(Q48424712)

English

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.

scientific article published in August 2012

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease. (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

1 reference

based on heuristic

inferred from title

4

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

Carlos B. Duarte

6

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

Luis Pereira De Almeida

7

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

Nélio Gonçalves

object named as

Nélio Gonçalves

2

0 references

Sebastian Kügler

5

object named as

Sebastian Kügler

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

author name string

Ana T Simões

1

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

Arnulf Koeppen

3

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

language of work or name

0 references

publication date

1 August 2012

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

135

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

Pt 8

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

2428-2439

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Identification and functional dissection of localization signals within ataxin-3.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Differential transgene expression in brain cells in vivo and in vitro from AAV-2 vectors with small transcriptional control units.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Calpain in the CNS: from synaptic function to neurotoxicity

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Nucleocytoplasmic shuttling activity of ataxin-3.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Molecular basis for specificity of nuclear import and prediction of nuclear localization

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Ataxin-3 is subject to autolytic cleavage.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Proteotoxic stress increases nuclear localization of ataxin-3

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

An isoform of ataxin-3 accumulates in the nucleus of neuronal cells in affected brain regions of SCA3 patients.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Promoters and serotypes: targeting of adeno-associated virus vectors for gene transfer in the rat central nervous system in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

The roles of proteolysis and nuclear localisation in the toxicity of the polyglutamine diseases. A review

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWS177

21 January 2018

Identifiers

10.1093/BRAIN/AWS177

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/22843411

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q48424712&oldid=1742859612"