(Q36876341)

16 August 2017

1 reference

title

New therapeutic targets in the neurovascular pathway in Alzheimer's disease (English)

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16 August 2017

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Berislav V Zlokovic

1

1 reference

PMCID

2536515

16 August 2017

language of work or name

1 reference

1 July 2008

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16 August 2017

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16 August 2017

5

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16 August 2017

409-414

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16 August 2017

3

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https://scigraph.springernature.com/pub.10.1016/j.nurt.2008.05.011

16 August 2017

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cites work

The blood-brain barrier in health and chronic neurodegenerative disorders

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Clearance of amyloid-beta by circulating lipoprotein receptors

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Role of the Blood-Brain Barrier in the Pathogenesis of Alzheimers Disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Cognitive impact of subcortical vascular and Alzheimer's disease pathology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

A hundred years of Alzheimer's disease research

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

The role of neuronal signaling in controlling cerebral blood flow

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

How do heart disease and stroke become risk factors for Alzheimer's disease?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Regulation of NMDA receptor trafficking by amyloid-beta

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Tau suppression in a neurodegenerative mouse model improves memory function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Neurovascular mechanisms of Alzheimer's neurodegeneration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Amyloid angiopathy-related vascular cognitive impairment.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Inhibition of angiogenesis by Abeta peptides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Neurovascular regulation in the normal brain and in Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Amyloidosis and Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Clearing the brain's amyloid cobwebs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Cerebral microvascular pathology in aging and Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Patterns of brain activation in people at risk for Alzheimer's disease.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Kinetics of arginine-vasopressin uptake at the blood-brain barrier

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine).

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study.

27 June 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Relation of diabetes to mild cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

The synaptic Abeta hypothesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Circle of Willis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tangles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Silent brain infarcts and the risk of dementia and cognitive decline.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Differential changes in phosphorylation of tau at PHF-1 and 12E8 epitopes during brain ischemia and reperfusion in gerbils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

beta-Amyloid-mediated vasoactivity and vascular endothelial damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Clearance of amyloid beta-peptide from brain: transport or metabolism?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Environmental enrichment counteracts Alzheimer's neurovascular dysfunction in TgCRND8 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2536515

Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

4 September 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.NURT.2008.05.011

Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease

21 January 2018

1 reference

12 December 2020

RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier

1 reference

12 December 2020

Kinetics and Na independence of amino acid uptake by blood side of perfused sheep choroid plexus

1 reference

12 December 2020

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

1 reference

12 December 2020

Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver

1 reference

12 December 2020

10.1016/J.NURT.2008.05.011

Identifiers

DOI

1 reference

PMCID

2536515

Dimensions Publication ID

16 August 2017

0 references

1 reference

16 August 2017

1 reference

PMCID

2536515