(Q36809567)

English

Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

scientific article published on 18 April 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

author name string

L Wei

1

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Y Zhou

2

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Q Dai

3

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

C Qiao

4

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

L Zhao

5

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

H Hui

6

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

N Lu

7

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Q-L Guo

8

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

publication date

18 April 2013

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Cell Death and Disease

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

e601

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Breast cancer screening: the evolving evidence

1 reference

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29 September 2017

Hormone therapy and breast cancer risk 10 years after the WHI.

1 reference

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29 September 2017

Links between metabolism and cancer

1 reference

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29 September 2017

Clotrimazole preferentially inhibits human breast cancer cell proliferation, viability and glycolysis

1 reference

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29 September 2017

Targeting glucose metabolism for cancer therapy

1 reference

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29 September 2017

Regulation and protection of mitochondrial physiology by sirtuins.

1 reference

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29 September 2017

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.

1 reference

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29 September 2017

Developing histone deacetylase inhibitors as anti-cancer therapeutics

1 reference

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Mitochondrial glutathione transferases involving a new function for membrane permeability transition pore regulation

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29 September 2017

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

1 reference

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29 September 2017

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

1 reference

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29 September 2017

Different apoptotic effects of wogonin via induction of H(2)O(2) generation and Ca(2+) overload in malignant hepatoma and normal hepatic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

1 reference

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29 September 2017

Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism

1 reference

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29 September 2017

MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Oroxylin A induces G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Mechanisms and molecular probes of sirtuins.

1 reference

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29 September 2017

Regulation of hexokinase binding to VDAC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Uncovering the role of VDAC in the regulation of cell life and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Conserved metabolic regulatory functions of sirtuins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

AsSIRTing the DNA damage response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

A therapeutic role for sirtuins in diseases of aging?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Sirtuins: critical regulators at the crossroads between cancer and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress

1 reference

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29 September 2017

Energy metabolism in tumor cells

1 reference

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Altered sirtuin expression is associated with node-positive breast cancer

1 reference

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29 September 2017

Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Mitochondria and cancer: Warburg addressed

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Flavonoid-induced glutathione depletion: potential implications for cancer treatment

1 reference

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29 September 2017

Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Vitamin B3 and sirtuin function

1 reference

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29 September 2017

Rational development of histone deacetylase inhibitors as anticancer agents: a review

1 reference

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29 September 2017

Calorie restriction--the SIR2 connection

1 reference

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The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension

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29 September 2017

Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells

1 reference

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29 September 2017

The Sir2 family of protein deacetylases

1 reference

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On the Origin of Cancer Cells

1 reference

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The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

1 reference

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29 September 2017

Negative control of p53 by Sir2alpha promotes cell survival under stress

1 reference

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29 September 2017

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

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29 September 2017

Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator

1 reference

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29 September 2017

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641353

29 September 2017

Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway

1 reference

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27 June 2018

Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

1 reference

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5 September 2018

Local delivery of PKCepsilon-activating peptide mimics ischemic preconditioning in aged hearts through GSK-3beta but not F1-ATPase inactivation.

1 reference

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5 September 2018

Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography

1 reference

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5 September 2018

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

1 reference

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5 September 2018

Molecular model of hexokinase binding to the outer mitochondrial membrane porin (VDAC1): Implication for the design of new cancer therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23598413

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention

1 reference

https://pubmed.ncbi.nlm.nih.gov/23598413

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clotrimazole and bifonazole detach hexokinase from mitochondria of melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23598413

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/CDDIS.2013.131

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

ResearchGate publication ID

0 references

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