(Q33673755)

28 July 2017

title

Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control (English)

1 reference

28 July 2017

4

Ullrich Wüllner

1 reference

28 July 2017

Peter Breuer

1

1 reference

28 July 2017

Annette Haacke

series ordinal

2

1 reference

28 July 2017

Bernd O Evert

series ordinal

3

1 reference

28 July 2017

language of work or name

English

0 references

publication date

11 January 2010

1 reference

Journal of Biological Chemistry

28 July 2017

published in

1 reference

28 July 2017

volume

285

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28 July 2017

issue

9

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28 July 2017

page(s)

6532-6537

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Proteotoxic stress increases nuclear localization of ataxin-3

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Polyglutamine gene function and dysfunction in the ageing brain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Nuclear polyglutamine-containing protein aggregates as active proteolytic centers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

The degree of macromolecular crowding in the cytoplasm and nucleoplasm of mammalian cells is conserved

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Comparison of intra-organellar chaperone capacity for dealing with stress-induced protein unfolding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

The proteasome and its role in nuclear protein maintenance.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Progressive disruption of cellular protein folding in models of polyglutamine diseases.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Pathways of chaperone-mediated protein folding in the cytosol

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Principles of protein folding, misfolding and aggregation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

The nuclear matrix is a thermolabile cellular structure

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Geldanamycin restores a defective heat shock response in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

The selective vulnerability of nerve cells in Huntington's disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Scrapie prions selectively modify the stress response in neuroblastoma cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Multiple layers of regulation of human heat shock transcription factor 1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825449

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.036335

Amino acids in a region of ataxin-1 outside of the polyglutamine tract influence the course of disease in SCA1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.036335

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.036335

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.036335

hsp70: nuclear concentration during environmental stress and cytoplasmic storage during recovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.036335

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.036335

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.036335

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.036335

Ataxin-3 is translocated into the nucleus for the formation of intranuclear inclusions in normal and Machado-Joseph disease brains

21 January 2018

1 reference

12 December 2020

The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease

1 reference

12 December 2020

Thermostability of a nuclear-targeted luciferase expressed in mammalian cells. Destabilizing influence of the intranuclear microenvironment

1 reference

12 December 2020

Hsp70 and Hsp40 chaperone activities in the cytoplasm and the nucleus of mammalian cells

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.036335

1 reference

28 July 2017

1 reference

28 July 2017

1 reference