(Q34180114)

31 July 2017

1 reference

title

Neurotoxic traffic: uncovering the mechanics of amyloid production in Alzheimer's disease (English)

1 reference

31 July 2017

0 references

1 reference

Huse JT

1

1 reference

PubMed ID

11247305

31 July 2017

Doms RW

series ordinal

2

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31 July 2017

1 February 2001

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31 July 2017

1 reference

31 July 2017

2

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31 July 2017

2

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31 July 2017

75-81

1 reference

Translating cell biology into therapeutic advances in Alzheimer's disease

31 July 2017

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Genetic risk factors in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Maturation and pro-peptide cleavage of beta-secretase

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Expression analysis of BACE2 in brain and peripheral tissues

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Protein topology of presenilin 1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Membrane topology of the C. elegans SEL-12 presenilin

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Evidence for a six-transmembrane domain structure of presenilin 1.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Mutant genes in familial Alzheimer's disease and transgenic models

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Intraneuronal Abeta42 accumulation in human brain.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2001.020201.X

7 January 2021

10.1034/J.1600-0854.2001.020201.X

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11247305