(Q36328809)

13 August 2017

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title

Immunity by ubiquitylation: a reversible process of modification (English)

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13 August 2017

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3

Michael Karin

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13 August 2017

Yun-Cai Liu

1

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Josef Penninger

object named as

Josef Penninger

series ordinal

2

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publication date

1 December 2005

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Nature Reviews Immunology

13 August 2017

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13 August 2017

5

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13 August 2017

941-952

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13 August 2017

12

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Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis

13 August 2017

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Mechanisms underlying ubiquitination

21 January 2018

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Themes and variations on ubiquitylation

21 January 2018

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Ubiquitin ligases and the immune response

21 January 2018

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Protein regulation by monoubiquitin

21 January 2018

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

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Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells

21 January 2018

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Back to central tolerance

21 January 2018

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The enemy within: keeping self-reactive T cells at bay in the periphery

21 January 2018

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Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

21 January 2018

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Positional cloning of the APECED gene

21 January 2018

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Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla.

21 January 2018

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Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

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Aire regulates negative selection of organ-specific T cells

21 January 2018

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Chromosomal clustering of genes controlled by the aire transcription factor

21 January 2018

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The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein

21 January 2018

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The autoimmune regulator (AIRE) is a DNA-binding protein

21 January 2018

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PHD domains and E3 ubiquitin ligases: viruses make the connection

21 January 2018

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AIRE functions as an E3 ubiquitin ligase

21 January 2018

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NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease

21 January 2018

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Genes involved in T-cell receptor-mediated apoptosis of thymocytes and T-cell hybridomas

21 January 2018

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Signals involved in thymocyte positive and negative selection

21 January 2018

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A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

21 January 2018

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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

21 January 2018

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Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

21 January 2018

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Cbl: many adaptations to regulate protein tyrosine kinases

21 January 2018

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 January 2018

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

21 January 2018

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Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase.

21 January 2018

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21 January 2018

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Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways

21 January 2018

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GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells

21 January 2018

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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

21 January 2018

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Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

21 January 2018

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Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

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Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

21 January 2018

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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

21 January 2018

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Control of mRNA decay by heat shock-ubiquitin-proteasome pathway

21 January 2018

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The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

21 January 2018

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Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

21 January 2018

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Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

21 January 2018

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Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB.

21 January 2018

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Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

21 January 2018

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JNK is required for effector T-cell function but not for T-cell activation

21 January 2018

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

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Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches

21 January 2018

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JNK is involved in signal integration during costimulation of T lymphocytes.

21 January 2018

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Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase

21 January 2018

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The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

21 January 2018

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NF-kappaB signaling pathways in mammalian and insect innate immunity

21 January 2018

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Missing pieces in the NF-kappaB puzzle

21 January 2018

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TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

21 January 2018

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The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

21 January 2018

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The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling

21 January 2018

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Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

21 January 2018

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Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

21 January 2018

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Perspectives on PKCtheta in T cell activation

21 January 2018

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PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation

21 January 2018

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NF-kappaB at the crossroads of life and death

21 January 2018

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The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

21 January 2018

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Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

21 January 2018

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Otubains: a new family of cysteine proteases in the ubiquitin pathway

21 January 2018

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A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae

21 January 2018

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

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The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

21 January 2018

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Toll signaling: RIPping off the TNF pathway

21 January 2018

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RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

21 January 2018

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

21 January 2018

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The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

21 January 2018

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CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

21 January 2018

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Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

21 January 2018

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Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation

21 January 2018

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Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation

21 January 2018

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Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression.

21 January 2018

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

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Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

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Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

21 January 2018

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TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

21 January 2018

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

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SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

21 January 2018

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Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

21 January 2018

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Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

21 January 2018

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

21 January 2018

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

21 January 2018

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Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

21 January 2018

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The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

21 January 2018

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Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

21 January 2018

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The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

21 January 2018

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The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein

21 January 2018

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Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein

21 January 2018

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High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction

21 January 2018

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UBP43 (USP18) specifically removes ISG15 from conjugated proteins

21 January 2018

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Protein ISGylation modulates the JAK-STAT signaling pathway

21 January 2018

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Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection.

21 January 2018

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ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus

21 January 2018

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The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase

21 January 2018

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Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

21 January 2018

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

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Blocked Ras activation in anergic CD4+ T cells

21 January 2018

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Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

31 March 2020

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Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation

31 March 2020

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Suppressors of cytokine signalling (SOCS) in the immune system

31 March 2020

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Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence

31 March 2020

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12 December 2020

Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus.

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12 December 2020

The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein

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12 December 2020

Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin

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12 December 2020

Identifiers

DOI

10.1038/NRI1731

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13 August 2017

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PubMed ID

16322747