(Q37252710)

19 August 2017

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title

Tailoring T-cell receptor signals by proximal negative feedback mechanisms (English)

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19 August 2017

Oreste Acuto

1

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19 August 2017

Vincenzo Di Bartolo

series ordinal

2

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19 August 2017

Frédérique Michel

series ordinal

3

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19 August 2017

publication date

1 September 2008

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Nature Reviews Immunology

19 August 2017

published in

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19 August 2017

volume

8

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19 August 2017

issue

9

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19 August 2017

page(s)

699-712

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CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.

19 August 2017

cites work

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Alternative modes of binding of proteins with tandem SH2 domains

21 January 2018

1 reference

Cutting edge: dependence of TCR antagonism on Src homology 2 domain-containing protein tyrosine phosphatase activity

21 January 2018

1 reference

Common themes in the assembly and architecture of activating immune receptors

21 January 2018

1 reference

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

31 March 2020

1 reference

Adaptors as central mediators of signal transduction in immune cells

31 March 2020

1 reference

T cell activation and the cytoskeleton

31 March 2020

1 reference

Multistep pathogenesis of autoimmune disease.

31 March 2020

1 reference

31 March 2020

The B7 family revisited

1 reference

T cells as a self-referential, sensory organ

31 March 2020

1 reference

Quantitative challenges in understanding ligand discrimination by alphabeta T cells

31 March 2020

1 reference

Ligand recognition by alpha beta T cell receptors

31 March 2020

1 reference

T-cell receptor binding kinetics in T-cell development and activation

31 March 2020

1 reference

alpha beta T cell receptor ligand-specific oligomerization revisited

31 March 2020

1 reference

T cell receptor antagonist peptides induce positive selection

31 March 2020

1 reference

A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex

31 March 2020

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

31 March 2020

1 reference

Kinetic proofreading in T-cell receptor signal transduction

31 March 2020

1 reference

New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cells

31 March 2020

1 reference

Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist

31 March 2020

1 reference

Direct observation of ligand recognition by T cells.

31 March 2020

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

31 March 2020

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Cell signaling by receptor tyrosine kinases

31 March 2020

1 reference

The kinetic-segregation model: TCR triggering and beyond

31 March 2020

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High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

31 March 2020

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Membrane domains in lymphocytes - from lipid rafts to protein scaffolds

31 March 2020

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Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells

31 March 2020

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PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

31 March 2020

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TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

31 March 2020

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miR-181a is an intrinsic modulator of T cell sensitivity and selection

31 March 2020

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Negative regulation of immunoreceptor signaling

31 March 2020

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Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation

31 March 2020

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PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes

31 March 2020

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The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function

31 March 2020

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The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses

31 March 2020

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CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

31 March 2020

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CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision

31 March 2020

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TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts

31 March 2020

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CD45: a critical regulator of signaling thresholds in immune cells

31 March 2020

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Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45.

31 March 2020

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The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations

31 March 2020

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Structural basis for the inhibition of tyrosine kinase activity of ZAP-70

31 March 2020

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ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

31 March 2020

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Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules

31 March 2020

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Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

31 March 2020

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Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

31 March 2020

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Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection

31 March 2020

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Persistence of cooperatively stabilized signaling clusters drives T-cell activation

31 March 2020

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Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

31 March 2020

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CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

31 March 2020

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A role for CD5 in TCR-mediated signal transduction and thymocyte selection

31 March 2020

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Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

31 March 2020

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Nonreceptor protein-tyrosine phosphatases in immune cell signaling

31 March 2020

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Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness

31 March 2020

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Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

31 March 2020

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Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling

31 March 2020

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Dok-1 and Dok-2 are negative regulators of T cell receptor signaling

31 March 2020

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T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2

31 March 2020

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Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes

31 March 2020

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Role of Dok-1 and Dok-2 in leukemia suppression

31 March 2020

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Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia

31 March 2020

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T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses

31 March 2020

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p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

31 March 2020

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Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.

31 March 2020

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Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis

31 March 2020

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31 March 2020

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Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

31 March 2020

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Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT.

31 March 2020

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Inhibitory adaptors in lymphocytes

31 March 2020

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HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway

31 March 2020

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HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1.

31 March 2020

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Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death

31 March 2020

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Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling

31 March 2020

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Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes

31 March 2020

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Functional interactions of HPK1 with adaptor proteins

31 March 2020

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Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1.

31 March 2020

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Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis

31 March 2020

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A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.

31 March 2020

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Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses

31 March 2020

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Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

31 March 2020

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Immunity by ubiquitylation: a reversible process of modification

31 March 2020

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Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b

31 March 2020

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Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.

31 March 2020

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TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin

31 March 2020

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Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

31 March 2020

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Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2

31 March 2020

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A Phosphatase Activity of Sts-1 Contributes to the Suppression of TCR Signaling

31 March 2020

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Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases

31 March 2020

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How regulated protein translocation can produce switch-like responses

31 March 2020

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Robustness of cellular functions

31 March 2020

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Feedback control of T-cell receptor activation.

31 March 2020

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Modeling T cell antigen discrimination based on feedback control of digital ERK responses

31 March 2020

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Understanding specificity and sensitivity of T-cell recognition.

31 March 2020

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Cross-antagonism of a T cell clone expressing two distinct T cell receptors

31 March 2020

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On the role of self-recognition in T cell responses to foreign antigen

31 March 2020

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The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

31 March 2020

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Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate

31 March 2020

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Interlinked fast and slow positive feedback loops drive reliable cell decisions

31 March 2020

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Superfamilies of evolved and designed networks.

31 March 2020

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Network biology: understanding the cell's functional organization

31 March 2020

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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

31 March 2020

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Mathematical and computational models of immune-receptor signalling

31 March 2020

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Cooperative enhancement of specificity in a lattice of T cell receptors

31 March 2020

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Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment

31 March 2020

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Calcium signaling mechanisms in T lymphocytes

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2397

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Dimensions Publication ID

19 August 2017

1014712591

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