(Q36815190)

English

The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis

scientific article published on 22 April 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

apoptotic process

1 reference

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inferred from title

Elizabeth Blackburn

5

object named as

Elizabeth H Blackburn

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

1

object named as

Imke Listerman

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Francesca S. Gazzaniga

3

object named as

Francesca S Gazzaniga

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

author name string

Jie Sun

2

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Jason L Lukas

4

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Europe PubMed Central

PMC publication ID

16 August 2017

language of work or name

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publication date

22 April 2013

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Europe PubMed Central

PMC publication ID

16 August 2017

Cancer Research

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Europe PubMed Central

PMC publication ID

16 August 2017

73

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Europe PubMed Central

PMC publication ID

16 August 2017

9

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

2817-2828

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3643995/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Fiji: an open-source platform for biological-image analysis

1 reference

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29 September 2017

Quantification of alternative splicing variants of human telomerase reverse transcriptase and correlations with telomerase activity in lung cancer

1 reference

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Subtype and pathway specific responses to anticancer compounds in breast cancer

1 reference

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29 September 2017

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

1 reference

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29 September 2017

Telomerase modulates Wnt signalling by association with target gene chromatin

1 reference

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29 September 2017

Structure-function relationships in telomerase genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54(nrb).

1 reference

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29 September 2017

Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres

1 reference

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29 September 2017

Telomerase redefined: integrated regulation of hTR and hTERT for telomere maintenance and telomerase activity

1 reference

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29 September 2017

The efficiency of nonsense-mediated mRNA decay is an inherent character and varies among different cells

1 reference

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29 September 2017

Protein composition of catalytically active human telomerase from immortal cells

1 reference

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29 September 2017

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Real-time RT-PCR quantification of human telomerase reverse transcriptase splice variants in tumor cell lines and non-small cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Alternative splicing induced by nonsense mutations in the immunoglobulin mu VDJ exon is independent of truncation of the open reading frame

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

hTERT antagonizes p53-induced apoptosis independently of telomerase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Nonsense-mediated decay approaches the clinic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Tap and NXT promote translation of unspliced mRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

SYBR Green real-time telomeric repeat amplification protocol for the rapid quantification of telomerase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Large-scale analysis of the human and mouse transcriptomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

RNA binding domain of telomerase reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Functional requirement of p23 and Hsp90 in telomerase complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Human telomerase contains evolutionarily conserved catalytic and structural subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Telomeres shorten during ageing of human fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

29 September 2017

Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

27 June 2018

Rapid generation of splicing reporters with pSpliceExpress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

5 September 2018

ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

5 September 2018

Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

5 September 2018

A combined approach for the localization and tandem affinity purification of protein complexes from metazoans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

5 September 2018

Alternative splicing of human telomerase reverse transcriptase may not be involved in telomerase regulation during all-trans-retinoic acid-induced HL-60 cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

5 September 2018

Telomere states and cell fates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

5 September 2018

Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3643995

20 October 2018

Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium

1 reference

https://pubmed.ncbi.nlm.nih.gov/23610451

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TERT regulates cell survival independent of telomerase enzymatic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23610451

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

hTERT associates with human telomeres and enhances genomic stability and DNA repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/23610451

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23610451

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-12-3082

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

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