(Q28117255)

negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Adam Cotty

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Brian Tomkowicz

1

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Eileen Walsh

2

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Raluca Verona

4

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Nina Sabins

5

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Fred Kaplan

6

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Sandy Santulli-Marotto

7

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Chen-Ni Chin

8

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Jill Mooney

9

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Michael Naso

11

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Timothy McCabe

12

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Russell B Lingham

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

language of work or name

English

0 references

publication date

1 January 2015

1 reference

4 January 2017

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

10

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

issue

10

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

page(s)

e0140694

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

5 June 2020

copyright license

start time

22 October 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

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Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

20 March 2017

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A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9

20 March 2017

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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

20 March 2017

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20 March 2017

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T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases

20 March 2017

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Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape

20 March 2017

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7 April 2017

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Differential activation of transcription factors induced by Ca2+ response amplitude and duration

7 April 2017

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PD-1/SHP-2 inhibits Tc1/Th1 phenotypic responses and the activation of T cells in the tumor microenvironment

7 April 2017

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PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8⁺ T cells induced by melanoma vaccines

29 September 2017

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29 September 2017

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TIM3(+)FOXP3(+) regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer

29 September 2017

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TIM-3 does not act as a receptor for galectin-9.

29 September 2017

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Enhanced Tim3 activity improves survival after influenza infection

29 September 2017

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Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.

29 September 2017

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Prospects for TIM3-Targeted Antitumor Immunotherapy

29 September 2017

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Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.

29 September 2017

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Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

29 September 2017

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Galectin-9 regulates T helper cell function independently of Tim-3.

29 September 2017

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29 September 2017

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Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients

29 September 2017

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Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

29 September 2017

1 reference

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TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4619610

Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells

29 September 2017

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PD-1 signaling in primary T cells

29 September 2017

1 reference

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Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation

29 September 2017

1 reference

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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

29 September 2017

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Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4619610

Tailoring T-cell receptor signals by proximal negative feedback mechanisms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4619610

TIM-3 as a therapeutic target in human inflammatory diseases

29 September 2017

1 reference

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Characterization of galectin-9-induced death of Jurkat T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4619610

PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4619610

SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4619610

Jurkat T cells and development of the T-cell receptor signalling paradigm

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4619610

Adaptors as central mediators of signal transduction in immune cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4619610

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4619610

The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4619610

TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells

29 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0140694

Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0140694

Modulation of CD40L antigen expression in Jurkat cells: involvement of protein kinase C activity.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4619610

Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26492563

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Down-regulation of interleukin-2 production by CD4(+) T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26492563

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0140694

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

ADS bibcode

2015PLoSO..1040694T

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492563%20AND%20SRC:MED&resulttype=core&format=json