(Q36830139)

16 August 2017

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title

Effect of HMG-CoA reductase inhibitors on beta-amyloid peptide levels: implications for Alzheimer's disease (English)

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16 August 2017

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2

Kaj Blennow

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16 August 2017

1

Kina Höglund

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16 August 2017

publication date

1 January 2007

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16 August 2017

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16 August 2017

volume

21

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16 August 2017

issue

6

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16 August 2017

page(s)

449-462

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Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice

16 August 2017

cites work

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721060-00002

Membrane protein secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721060-00002

CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721060-00002

Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721060-00002

Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721060-00002

Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721060-00002

The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721060-00002

Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: a population-based study of African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721060-00002

Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721060-00002

APOE genotype, plasma lipids, lipoproteins, and AD in community elderly.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721060-00002

Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721060-00002

Clinico-neuropathological correlation of Alzheimer's disease in a community-based case series

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200721060-00002

Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain

21 January 2018

1 reference

12 December 2020

Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin

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12 December 2020

Pravastatin at 10 mg/day does not decrease plasma levels of either amyloid-β (Aβ) 40 or Aβ 42 in humans

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12 December 2020

The effect of simvastatin treatment on the amyloid precursor protein and brain cholesterol metabolism in patients with Alzheimer's disease

1 reference

12 December 2020

Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans.

1 reference

12 December 2020

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

12 December 2020

Head injury as a risk factor for Alzheimer's disease: the evidence 10 years on; a partial replication.

1 reference

12 December 2020

Plasma levels of amyloid beta proteins did not differ between subjects taking statins and those not taking statins

1 reference

12 December 2020

Use of lipid-lowering drugs in older adults with and without dementia: a community-based epidemiological study

1 reference

12 December 2020

Statins and the risk of dementia

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12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

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12 December 2020

Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study

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12 December 2020

Localization and cell association of C1q in Alzheimer's disease brain

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12 December 2020

Apolipoprotein E and Alzheimer disease

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12 December 2020

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

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12 December 2020

Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide

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12 December 2020

Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease

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12 December 2020

Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease

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12 December 2020

Statins and neuroprotection

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12 December 2020

Elevated blood pressure and Alzheimer's disease.

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12 December 2020

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

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12 December 2020

An 18-year follow-up of overweight and risk of Alzheimer disease

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12 December 2020

APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease

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12 December 2020

Depression as a risk factor for Alzheimer disease: the MIRAGE Study

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12 December 2020

Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations.

1 reference

12 December 2020

Neuropathology of Alzheimer's disease: what is new since A. Alzheimer?

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12 December 2020

Epidemiology of Alzheimer's Disease

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12 December 2020

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

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12 December 2020

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro

1 reference

12 December 2020

Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

1 reference

12 December 2020

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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12 December 2020

Presenile dementia and Alzheimer's disease in mongolism.

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12 December 2020

Statin therapy for Alzheimer's disease: will it work?

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12 December 2020

Cerebrospinal fluid protein biomarkers for Alzheimer's disease

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12 December 2020

Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol

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12 December 2020

Beta-amyloid precursor protein cleavage by a membrane-bound protease

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12 December 2020

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

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12 December 2020

Links between the pathology of Alzheimer's disease and vascular dementia

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12 December 2020

Amyloid plaque core protein in Alzheimer disease and Down syndrome

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12 December 2020

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

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12 December 2020

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

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12 December 2020

Cholesterol metabolism in the brain

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12 December 2020

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

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12 December 2020

Serum lipoprotein levels, statin use, and cognitive function in older women

1 reference

12 December 2020

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

1 reference

12 December 2020

Diet and risk of dementia: Does fat matter?: The Rotterdam Study

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12 December 2020

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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12 December 2020

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported.

1 reference

12 December 2020

APOE genotype, cholesterol level, lipid-lowering treatment, and dementia: the Three-City Study.

1 reference

12 December 2020

Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

1 reference

12 December 2020

Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation

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12 December 2020

Cholesterol decreases secretion of the secreted form of amyloid precursor protein by interfering with glycosylation in the protein secretory pathway

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12 December 2020

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

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12 December 2020

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

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12 December 2020

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

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12 December 2020

Lipid lowering agents are associated with a slower cognitive decline in Alzheimer's disease

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12 December 2020

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

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12 December 2020

Re-assessing the relationship between cholesterol, statins and Alzheimer's disease

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12 December 2020

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12 December 2020

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial

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12 December 2020

Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice

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12 December 2020

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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12 December 2020

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

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12 December 2020

Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.

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12 December 2020

The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo

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12 December 2020

Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol

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12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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12 December 2020

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

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12 December 2020

Cholesterol, copper and Abeta in controls, MCI, AD and the AD cholesterol-lowering treatment trial (ADCLT).

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12 December 2020

Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial

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12 December 2020

Apolipoprotein E and Alzheimer's disease. A role in amyloid catabolism

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12 December 2020

New insights into the pharmacodynamic and pharmacokinetic properties of statins.

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12 December 2020

The C-terminus of the beta protein is critical in amyloidogenesis

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12 December 2020

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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12 December 2020

The role of cholesterol in the biosynthesis of beta-amyloid

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12 December 2020

HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer's disease and why it would be ill-advise to use one that crosses the blood-brain barrier.

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12 December 2020

Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins

1 reference

12 December 2020

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

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12 December 2020

Amyloid, the presenilins and Alzheimer's disease

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12 December 2020

The public health impact of Alzheimer's disease, 2000-2050: potential implication of treatment advances

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12 December 2020

Use of statins in CNS disorders

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12 December 2020

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

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12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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12 December 2020

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

12 December 2020

Apolipoprotein E polymorphism and Alzheimer's disease.

1 reference

12 December 2020

Association between statin use and Alzheimer's disease

1 reference

12 December 2020

Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

1 reference

12 December 2020

Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD.

1 reference

12 December 2020

Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease

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12 December 2020

The prevalence of dementia: a quantitative integration of the literature

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12 December 2020

Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1 reference

12 December 2020

Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide

1 reference

12 December 2020

Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain

1 reference

12 December 2020

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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12 December 2020

A critical review of brain cholesterol metabolism

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12 December 2020

Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein

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12 December 2020

A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation

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12 December 2020

Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia

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12 December 2020

10.2165/00023210-200721060-00002

Identifiers

DOI

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Dimensions Publication ID

16 August 2017

1023284696

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Fatcat ID

release_e6zhjskcdrdppfkofxk73s35lm

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Fatcat

https://api.fatcat.wiki/v0/release/e6zhjskcdrdppfkofxk73s35lm

24 November 2022

mapped directly with Wikidata item

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