(Q36869603)

16 August 2017

1 reference

title

p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility (English)

1 reference

16 August 2017

Katherine A Sheehan

1

1 reference

16 August 2017

Yunbo Ke

series ordinal

2

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16 August 2017

R John Solaro

series ordinal

3

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16 August 2017

publication date

3 July 2007

1 reference

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

16 August 2017

published in

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16 August 2017

volume

293

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16 August 2017

issue

3

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16 August 2017

page(s)

R963-73

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PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

16 August 2017

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1 reference

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21 January 2018

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21 January 2018

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Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure

21 January 2018

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Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit

21 January 2018

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A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins

21 January 2018

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Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Protein phosphorylation in cardiac and vascular smooth muscle

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Macromolecular complexes regulating cardiac ryanodine receptor function.

21 January 2018

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Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes

21 January 2018

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Biology of the p21-activated kinases

21 January 2018

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A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Type 1 phosphatase, a negative regulator of cardiac function

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

21 January 2018

1 reference

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Activation of p21-activated protein kinase alpha (alpha PAK) by hyperosmotic shock in neonatal ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

The structure and regulation of protein phosphatases

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Mechanisms of acetylcholine- and bradykinin-induced preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Protein phosphatase 2A is associated with class C L-type calcium channels (Cav1.2) and antagonizes channel phosphorylation by cAMP-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Dynamic modulation of excitation-contraction coupling by protein phosphatases in rat ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

The significance of phosphorylation of myosin light chains in heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

PAK1 and aPKCzeta regulate myosin II-B phosphorylation: a novel signaling pathway regulating filament assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

cGMP-dependent protein kinase phosphorylates p21-activated kinase (Pak) 1, inhibiting Pak/Nck binding and stimulating Pak/vasodilator-stimulated phosphoprotein association

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Regulation of the cardiac ryanodine receptor channel by luminal Ca2+ involves luminal Ca2+ sensing sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Role of protein phosphatase type 1 in contractile functions: myosin phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Regulation of Smooth Muscle Actomyosin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Interaction of paxillin with p21-activated Kinase (PAK). Association of paxillin alpha with the kinase-inactive and the Cdc42-activated forms of PAK3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

p21-activated kinases: three more join the Pak.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

PTPA regulating PP2A as a dual specificity phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

The function of myosin and myosin light chain kinase phosphorylation in smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Regulation of L-type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Phosphorylation of troponin I by protein kinase A accelerates relaxation and crossbridge cycle kinetics in mouse ventricular muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

The p21Rac/Cdc42-activated kinases (PAKs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Structural requirements for PAK activation by Rac GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Calcium, thin filaments, and the integrative biology of cardiac contractility

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Antiadrenergic effects of adenosine A(1) receptor-mediated protein phosphatase 2a activation in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Modulation of protein phosphatase 2a by adenosine A1 receptors in cardiomyocytes: role for p38 MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Calcium-independent contraction and sensitization of airway smooth muscle by p21-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

The 3D structure of protein phosphatase 2A: new insights into a ubiquitous regulator of cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Cdc42 plays a critical role in assembly of sarcomere units in series of cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Evidence for physiological functions of protein phosphatases in the heart: evaluation with okadaic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Modulation of myosin phosphatase targeting subunit and protein phosphatase 1 in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

A-kinase anchoring protein targeting of protein kinase A in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Cardiac myosin-binding protein-C phosphorylation and cardiac function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Inhibition of myosin light chain kinase by p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Lysophosphatidic acid stimulates p21-activated kinase in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Structure and function of the NHE1 isoform of the Na+/H+ exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Purification of a calmodulin-binding protein from chicken gizzard that interacts with F-actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Integration of pathways that signal cardiac growth with modulation of myofilament activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Protein phosphatases decrease sarcoplasmic reticulum calcium content by stimulating calcium release in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Roles of phosphorylation of myosin binding protein-C and troponin I in mouse cardiac muscle twitch dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Modulation of the enzymatic properties of protein phosphatase 2A catalytic subunit by the recombinant 65-kDa regulatory subunit PR65alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Regulation of Rac and Cdc42 pathways by G(i) during lysophosphatidic acid-induced cell spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Rho GTPases and signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Different molecular mechanisms for Rho family GTPase-dependent, Ca2+-independent contraction of smooth muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Inhibition of Contraction and Myosin Light Chain Phosphorylation in Guinea‐Pig Smooth Muscle by p21‐Activated Kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

The immunophilin FK506-binding protein modulates Ca2+ release channel closure in rat heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

p21-Activated Kinase 2 in Neutrophils Can Be Regulated by Phosphorylation at Multiple Sites and by a Variety of Protein Phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Pak1 and its T212 phosphorylated form accumulate in neurones and epithelial cells of the developing rodent

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Akt Phosphorylation of Serine 21 on Pak1 Modulates Nck Binding and Cell Migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

p38-MAPK Induced Dephosphorylation of α-Tropomyosin Is Associated With Depression of Myocardial Sarcomeric Tension and ATPase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00253.2007

10.1152/AJPREGU.00253.2007

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference