(Q36850426)

16 August 2017

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses (English)

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16 August 2017

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Daniela Kenzelmann Broz

1

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16 August 2017

Stephano Spano Mello

2

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16 August 2017

Kathryn T Bieging

3

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16 August 2017

Dadi Jiang

4

1 reference

16 August 2017

Rachel L Dusek

5

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16 August 2017

Colleen A Brady

6

1 reference

16 August 2017

Arend Sidow

7

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16 August 2017

Laura D Attardi

8

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16 August 2017

1 May 2013

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16 August 2017

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16 August 2017

27

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16 August 2017

9

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16 August 2017

1016-1031

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describes a project that uses

16 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3656320/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells

29 September 2017

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Deconstructing p53 transcriptional networks in tumor suppression

29 September 2017

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Distinct p53 genomic binding patterns in normal and cancer-derived human cells

29 September 2017

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Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression

29 September 2017

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Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

29 September 2017

1 reference

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Pancreatic cancers require autophagy for tumor growth

29 September 2017

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Role of p53 serine 46 in p53 target gene regulation

29 September 2017

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Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

29 September 2017

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Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation

29 September 2017

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Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis

29 September 2017

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Stage-specific sensitivity to p53 restoration during lung cancer progression.

29 September 2017

1 reference

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Differential expression analysis for sequence count data

29 September 2017

1 reference

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Autophagy and the integrated stress response

29 September 2017

1 reference

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p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation.

29 September 2017

1 reference

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Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus.

29 September 2017

1 reference

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Phylogeny and function of the invertebrate p53 superfamily

29 September 2017

1 reference

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C. elegans screen identifies autophagy genes specific to multicellular organisms

29 September 2017

1 reference

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The origins and evolution of the p53 family of genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors

29 September 2017

1 reference

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TP53 mutations in human cancers: origins, consequences, and clinical use

29 September 2017

1 reference

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3'-end sequencing for expression quantification (3SEQ) from archival tumor samples

29 September 2017

1 reference

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In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models

29 September 2017

1 reference

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Autophagy regulation by p53.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Blinded by the Light: The Growing Complexity of p53

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

PUMA- and Bax-induced autophagy contributes to apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

mTOR regulates autophagy-associated genes downstream of p73.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Using RSAT to scan genome sequences for transcription factor binding sites and cis-regulatory modules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Characterization of genome-wide p53-binding sites upon stress response.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Regulation of autophagy by cytoplasmic p53

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Transcriptional control of human p53-regulated genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Genome-wide mapping of in vivo protein-DNA interactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

ASPP: a new family of oncogenes and tumour suppressor genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

A global map of p53 transcription-factor binding sites in the human genome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

The coordinate regulation of the p53 and mTOR pathways in cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Live or let die: the cell's response to p53

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Dissecting p53 tumor suppressor functions in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Fitting a mixture model by expectation maximization to discover motifs in biopolymers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

p53 and ATM: cell cycle, cell death, and cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Autophagy-deficient mice develop multiple liver tumors

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

The role of apoptosis in cancer development and treatment response

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656320

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

5 September 2018

1 reference

12 December 2020

BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)

1 reference

12 December 2020

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

1 reference

12 December 2020

p53-dependent apoptosis suppresses tumor growth and progression in vivo

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.212282.112

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

23651856

1 reference