(Q46084979)

English

Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein.

scientific article published in November 2002

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scholarly article

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/12417655

Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

neurodegeneration

1 reference

based on heuristic

inferred from title

Edward Rockenstein

5

object named as

Edward Rockenstein

2 references

Europe PubMed Central

PubMed publication ID

19 December 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

Eliezer Masliah

6

object named as

Eliezer Masliah

2 references

Europe PubMed Central

PubMed publication ID

19 December 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

author name string

Emily Van Uden

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

Margaret Mallory

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

Isaac Veinbergs

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

Michael Alford

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

language of work or name

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publication date

1 November 2002

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/12417655

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

22

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

21

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

9298-9304

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6758061/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Activated alpha2macroglobulin increases beta-amyloid (25-35)-induced toxicity in LAN5 human neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel role for receptor-associated protein in somatostatin modulation: implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mammalian low-density lipoprotein receptor family

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant presenilin-1 expression downregulates LDL receptor-related protein (LRP): is LRP central to Alzheimer's disease pathogenesis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of expression of genes involved in apolipoprotein E-based lipoprotein metabolism in pregnant mice deficient in the receptor-associated protein, the low density lipoprotein receptor, or apolipoprotein E

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protective role of the low density lipoprotein receptor-related protein against amyloid beta-protein toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E receptors mediate the effects of beta-amyloid on astrocyte cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances in the understanding of the processing of APP to beta amyloid peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxic traffic: uncovering the mechanics of amyloid production in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoprotein receptors: beacons to neurons?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E receptors: linking brain development and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The LDL receptor gene family: (un)expected signal transducers in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VLDL receptor polymorphism, cognitive impairment, and dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LRP: a multifunctional scavenger and signaling receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha 2-macroglobulin, a multifunctional binding protein with targeting characteristics

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlations of synaptic and pathological markers with cognition of the elderly

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative assessment of the synaptophysin immuno-reactivity of the cortical neuropil in various neurodegenerative disorders with dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of APP processing and trafficking pathways in the formation of amyloid beta-protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the very low-density lipoprotein receptor (VLDL-r), an apolipoprotein-E receptor, in the central nervous system and in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-associated protein: a specialized chaperone and antagonist for members of the LDL receptor gene family

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12417655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-21-09298.2002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758061&resulttype=core&format=json

12 May 2020

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