(Q36832574)

English

The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs

scientific article published on 27 March 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Hitoshi Nakagama

11

object named as

Hitoshi Nakagama

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Europe PubMed Central

PMC publication ID

16 August 2017

author name string

Yuko Atsumi

1

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Europe PubMed Central

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16 August 2017

Aki Inase

2

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Europe PubMed Central

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16 August 2017

Tomoyuki Osawa

3

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Europe PubMed Central

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16 August 2017

Eiji Sugihara

4

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Europe PubMed Central

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16 August 2017

Ryo Sakasai

5

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Europe PubMed Central

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16 August 2017

Hiroaki Fujimori

6

1 reference

Europe PubMed Central

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16 August 2017

Hirobumi Teraoka

7

1 reference

Europe PubMed Central

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16 August 2017

Hideyuki Saya

8

1 reference

Europe PubMed Central

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16 August 2017

Masamoto Kanno

9

1 reference

Europe PubMed Central

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16 August 2017

Fumio Tashiro

10

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Europe PubMed Central

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16 August 2017

Mitsuko Masutani

12

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Europe PubMed Central

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16 August 2017

Ken-ichi Yoshioka

13

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16 August 2017

language of work or name

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publication date

27 March 2013

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Europe PubMed Central

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16 August 2017

Journal of Biological Chemistry

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16 August 2017

288

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Europe PubMed Central

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16 August 2017

19

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Europe PubMed Central

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16 August 2017

13269-13277

1 reference

Europe PubMed Central

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16 August 2017

Induction of cancerous stem cells during embryonic stem cell differentiation

1 reference

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The quiescent cellular state is Arf/p53-dependent and associated with H2AX downregulation and genome stability

1 reference

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Combining immunotherapy and targeted therapies in cancer treatment

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Topoisomerase I poisoning results in PARP-mediated replication fork reversal

1 reference

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Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells

1 reference

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Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression

1 reference

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Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

1 reference

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Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers

1 reference

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DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development

1 reference

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1 reference

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GammaH2AX and cancer

1 reference

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Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

1 reference

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The p53-mediated cytotoxicity of photodynamic therapy of cancer: recent advances.

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The Arf/p53 pathway in cancer and aging

1 reference

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Predictive factors for chemotherapy-related toxic effects in patients with colorectal cancer.

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The resurgence of platinum-based cancer chemotherapy

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PEFG (cisplatin, epirubicin, 5-fluorouracil, gemcitabine) for patients with advanced pancreatic cancer: the ghost regimen

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p53 induced growth arrest versus apoptosis and its modulation by survival cytokines

1 reference

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MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres

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Topoisomerase I inhibitors: camptothecins and beyond

1 reference

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ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

1 reference

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Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

1 reference

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Drug Insight: Metastatic colorectal cancer--oral fluoropyrimidines and new perspectives in the adjuvant setting

1 reference

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Alteration of radiotherapy fractionation and concurrent chemotherapy: a new frontier in head and neck oncology?

1 reference

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Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage

1 reference

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Adjuvant chemotherapy for stage II colorectal cancer: the time is right!

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Intrinsic tumour suppression

1 reference

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

1 reference

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H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity

1 reference

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Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

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Decision making by p53: life, death and cancer

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29 September 2017

p53: death star

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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1 reference

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27 June 2018

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David A. Karnofsky Award lecture. Imatinib as a paradigm of targeted therapies

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Delayed ageing through damage protection by the Arf/p53 pathway

1 reference

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Mechanisms of p53-mediated apoptosis

1 reference

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12 December 2020

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Identifiers

10.1074/JBC.M112.402560

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

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