(Q34114458)

31 July 2017

title

Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease (English)

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31 July 2017

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8

Gen Sobue

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31 July 2017

Masahisa Katsuno

1

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31 July 2017

Chen Sang

2

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31 July 2017

Hiroaki Adachi

3

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31 July 2017

Makoto Minamiyama

4

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31 July 2017

Masahiro Waza

5

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31 July 2017

Fumiaki Tanaka

6

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31 July 2017

Manabu Doyu

7

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31 July 2017

language of work or name

English

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publication date

31 October 2005

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Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

published in

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31 July 2017

volume

102

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31 July 2017

issue

46

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31 July 2017

page(s)

16801-16806

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17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

31 July 2017

cites work

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

28 July 2018

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Spinal and bulbar muscular atrophy: ligand-dependent pathogenesis and therapeutic perspectives

28 July 2018

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Role of heat shock proteins during polyglutamine neurodegeneration: mechanisms and hypothesis

28 July 2018

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Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

28 July 2018

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High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.

28 July 2018

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Polyglutamine protein aggregation and toxicity are linked to the cellular stress response

28 July 2018

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Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

28 July 2018

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Hsp105alpha suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity

28 July 2018

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Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

28 July 2018

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28 July 2018

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Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins.

28 July 2018

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28 July 2018

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28 July 2018

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Protective effect of chaperones on polyglutamine diseases

28 July 2018

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Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

28 July 2018

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Widespread occurrence of intranuclear atrophin-1 accumulation in the central nervous system neurons of patients with dentatorubral-pallidoluysian atrophy

28 July 2018

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Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

28 July 2018

1 reference

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Glutamine repeats and neurodegeneration

28 July 2018

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Heat shock factors and the control of the stress response

28 July 2018

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Androgen receptor mutation in Kennedy's disease

28 July 2018

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Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

28 July 2018

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28 July 2018

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Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait

28 July 2018

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Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

28 July 2018

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Efficient selection for high-expression transfectants with a novel eukaryotic vector

28 July 2018

1 reference

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Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

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Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients.

21 January 2018

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Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

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Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Effects of geranyl-geranyl-acetone administration before heat shock preconditioning for conferring tolerance against ischemia-reperfusion injury in rat livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Single oral dose of geranylgeranylacetone induces heat-shock protein 72 and renders protection against ischemia/reperfusion injury in rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Astroglial activation accompanies heat shock protein upregulation in rat brain following single oral dose of geranylgeranylacetone

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Transgenic mice with an expanded CAG repeat controlled by the human AR promoter show polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Analysis of heat shock transcription factor for suppression of polyglutamine toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0506249102

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

21 January 2018

1 reference

12 December 2020

Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

1 reference

12 December 2020

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

12 December 2020

Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model

1 reference

12 December 2020

X-linked recessive bulbospinal neuronopathy. A clinicopathological study

1 reference

12 December 2020

Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa

1 reference

12 December 2020

Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection

1 reference

12 December 2020

Geranylgeranylacetone induces heat shock protein-73 in rat small intestine

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0506249102

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31 July 2017

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31 July 2017

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