(Q57562759)

2

0 references

Manuel Serrano

object named as

Manuel Serrano

10

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Maria A Blasco

object named as

Maria A. Blasco

9

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author name string

Ander Matheu

1

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Peter Klatt

3

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Isabel Garcia-Cao

5

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Consuelo Borras

6

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Juana M. Flores

7

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Jose Viña

https://scigraph.springernature.com/pub.10.1038/nature05949

8

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language of work or name

English

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publication date

July 2007

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published in

Nature

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volume

448

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issue

7151

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page(s)

375-379

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exact match

0 references

cites work

The p53 pathway: positive and negative feedback loops

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Intrinsic tumour suppression

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Mutations that increase the life span of C. elegans inhibit tumor growth.

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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

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Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.

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Increased p53 activity does not accelerate telomere-driven ageing

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Tumor suppression and normal aging in mice with constitutively high p53 activity

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p53 mutant mice that display early ageing-associated phenotypes

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Modulation of mammalian life span by the short isoform of p53.

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Genotype and age influence the effect of caloric intake on mortality in mice

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Genetic mouse models of extended lifespan

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Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span

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Assessing the predictive validity of psychomotor tests as measures of biological age in mice.

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Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

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Cellular senescence in aging primates.

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Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

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p16INK4a induces an age-dependent decline in islet regenerative potential

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

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Extension of murine life span by overexpression of catalase targeted to mitochondria

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p53 in health and disease

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PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

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Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.

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The antioxidant function of the p53 tumor suppressor

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Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

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Structure, mechanism and regulation of peroxiredoxins

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Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

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Relationship between susceptibility to protein oxidation, aging, and maximum life span potential of different species

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Positive correlation between mammalian life span and cellular resistance to stress.

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Regulation of oxidative stress by the anti-aging hormone klotho

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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

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Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

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Induction of senescence by oncogenic Ras.

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Regulation of the INK4a/ARF locus by histone deacetylase inhibitors

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Statistical analysis of real-time PCR data

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Determination of oxidized glutathione in blood: high-performance liquid chromatography

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Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

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