(Q36898033)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

title

Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

main subject

Machado-Joseph disease

1 reference

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Vitor Carmona

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Luis Pereira De Almeida

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Claudia Cavadas

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

author name string

Janete Cunha-Santos

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Leonard Guarente

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

publication date

11 May 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

page(s)

11445

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

4 April 2020

copyright license

start time

11 May 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms11445

0 references

cites work

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A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration

29 September 2017

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Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease

29 September 2017

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Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration

29 September 2017

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Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

29 September 2017

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Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.

29 September 2017

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New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado-Joseph disease).

29 September 2017

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

29 September 2017

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Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription

29 September 2017

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Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

29 September 2017

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Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

29 September 2017

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Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

29 September 2017

1 reference

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

29 September 2017

1 reference

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

29 September 2017

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

29 September 2017

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Sir2: an NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging

29 September 2017

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Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

29 September 2017

1 reference

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

29 September 2017

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An isoform of ataxin-3 accumulates in the nucleus of neuronal cells in affected brain regions of SCA3 patients.

29 September 2017

1 reference

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Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain

29 September 2017

1 reference

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Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

29 September 2017

1 reference

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CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

29 September 2017

1 reference

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Correlation between CAG repeat length and clinical features in Machado-Joseph disease

29 September 2017

1 reference

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The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake

29 September 2017

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29 September 2017

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Autosomal dominant system degeneration in Portuguese families of the Azores Islands. A new genetic disorder involving cerebellar, pyramidal, extrapyramidal and spinal cord motor functions

29 September 2017

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Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

29 September 2017

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Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice

27 June 2018

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Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865854

Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865854

Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865854

Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865854

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865854

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865854

Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865854

Autosomal dominant cerebellar ataxia type I. MRI-based volumetry of posterior fossa structures and basal ganglia in spinocerebellar ataxia types 1, 2 and 3.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865854

Spinocerebellar ataxia 3 and Machado-Joseph disease: clinical, molecular, and neuropathological features.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865854

Genetic Linkage Studies of Machado-Joseph Disease with Chromosome 14q STRPs in 16 Portuguese-Azorean Kindreds

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS11445

Molecular features of the CAG repeats and clinical manifestation of Machado--Joseph disease

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS11445

Dietary restriction slows the abnormally rapid loss of spiral ganglion neurons in C57BL/6 mice

21 January 2018

1 reference

12 December 2020

Spinocerebellar ataxia, type 3 (SCA3) is genetically identical to Machado-Joseph disease (MJD)

1 reference

12 December 2020

Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells

1 reference

12 December 2020

SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS11445

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27165717%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

1 reference