(Q36541612)

14 August 2017

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title

The kinetic-segregation model: TCR triggering and beyond (English)

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Philip Anton van der Merwe

14 August 2017

series ordinal

2

object named as

P Anton van der Merwe

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14 August 2017

Simon J Davis

1

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PubMed ID

16855606

14 August 2017

language of work or name

English

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publication date

1 August 2006

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14 August 2017

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14 August 2017

7

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14 August 2017

803-809

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14 August 2017

8

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Nothing in Biology Makes Sense except in the Light of Evolution

14 August 2017

1 reference

7 January 2021

An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex

1 reference

7 January 2021

Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

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7 January 2021

Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.

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7 January 2021

Electron diffraction analysis of the M412 intermediate of bacteriorhodopsin

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7 January 2021

Signal transduction by receptors with tyrosine kinase activity

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7 January 2021

At grips with interactions

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7 January 2021

Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling

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7 January 2021

T-cell receptor-CD4 physical association in a murine T-cell hybridoma: induction by antigen receptor ligation

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7 January 2021

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

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7 January 2021

Adhesion receptors of the immune system

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7 January 2021

Topology of the CD2-CD48 cell-adhesion molecule complex: implications for antigen recognition by T cells

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7 January 2021

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase

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7 January 2021

CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development

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7 January 2021

The structure and ligand interactions of CD2: implications for T-cell function

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7 January 2021

Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition

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7 January 2021

A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts

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7 January 2021

Making the T cell receptor go the distance: a topological view of T cell activation

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7 January 2021

Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation

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7 January 2021

Kinetic proofreading in T-cell receptor signal transduction

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7 January 2021

The immunological synapse balances T cell receptor signaling and degradation

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7 January 2021

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

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7 January 2021

Three-dimensional segregation of supramolecular activation clusters in T cells

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7 January 2021

The immunological synapse: a molecular machine controlling T cell activation

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7 January 2021

A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

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7 January 2021

Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes

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7 January 2021

The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling

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7 January 2021

Staging and resetting T cell activation in SMACs

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7 January 2021

T cell receptor signaling precedes immunological synapse formation

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7 January 2021

Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

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7 January 2021

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

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7 January 2021

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

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7 January 2021

T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.

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7 January 2021

CD28-mediated activation of resting human T cells without costimulation of the CD3/TCR complex.

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7 January 2021

CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28

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7 January 2021

Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists

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7 January 2021

Crystal structure of a soluble CD28-Fab complex

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7 January 2021

Protein tyrosine phosphatases in the human genome

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7 January 2021

Cell signaling by receptor tyrosine kinases

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7 January 2021

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells

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7 January 2021

Immunology: how do T cells recognize antigen?

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7 January 2021

The TCR triggering puzzle

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7 January 2021

How T cells 'see' antigen

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7 January 2021

Deconstructing the form and function of the TCR/CD3 complex

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7 January 2021

A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex

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7 January 2021

Initiation of TCR signalling revisited

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7 January 2021

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

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7 January 2021

Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8.

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7 January 2021

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

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7 January 2021

Self peptide/MHC class I complexes have a negligible effect on the response of some CD8+ T cells to foreign antigen

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7 January 2021

The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function

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7 January 2021

B7-independent inhibition of T cells by CTLA-4.

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7 January 2021

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

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7 January 2021

Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells

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7 January 2021

Systematic identification of immunoreceptor tyrosine-based inhibitory motifs in the human proteome

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7 January 2021

Direct observation of ligand recognition by T cells.

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7 January 2021

TCR triggering: co-receptor-dependent or -independent?

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7 January 2021

Identifiers

DOI

10.1038/NI1369

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14 August 2017

1 reference

PubMed ID

16855606