(Q36913508)

17 August 2017

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title

Homocysteine-lowering therapy: a role in stroke prevention? (English)

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17 August 2017

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1

J David Spence

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17 August 2017

1 September 2007

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17 August 2017

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17 August 2017

6

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17 August 2017

830-838

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17 August 2017

9

1 reference

Homocysteine and its disulfide derivatives: a suggested consensus terminology

17 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Metabolic Abnormalities Detected in a Survey of Mentally Backward Individuals in Northern Ireland

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

The identification of homocystine in the urine

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Heterozygosity for Homocystinuria in Premature Peripheral and Cerebral Occlusive Arterial Disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Hyperhomocysteinemia: an independent risk factor for vascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Genetic modulation of homocysteinemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Effect of Usual Doses of Folate Supplementation on Elevated Plasma Homocyst(e)ine in Hemodialysis Patients: No Difference between 1 and 5 mg Daily

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Drugs affecting homocysteine metabolism: impact on cardiovascular risk

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Effect of drugs on homocysteine concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Antioxidant activity of vitamin B6 delays homocysteine-induced atherosclerosis in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Increased monocyte adhesion to aortic endothelium in rats with hyperhomocysteinemia: role of chemokine and adhesion molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

TDAG51 Is Induced by Homocysteine, Promotes Detachment-mediated Programmed Cell Death, and Contributes to the Development of Atherosclerosis in Hyperhomocysteinemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Plasma homocysteine levels and mortality in patients with coronary artery disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine lowering with folic acid and B vitamins in vascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine lowering and cardiovascular events after acute myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine and stroke: evidence on a causal link from mendelian randomisation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Plasma homocyst(e)ine concentration, but not MTHFR genotype, is associated with variation in carotid plaque area

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Mechanisms of thrombosis in hyperhomocysteinemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine and thrombosis: from basic science to clinical evidence

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Methionine-induced elevation of plasma homocysteine concentration is associated with an increase of plasma cholesterol in adult rats

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine induces 3-hydroxy-3-methylglutaryl coenzyme a reductase in vascular endothelial cells: a mechanism for development of atherosclerosis?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Biological chemistry of thiols in the vasculature and in vascular-related disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocyst(e)ine induces calcium second messenger in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine upregulates vascular cell adhesion molecule-1 expression in cultured human aortic endothelial cells and enhances monocyte adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine-induced endothelin-1 release is dependent on hyperglycaemia and reactive oxygen species production in bovine aortic endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine-induced decrease in endothelin-1 production is initiated at the extracellular level and involves oxidative products

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Acute hyperhomocysteinaemia and endothelial dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Hyperhomocysteinemia and endothelial function in young subjects: effects of vitamin supplementation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Folate improves endothelial function in patients with coronary heart disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Acetylcysteine reduces plasma homocysteine concentration and improves pulse pressure and endothelial function in patients with end-stage renal failure

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Mechanisms of the atherogenic effects of elevated homocysteine in experimental models.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Targeting of metallothionein by L-homocysteine: a novel mechanism for disruption of zinc and redox homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteinylation of metallothionein impairs intracellular redox homeostasis: the enemy within!

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Thrombophilia testing in patients with venous thrombosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Ocular venous occlusion and hyperhomocysteinemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine, vitamin B6 and the risk of recurrent venous thromboembolism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Primary upper-extremity deep vein thrombosis: high prevalence of thrombophilic defects

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Effects of homocysteine thiol group on fibrin networks: another possible mechanism of harm

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Culprit factors for the failure of well-conducted warfarin therapy to prevent ischemic events in patients with atrial fibrillation: the role of homocysteine

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Changes in plasma homocyst(e)ine in the acute phase after stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Fluctuations in blood lipid levels during furosemide therapy: a randomized, double-blind, placebo-controlled crossover study.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Vitamins and progression of atherosclerosis in hyper-homocyst(e)inaemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

What level of plasma homocyst(e)ine should be treated? Effects of vitamin therapy on progression of carotid atherosclerosis in patients with homocyst(e)ine levels above and below 14 μmol/L

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Effect of homocysteine-lowering vitamin treatment on electrocardiography stress tests in a randomized, placebo-controlled trial: comparison between ST-segment changes and Athen QRS-score

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Vitamin supplementation reduces the progression of atherosclerosis in hyperhomocysteinemic renal-transplant recipients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Decreased rate of coronary restenosis after lowering of plasma homocysteine levels

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Folate therapy and in-stent restenosis after coronary stenting

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Vitamin Intervention for Stroke Prevention (VISP) trial: rationale and design.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Vitamin Intervention For Stroke Prevention trial: an efficacy analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocysteine trials--clear outcomes for complex reasons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Efficacy of folic acid supplementation in stroke prevention: a meta-analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Vitamin B12 (cobalamin) deficiency in elderly patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

HOLOTRANSCOBALAMIN II LEVELS IN PLASMA ARE RELATED TO DEMENTIA IN OLDER PEOPLE

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Holotranscobalamin - a sensitive marker of cobalamin malabsorption

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

The effect of folic acid fortification on plasma folate and total homocysteine concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Nutrition and Stroke Prevention

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

The vegetarian lifestyle and DNA methylation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

The impact on eating habits of temporary translocation from a Mediterranean to a Northern European environment

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Hyperhomocysteinemia and cobalamin deficiency in young Asian Indians in the United States

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Facts and recommendations about total homocysteine determinations: an expert opinion

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Dimercaptosuccinic acid for the treatment of hyperhomocysteinemia in hemodialysis patients: a placebo-controlled, double-blind, randomized trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Thiol exchange: An in vitro assay that predicts the efficacy of novel homocysteine lowering therapies

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

The Effect of Mesna on Plasma Total Homocysteine Concentration in Hemodialysis Patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Is plasma homocysteine a modifiable risk factor for stroke?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

Homocyst(e)ine and stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

The many facets of hyperhomocysteinemia: studies from the Framingham cohorts

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2807%2970219-3

7 January 2021

10.1016/S1474-4422(07)70219-3

Identifiers

DOI

1 reference

17 August 2017

1 reference

PubMed ID

17706567