(Q36916904)

17 August 2017

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title

Pharmacogenetics as a tool for optimising drug therapy in solid-organ transplantation (English)

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ORCID Public Data File 2021

17 August 2017

organ transplantation

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1 reference

author name string

Fu Liang Ng

series ordinal

1

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17 August 2017

David W Holt

series ordinal

2

1 reference

17 August 2017

Iain A M MacPhee

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

1 September 2007

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Expert Opinion on Pharmacotherapy

17 August 2017

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17 August 2017

8

1 reference

17 August 2017

13

1 reference

17 August 2017

2045-2058

1 reference

Does pharmacogenetics have the potential to allow the individualisation of immunosuppressive drug dosing in organ transplantation?

17 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

The pharmacogenetics of immunosuppression for organ transplantation: a route to individualization of drug administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Pharmacogenomics of immunosuppressive drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

The pharmacogenetics of calcineurin inhibitors: one step closer toward individualized immunosuppression?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Genetic variability in CYP3A5 and its possible consequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Organ transplantation--how much of the promise has been realized?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Immunosuppressive drugs for kidney transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Clinical utility of monitoring tacrolimus blood concentrations in liver transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Therapeutic drug monitoring of sirolimus: correlations with efficacy and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Adequate early cyclosporin exposure is critical to prevent renal allograft rejection: patients monitored by absorption profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

The natural history of chronic allograft nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

New-Onset Diabetes After Transplantation 2003 International Consensus Guidelines: an endocrinologist's view.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Posttransplantation diabetes mellitus in FK-506-treated renal transplant recipients: analysis of incidence and risk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Therapeutic drug monitoring of immunosuppressive drugs in kidney transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Absorption profiling of cyclosporine microemulsion (neoral) during the first 2 weeks after renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Abbreviated tacrolimus area-under-the-curve monitoring for renal transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

AUC-guided dosing of tacrolimus prevents progressive systemic overexposure in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Frequency of cytochrome P450 3A4 variant genotype in transplant population and lack of association with cyclosporin clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Association of the CYP3A4*1B 5'-flanking region polymorphism with cyclosporine pharmacokinetics in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Genotype relationships in the CYP3A locus in Caucasians

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and P-glycoprotein correlate with dose requirement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Tacrolimus pharmacogenetics: the CYP3A5*1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Tacrolimus Dosing in Pediatric Heart Transplant Patients is Related to CYP3A5 and MDR1 Gene Polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Influence of CYP3A5 and MDR1 (ABCB1) polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Tacrolimus dosing in adult lung transplant patients is related to cytochrome P4503A5 gene polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Genetic polymorphisms of CYP3A5 genes and concentration of the cyclosporine and tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Influence of CYP3A5 and MDR1 polymorphisms on tacrolimus concentration in the early stage after renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Sirolimus and tacrolimus trough concentrations and dose requirements after kidney transplantation in relation to CYP3A5 and MDR1 polymorphisms and steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Impact of CYP3A5 and MDR1(ABCB1) C3435T polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Influence of different allelic variants of the CYP3A and ABCB1 genes on the tacrolimus pharmacokinetic profile of Chinese renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

MDR1 haplotypes derived from exons 21 and 26 do not affect the steady-state pharmacokinetics of tacrolimus in renal transplant patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

The effect of variable CYP3A5 expression on cyclosporine dosing, blood pressure and long-term graft survival in renal transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

CYP3A5 polymorphism and the ethnic differences in cyclosporine pharmacokinetics in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

CYP3A5*3 influences sirolimus oral clearance in de novo and stable renal transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Genetically determined differences in P-glycoprotein function: implications for disease risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

MDR1 genotype-related pharmacokinetics: fact or fiction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

A "silent" polymorphism in the MDR1 gene changes substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Redundancy of biological regulation as the basis of emergence of multidrug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Intestinal MDR1/ABCB1 level at surgery as a risk factor of acute cellular rejection in living-donor liver transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Impact of ABCB1 (MDR1) haplotypes on tacrolimus dosing in adult lung transplant patients who are CYP3A5 *3/*3 non-expressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

MDR-1 C3435T polymorphism influences cyclosporine a dose requirement in liver-transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

MDR1 haplotypes do not affect the steady-state pharmacokinetics of cyclosporine in renal transplant patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Amlodipine, but not MDR1 polymorphisms, alters the pharmacokinetics of cyclosporine A in Japanese kidney transplant recipients1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

C3435T mutation in exon 26 of the human MDR1 gene and cyclosporine pharmacokinetics in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Liver regeneration in recipients and donors after transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Auxiliary partial orthotopic living donor liver transplantation as an aid for small-for-size grafts in larger recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Sequential analysis of tacrolimus dosing in adult lung transplant patients with ABCB1 haplotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Pharmacokinetic interaction between corticosteroids and tacrolimus after renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Calcineurin inhibitor-induced nephrotoxicity and renal expression of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Clinical and genetic risk factors for posttransplant diabetes mellitus in adult renal transplant recipients treated with tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Therapeutic drug monitoring of sirolimus: effect of concomitant immunosuppressive therapy and optimization of drug dosing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

P-glycoprotein (P-gp) is upregulated in peripheral T-cell subsets from solid organ transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

CYP3A5 and ABCB1 Polymorphisms and Tacrolimus Pharmacokinetics in Renal Transplant Candidates: Guidelines from an Experimental Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

The influence of CYP3A gene polymorphisms on cyclosporine dose requirement in renal allograft recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.8.13.2045

10.1517/14656566.8.13.2045

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference