamine lesions in anuran amphibians: a new model system for Parkinson's disease?

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12 December 2020

Characterization of enhanced behavioral responses to L-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease

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12 December 2020

Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains.

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12 December 2020

Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set.

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12 December 2020

Treatment with 6-hydroxydopamine in planaria (Dugesia gonocephala s.l.): morphological and behavioral study

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12 December 2020

Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia

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12 December 2020

Priming with L-DOPA differently affects dynorphin and substance P mRNA levels in the striatum of 6-hydroxydopamine-lesioned rats after challenge with dopamine D1-receptor agonist

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12 December 2020

Increased striatal expression of glutamate decarboxylase 67 after priming of 6-hydroxydopamine-lesioned rats.

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12 December 2020

Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex.

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12 December 2020

Priming as a model of behavioural sensitization

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12 December 2020

Reduction of brain glutathione by L-buthionine sulfoximine potentiates the dopamine-depleting action of 6-hydroxydopamine in rat striatum

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12 December 2020

Unilateral dopamine depletion increases expression of the 2A subunit of the N-methyl-D-aspartate receptor in enkephalin-positive and enkephalin-negative neurons

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12 December 2020

Incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats

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12 December 2020

Motor fluctuations in levodopa treated parkinsonian rats: relation to lesion extent and treatment duration

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12 December 2020

D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons

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12 December 2020

Striatal NMDAR2B mRNA expression after bilateral cortical and unilateral nigral deafferentation

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12 December 2020

Selective modifications in GAD67 mRNA levels in striatonigral and striatopallidal pathways correlate to dopamine agonist priming in 6-hydroxydopamine-lesioned rats.

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12 December 2020

NMDA receptor antagonists ameliorate the stepping deficits produced by unilateral medial forebrain bundle injections of 6-OHDA in rats

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12 December 2020

Inhibition of mitochondrial complexes I and IV by 6-hydroxydopamine

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12 December 2020

Dopaminergic denervation of striatum results in elevated expression of NR2A subunit

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12 December 2020

Iron as catalyst for oxidative stress in the pathogenesis of Parkinson's disease?

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12 December 2020

Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: behavioral and biochemical evidence

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12 December 2020

Tyrosine phosphorylation of NMDA receptor in rat striatum: effects of 6-OH-dopamine lesions

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12 December 2020

Parkinson's disease: mechanisms and models

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1007/BF03033565

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16 August 2017

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