(Q36802598)

16 August 2017

1 reference

title

Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents (English)

1 reference

16 August 2017

4

Ian Critchley

1 reference

16 August 2017

Urs A Ochsner

1

1 reference

16 August 2017

Xicheng Sun

series ordinal

2

1 reference

16 August 2017

Thale Jarvis

series ordinal

3

1 reference

16 August 2017

Nebojsa Janjic

series ordinal

5

1 reference

16 August 2017

language of work or name

English

0 references

publication date

1 May 2007

1 reference

Expert Opinion on Investigational Drugs

16 August 2017

published in

1 reference

16 August 2017

volume

16

1 reference

16 August 2017

issue

5

1 reference

16 August 2017

page(s)

573-593

1 reference

Antibacterial drug discovery: is it all downhill from here?

16 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

New advances in antibiotic development and discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Antibacterial drug discovery in the 21st century

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

New aminoacyl-tRNA synthetase inhibitors as antibacterial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Inhibitors of aminoacyl-tRNA synthetases as novel anti-infectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

21 January 2018

Aminoacyl-tRNA synthesis

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Aminoacyl-tRNA synthetases, the genetic code, and the evolutionary process

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Eleven down and nine to go.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Trans-editing of mischarged tRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Charging two for the price of one.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Structural basis for anticodon recognition by discriminating glutamyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Bacterial genomics: potential for antimicrobial drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Direct glutaminyl-tRNA biosynthesis and indirect asparaginyl-tRNA biosynthesis in Pseudomonas aeruginosa PAO1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Species-specific differences in amino acid editing by class II prolyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Substrate recognition by class I lysyl-tRNA synthetases: a molecular basis for gene displacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Discrimination of cognate and noncognate substrates at the active site of class II lysyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Divergence in noncognate amino acid recognition between class I and class II lysyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

The effect of antibiotic treatment on the intracellular nucleotide pools of Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

How does Pseudomonas fluorescens avoid suicide from its antibiotic pseudomonic acid?: Evidence for two evolutionarily distinct isoleucyl-tRNA synthetases conferring self-defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

The antifungal activity of mupirocin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Nasal carriage of Staphylococcus aureus and prevention of nosocomial infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Effect of mupirocin treatment on nasal, pharyngeal, and perineal carriage of Staphylococcus aureus in healthy adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Topical mupirocin for eradication of MRSA colonization with mupirocin-resistant strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Mupirocin-resistant, methicillin-resistant Staphylococcus aureus: does mupirocin remain effective?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Emerging elevated mupirocin resistance rates among staphylococcal isolates in the SENTRY Antimicrobial Surveillance Program (2000): correlations of results from disk diffusion, Etest and reference dilution methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Mutations affecting the Rossman fold of isoleucyl-tRNA synthetase are correlated with low-level mupirocin resistance in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Molecular characterization of the gene encoding high-level mupirocin resistance in Staphylococcus aureus J2870.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Mupirocin resistance in staphylococci: development and transfer of isoleucyl-tRNA synthetase-mediated resistance in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Surveillance for mupirocin resistance following introduction of routine peri-operative prophylaxis with nasal mupirocin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Emergence of resistance during mupirocin treatment: is it a problem in clinical practice?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Low concentrations of mupirocin in the pharynx following intranasal application may contribute to mupirocin resistance in methicillin-resistant Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Mupirocin for controlling methicillin-resistant Staphylococcus aureus: lessons from a decade of use at a university hospital

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

New approaches to reduce Staphylococcus aureus nosocomial infection rates: treating S. aureus nasal carriage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Aminoacyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Aminoacyl-tRNA synthetases database

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Pharmacophore-based virtual screening: the discovery of novel methionyl-tRNA synthetase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Transfer RNA recognition by class I lysyl-tRNA synthetase from the Lyme disease pathogen Borrelia burgdorferi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Potassium functionally replaces the second lysine of the KMSKS signature sequence in human tyrosyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Selective inhibition of divergent seryl-tRNA synthetases by serine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Glutamylsulfamoyladenosine and pyroglutamylsulfamoyladenosine are competitive inhibitors of E. coli glutamyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Synthesis and aminoacyl-tRNA synthetase inhibitory activity of aspartyl adenylate analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

In vivo inhibitors of Escherichia coli phenylalanyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Investigation of bioisosteric effects on the interaction of substrates/ inhibitors with the methionyl-tRNA synthetase from Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Horizontal transfer of drug-resistant aminoacyl-transfer-RNA synthetases of anthrax and Gram-positive pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Major biocontrol of plant tumors targets tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Bases of biocontrol: sequence predicts synthesis and mode of action of agrocin 84, the Trojan horse antibiotic that controls crown gall

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an antiosteoclastic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Trabecular meshwork as a new target for the treatment of glaucoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Novel antifungal beta-amino acids: synthesis and activity against Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Uptake of indolmycin in gram-positive bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Indolmycin inhibits prokaryotic tryptophanyl-tRNA ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

In vitro and in vivo antibacterial activities of TAK-083, an agent for treatment of Helicobacter pylori infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Indolmycin resistance of Streptomyces coelicolor A3(2) by induced expression of one of its two tryptophanyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Antibacterial activity of REP8839, a new antibiotic for topical use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Mode of action and biochemical characterization of REP8839, a novel inhibitor of methionyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

3-D-QSAR study and molecular docking of methionyl-tRNA synthetase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Quorum-sensing-dependent regulation of biosynthesis of the polyketide antibiotic mupirocin in Pseudomonas fluorescens NCIMB 10586.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

Discovering New Classes of Brugia malayi Asparaginyl-tRNA Synthetase Inhibitors and Relating Specificity to Conformational Change

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.5.573

SB-203207 and SB-203208, two novel isoleucyl tRNA synthetase inhibitors from a Streptomyces sp. II. Structure determination

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.364

SB-203207 and SB-203208, two novel isoleucyl tRNA synthetase inhibitors from a Streptomyces sp. I. Fermentation, isolation and properties

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.357

SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp. II. Structure determination

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.351

SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp. I. Fermentation, isolation and properties

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.345

Cispentacin, a new antifungal antibiotic. II. In vitro and in vivo antifungal activities

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.42.1756

Cispentacin, a new antifungal antibiotic. I. Production, isolation, physico-chemical properties and structure

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.42.1749

Identifiers

DOI

10.1517/13543784.16.5.573

1 reference

16 August 2017

1 reference