(Q36895458)

English

Phosphatidylserine-targeting antibodies augment the anti-tumorigenic activity of anti-PD-1 therapy by enhancing immune activation and downregulating pro-oncogenic factors induced by T-cell checkpoint inhibition in murine triple-negative breast cance

scientific article published on 11 May 2016

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Europe PubMed Central

PMC publication ID

16 August 2017

Phosphatidylserine-targeting antibodies augment the anti-tumorigenic activity of anti-PD-1 therapy by enhancing immune activation and downregulating pro-oncogenic factors induced by T-cell checkpoint inhibition in murine triple-negative breast cance (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

author name string

Michael J Gray

1

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Jian Gong

2

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Michaela M S Hatch

3

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Van Nguyen

4

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Christopher C W Hughes

5

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Jeff T Hutchins

6

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Bruce D Freimark

7

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Europe PubMed Central

PMC publication ID

16 August 2017

language of work or name

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inferred from title

publication date

11 May 2016

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Europe PubMed Central

PMC publication ID

16 August 2017

Breast Cancer Research

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Europe PubMed Central

PMC publication ID

16 August 2017

18

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Europe PubMed Central

PMC publication ID

16 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

50

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Prognostic significance of PD-L1 and PD-L2 in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Relevance of tumor-infiltrating lymphocytes in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Molecular characterization and targeted therapeutic approaches in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Robust enumeration of cell subsets from tissue expression profiles

1 reference

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29 September 2017

Management of locally advanced breast cancer-perspectives and future directions

1 reference

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29 September 2017

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

1 reference

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29 September 2017

Tumor-infiltrating CD8+ and FOXP3+ lymphocytes in triple-negative breast cancer: its correlation with pathological complete response to neoadjuvant chemotherapy

1 reference

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29 September 2017

Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid T-cell sensitization and rejection of progressive tumor challenges

1 reference

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29 September 2017

The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.

1 reference

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29 September 2017

B7-H1/PD-1 blockade therapy in non-small cell lung cancer: current status and future direction

1 reference

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29 September 2017

IL4 receptor ILR4α regulates metastatic colonization by mammary tumors through multiple signaling pathways

1 reference

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29 September 2017

Chronic inflammation and cytokines in the tumor microenvironment

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29 September 2017

Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer

1 reference

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29 September 2017

Phosphatidylserine-targeting antibody induces M1 macrophage polarization and promotes myeloid-derived suppressor cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

PD-L1 expression in triple-negative breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

IL-13Rα2 mediates PNR-induced migration and metastasis in ERα-negative breast cancer

1 reference

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29 September 2017

Cancer statistics, 2014

1 reference

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29 September 2017

Cytokines in cancer immunotherapy

1 reference

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29 September 2017

High-infiltration of tumor-associated macrophages predicts unfavorable clinical outcome for node-negative breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Deciphering and reversing tumor immune suppression.

1 reference

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29 September 2017

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Macrophages in tumor microenvironments and the progression of tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

T-regulatory cells: key players in tumor immune escape and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Current management and treatment strategies for breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Role of interleukin-10 in breast cancer.

1 reference

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29 September 2017

Targeted therapies for breast cancer

1 reference

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29 September 2017

Development of bavituximab, a vascular targeting agent with immune-modulating properties, for lung cancer treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Triple-negative breast cancer: an unmet medical need

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

The PD-1 pathway in tolerance and autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Targeting phosphatidylserine in anti-cancer therapy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

The HER-2 receptor and breast cancer: ten years of targeted anti-HER-2 therapy and personalized medicine

1 reference

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29 September 2017

Survival outcomes for patients with metastatic triple-negative breast cancer: implications for clinical practice and trial design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

PD-1 and its ligands in tolerance and immunity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Epidemiology of basal-like breast cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

A monoclonal antibody that binds anionic phospholipids on tumor blood vessels enhances the antitumor effect of docetaxel on human breast tumors in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Increased exposure of anionic phospholipids on the surface of tumor blood vessels.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Cancer immunoediting: from immunosurveillance to tumor escape

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29 September 2017

Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

29 September 2017

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes

1 reference

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29 September 2017

Interferons: from molecular biology to man. Part 3. Interferons and disease.

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29 September 2017

Interferon gamma and tumor necrosis factor have a role in tumor regressions mediated by murine CD8+ tumor-infiltrating lymphocytes

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29 September 2017

nCounter(®) PanCancer Immune Profiling Panel (NanoString Technologies, Inc., Seattle, WA).

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27 June 2018

IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment

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27 June 2018

Targeting PD-1/PD-L1 interactions for cancer immunotherapy

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27 June 2018

Tumour-infiltrating macrophages and clinical outcome in breast cancer.

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27 June 2018

The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer.

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4 September 2018

Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.

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4 September 2018

Phase I safety and pharmacokinetic study of bavituximab, a chimeric phosphatidylserine-targeting monoclonal antibody, in patients with advanced solid tumors.

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4 September 2018

Antiphosphatidylserine antibody combined with irradiation damages tumor blood vessels and induces tumor immunity in a rat model of glioblastoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

4 September 2018

Combination of a monoclonal anti-phosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864933

4 September 2018

Radiation-Enhanced Vascular Targeting of Human Lung Cancers in Mice with a Monoclonal Antibody That Binds Anionic Phospholipids

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https://api.crossref.org/works/10.1186%2FS13058-016-0708-2

21 January 2018

A role of interferon-gamma (IFN-gamma) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-gamma-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27169467

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Annexin-V promotes anti-tumor immunity and inhibits neuroblastoma growth in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/27169467

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S13058-016-0708-2

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

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