(Q45304513)

11 December 2017

title

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation (English)

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11 December 2017

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11 December 2017

9

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11

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11 December 2017

Tali Gidalevitz

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author name string

Alexandra Zourlidou

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11 December 2017

Mark Kristiansen

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11 December 2017

Christian Landles

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11 December 2017

Ben Woodman

5

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11 December 2017

David S Latchman

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11 December 2017

Jackie de Belleroche

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11 December 2017

Richard I Morimoto

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11 December 2017

language of work or name

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14 March 2007

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11 December 2017

published in

Human Molecular Genetics

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11 December 2017

volume

16

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11 December 2017

issue

9

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11 December 2017

page(s)

1078-1090

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Using advances in neuroimaging to detect, understand, and monitor disease progression in Huntington's disease

11 December 2017

cites work

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

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The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease

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Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

21 January 2018

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Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

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21 January 2018

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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

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Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

21 January 2018

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Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

21 January 2018

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Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

21 January 2018

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Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

21 January 2018

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Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

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Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

21 January 2018

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Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models

21 January 2018

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Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease

21 January 2018

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Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

21 January 2018

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Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease

21 January 2018

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Tryptophan metabolism and oxidative stress in patients with Huntington's disease

21 January 2018

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Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

21 January 2018

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Mitochondrial function and parental sex effect in Huntington's disease

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Mitochondrial defect in Huntington's disease caudate nucleus

21 January 2018

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Complex I defect in muscle from patients with Huntington's disease.

21 January 2018

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Proteomic analysis of protein expression and oxidative modification in r6/2 transgenic mice: a model of Huntington disease

21 January 2018

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Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

21 January 2018

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The neuroprotective effects of heat shock protein 27 overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death

21 January 2018

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Heat shock protein 27 rescues motor neurons following nerve injury and preserves muscle function

21 January 2018

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Standardization and statistical approaches to therapeutic trials in the R6/2 mouse

21 January 2018

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Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease

21 January 2018

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

21 January 2018

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Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

21 January 2018

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Regional and cellular gene expression changes in human Huntington's disease brain

21 January 2018

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Heme oxygenase-2 gene deletion attenuates oxidative stress in neurons exposed to extracellular hemin

21 January 2018

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Selective vulnerability of dopaminergic neurons to microtubule depolymerization

21 January 2018

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Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival

21 January 2018

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Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways

21 January 2018

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Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation.

21 January 2018

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Disassembling protein aggregates in the yeast cytosol. The cooperation of Hsp26 with Ssa1 and Hsp104.

21 January 2018

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A chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation

21 January 2018

1 reference

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Large unphosphorylated aggregates as the active form of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNFalpha in NIH-3T3-ras cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Overexpression of wild-type heat shock protein 27 and a nonphosphorylatable heat shock protein 27 mutant protects against ischemia/reperfusion injury in a transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

The hunt for huntingtin function: interaction partners tell many different stories

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Oxidative stress in skin fibroblasts cultures of patients with Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Increased formation of reactive oxygen species, but no changes in glutathione peroxidase activity, in striata of mice transgenic for the Huntington's disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Progressive disruption of cellular protein folding in models of polyglutamine diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Analysis of molecular masses and oligomeric states of protein complexes by blue native electrophoresis and isolation of membrane protein complexes by two-dimensional native electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM057

21 January 2018

Identifiers

DOI

10.1093/HMG/DDM057

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11 December 2017

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