(Q36821357)

16 August 2017

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title

Immunomodulation as an option for the treatment of chronic hepatitis B virus infection: preclinical studies in the woodchuck model (English)

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16 August 2017

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2

Stephan Menne

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16 August 2017

Mengji Lu

1

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16 August 2017

Dongliang Yang

series ordinal

3

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16 August 2017

Yang Xu

series ordinal

4

1 reference

16 August 2017

Michael Roggendorf

series ordinal

5

1 reference

16 August 2017

language of work or name

English

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publication date

1 June 2007

1 reference

Expert Opinion on Investigational Drugs

16 August 2017

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16 August 2017

16

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16 August 2017

6

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16 August 2017

787-801

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Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial

16 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Agents in clinical development for the treatment of chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Cellular and virological mechanisms of HBV drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Hepatitis B virus immunopathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Rous-Whipple Award Lecture. Viruses, immunity, and cancer: lessons from hepatitis B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Immune responses in hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Immunology of hepatitis B virus and hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Long-lasting memory T cell responses following self-limited acute hepatitis B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Immunotherapy of chronic hepatitis B by anti HBV vaccine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Immunological monitoring during therapeutic vaccination as a prerequisite for the design of new effective therapies: induction of a vaccine-specific CD4+ T-cell proliferative response in chronic hepatitis B carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

In vivo immunization by vaccine therapy following virus suppression by lamivudine: a novel approach for treating patients with chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Treatment of chronic hepatitis B virus infection via oral immune regulation toward hepatitis B virus proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Intrahepatic CD8+ T-lymphocyte response is important for therapy-induced viral clearance in chronic hepatitis B infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Complete nucleotide sequence of a molecular clone of woodchuck hepatitis virus that is infectious in the natural host

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Animal models of hepadnavirus-associated hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

The woodchuck model of hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Evaluation of new approaches to prophylactic and therapeutic vaccinations against hepatitis B viruses in the woodchuck model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Determination of peripheral blood mononuclear cell responses to mitogens and woodchuck hepatitis virus core antigen in woodchucks by 5-bromo-2'-deoxyuridine or 2[3H]adenine incorporation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Hepatitis B virus antigen-specific T-cell activation in patients with acute and chronic hepatitis B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Prospective study of cellular immunity to hepatitis-B-virus antigens from the early incubation phase of acute hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Effects of age and viral determinants on chronicity as an outcome of experimental woodchuck hepatitis virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Deficiencies in the acute-phase cell-mediated immune response to viral antigens are associated with development of chronic woodchuck hepatitis virus infection following neonatal inoculation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Pathogenesis of experimental neonatal woodchuck hepatitis virus infection: chronicity as an outcome of infection is associated with a diminished acute hepatitis that is temporally deficient for the expression of interferon gamma and tumor necrosis f

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Role of type 1 versus type 2 immune responses in liver during the onset of chronic woodchuck hepatitis virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Immunization with recombinant woodchuck hepatitis virus nucleocapsid antigen or hepatitis B virus nucleocapsid antigen protects woodchucks from woodchuck hepatitis virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Protection of woodchucks from infection with woodchuck hepatitis virus by immunization with recombinant core protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Gene-based vaccines and immunotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

DNA vaccines: progress and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

DNA vaccination with plasmids encoding the intracellular (HBcAg) or secreted (HBeAg) form of the core protein of hepatitis B virus primes T cell responses to two overlapping Kb- and Kd-restricted epitopes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Breaking tolerance in hepatitis B surface antigen (HBsAg) transgenic mice by vaccination with cross-reactive, natural HBsAg variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Distinct, cross-reactive epitope specificities of CD8 T cell responses are induced by natural hepatitis B surface antigen variants of different hepatitis B virus genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Protective and therapeutic effect of DNA-based immunization against hepadnavirus large envelope protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Progress in DNA vaccine for prophylaxis and therapy of hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Coadministration of gamma interferon with DNA vaccine expressing woodchuck hepatitis virus (WHV) core antigen enhances the specific immune response and protects against WHV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Protection against woodchuck hepatitis virus (WHV) infection by gene gun coimmunization with WHV core and interleukin-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Immunization with the gene expressing woodchuck hepatitis virus nucleocapsid protein fused to cytotoxic-T-lymphocyte-associated antigen 4 leads to enhanced specific immune responses in mice and woodchucks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Bicistronic woodchuck hepatitis virus core and gamma interferon DNA vaccine can protect from hepatitis but does not elicit sterilizing antiviral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Successful nucleic acid based immunization of newborn chimpanzees against hepatitis B virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

DNA prime/canarypox boost-based immunotherapy of chronic hepatitis B virus infection in a chimpanzee

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV carriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Molecular characterization of CD28 and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) of woodchuck (Marmota monax).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Therapeutic vaccination of woodchucks against chronic woodchuck hepatitis virus infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Induction of antibodies to the PreS region of surface antigens of woodchuck hepatitis virus (WHV) in chronic carrier woodchucks by immunizations with WHV surface antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

T-helper cell response to woodchuck hepatitis virus antigens after therapeutic vaccination of chronically-infected animals treated with lamivudine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Immunogenic effects of woodchuck hepatitis virus surface antigen vaccine in combination with antiviral therapy: breaking of humoral and cellular immune tolerance in chronic woodchuck hepatitis virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)-uracil (L-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Vaccination with recombinant HBsAg-HBIG complex in healthy adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

How cells respond to interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Alpha and beta interferons and their receptor and their friends and relations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

STATs and gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

STAT proteins and transcriptional responses to extracellular signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Expression of a new woodchuck IFN-alpha gene by a helper-dependent adenoviral vector in woodchuck hepatitis virus-infected primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

The woodchuck interferon-alpha system: Cloning, family description, and biologic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Liver-specific alpha 2 interferon gene expression results in protection from induced hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Combination therapy with lamivudine and adenovirus causes transient suppression of chronic woodchuck hepatitis virus infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Helper-dependent adenoviral vector-mediated delivery of woodchuck-specific genes for alpha interferon (IFN-alpha) and IFN-gamma: IFN-alpha but not IFN-gamma reduces woodchuck hepatitis virus replication in chronic infection in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

IFN-alpha gene therapy for woodchuck hepatitis with adeno-associated virus: differences in duration of gene expression and antiviral activity using intraportal or intramuscular routes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Woodchuck gamma interferon upregulates major histocompatibility complex class I transcription but is unable to deplete woodchuck hepatitis virus replication intermediates and RNAs in persistently infected woodchuck primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Posttranscriptional inhibition of class I major histocompatibility complex presentation on hepatocytes and lymphoid cells in chronic woodchuck hepatitis virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Fluctuation of the cytokine expression in the liver during the chronic woodchuck hepatitis virus (WHV) infection is not related to viral load

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Effect of a combination of clevudine and emtricitabine with adenovirus-mediated delivery of gamma interferon in the woodchuck model of hepatitis B virus infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Long-term entecavir treatment results in sustained antiviral efficacy and prolonged life span in the woodchuck model of chronic hepatitis infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Inhibition of hepatitis B virus in mice by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Small interfering RNA Inhibits Hepatitis B virus replication in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Liver-specific expression of interferon gamma following adenoviral gene transfer controls hepatitis B virus replication in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Pathogen recognition and innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Innate immune recognition of viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Restoring function in exhausted CD8 T cells during chronic viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

PD-1 inhibits antiviral immunity at the effector phase in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Waking up T cells to counteract chronic infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Noncytolytic control of viral infections by the innate and adaptive immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.6.787

10.1517/13543784.16.6.787

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference