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Redundancy of biological regulation as the basis of emergence of multidrug resistance.
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scholarly article
1 reference
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Europe PubMed Central
PubMed ID
16164965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16164965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
review article
1 reference
stated in
Europe PubMed Central
title
Redundancy of biological regulation as the basis of emergence of multidrug resistance
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
16164965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16164965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
main subject
multiple drug resistance
1 reference
based on heuristic
inferred from title
author
Alexander A. Shtil
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
16164965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16164965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
author name string
Janeen Azare
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
16164965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16164965%20AND%20SRC:MED&resulttype=core&format=json
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6 January 2020
publication date
1 January 2005
1 reference
stated in
Europe PubMed Central
PubMed ID
16164965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16164965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
published in
International Review of Cytology
1 reference
stated in
Europe PubMed Central
PubMed ID
16164965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16164965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
volume
246
1 reference
stated in
Europe PubMed Central
PubMed ID
16164965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16164965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
page(s)
1-29
1 reference
stated in
Europe PubMed Central
PubMed ID
16164965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16164965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
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Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun
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Structure of A23187, a divalent cation ionophore
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Effect of mitogen-activated protein kinase signal transduction pathway on multidrug resistance induced by vincristine in gastric cancer cell line MGC803.
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Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway
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Structure and expression of the human MDR (P-glycoprotein) gene family
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NF-kappaB inhibits apoptosis in murine mammary epithelia
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PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages
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Phosphatidylcholine and cell death
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Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C.
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Control of histone modifications
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P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries
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Demethylation of the human MDR1 5' region accompanies activation of P-glycoprotein expression in a HL60 multidrug resistant subline
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Cross-talk between signalling pathways and the multidrug resistant protein MDR-1
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Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)
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A bird's eye view of global methylation
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FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.
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Methylation analysis of the human multidrug resistance 1 gene in normal and leukemic hematopoietic cells
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Regulation of RANTES chemokine gene expression requires cooperativity between NF-kappa B and IFN-regulatory factor transcription factors
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Akt in prostate cancer: possible role in androgen-independence
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NF-kappa B and Rel: participants in a multiform transcriptional regulatory system.
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Functions of sphingolipids and sphingolipid breakdown products in cellular regulation
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7 January 2021
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Identification and characterization of a family of mammalian methyl-CpG binding proteins
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The ubiquitin system
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7 January 2021
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Structure of the multidrug resistance P-glycoprotein
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Protein kinase C isozymes as potential targets for anticancer therapy
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Antitumor effect of a novel nuclear factor-kappa B activation inhibitor in bladder cancer cells
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NF-kappaB activation by camptothecin. A linkage between nuclear DNA damage and cytoplasmic signaling events
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Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-kappa B and inhibition of Bcl-xl expression.
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Protein kinase C isoenzymes: divergence in signal transduction?
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Differential utilization of multiple transcription start points accompanies the overexpression of the P-glycoprotein-encoding gene in Chinese hamster lung cells
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MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism
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Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y.
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7 January 2021
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The regulation of AP-1 activity by mitogen-activated protein kinases
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7 January 2021
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How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex
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A 'molecular switchboard'--covalent modifications to proteins and their impact on transcription
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Activation of purified human protein kinase C alpha and beta I isoenzymes in vitro by Ca2+, phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate
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Inhibition of NF-kappa B by sodium salicylate and aspirin
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Signal transducer and activator of transcription-3 and phosphatidylinositol-3 kinase as coordinate regulators of melanoma cell response to glucocorticoid hormones.
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Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling
1 reference
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Association of 5' CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in human cancer cells
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c-Jun NH2-terminal kinase inhibitor anthra(1,9-cd)pyrazol-6(2H)-one reduces inducible nitric-oxide synthase expression by destabilizing mRNA in activated macrophages
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Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
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Activation of interleukin-6 gene expression through the NF-kappa B transcription factor
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12-O-tetradecanoylphorbol-13-acetate activation of the MDR1 promoter is mediated by EGR1
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7 January 2021
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P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity
1 reference
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7 January 2021
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NF-kappaB as a primary regulator of the stress response
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7 January 2021
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Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor.
1 reference
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7 January 2021
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Protein kinase C: structure, function, and regulation
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7 January 2021
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Use of fluorescent dyes as molecular probes for the study of multidrug resistance
1 reference
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7 January 2021
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Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
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7 January 2021
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Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals
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STI571 as a targeted therapy for CML.
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7 January 2021
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Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region
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Identification and characterization of the MDR1 promoter-enhancing factor 1 (MEF1) in the multidrug resistant HL60/VCR human acute myeloid leukemia cell line
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7 January 2021
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Caveolin interaction with protein kinase C. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide.
1 reference
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7 January 2021
based on heuristic
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Role of the stress-activated/c-Jun NH2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phorbol ester induced MDR1 expression in K562 cells occurs independently of mitogen-activated protein kinase signaling pathways
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7 January 2021
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inferred from DOI database lookup
Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks
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7 January 2021
based on heuristic
inferred from DOI database lookup
The AU-rich 3' untranslated region of human MDR1 mRNA is an inefficient mRNA destabilizer
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7 January 2021
based on heuristic
inferred from DOI database lookup
Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression
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7 January 2021
based on heuristic
inferred from DOI database lookup
Coupling endoplasmic reticulum stress to the cell death program
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of extracellular-signal regulated kinases 1/2 is required for apoptosis of human colon cancer cells in vitro by sulindac metabolites
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https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF-kappaB activation pathways induced by T cell costimulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular alterations associated with LNCaP cell progression to androgen independence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential effects of the MDR1 (multidrug resistance) gene-activating agents on protein kinase C: evidence for redundancy of mechanisms of acquired MDR in leukemia cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signal transduction pathways and transcriptional mechanisms as targets for prevention of emergence of multidrug resistance in human cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multifactorial drug resistance: P-glycoprotein on the apex of the pyramid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase C
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of Raf as a result of recruitment to the plasma membrane
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The language of covalent histone modifications
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Histone acetylation and transcriptional regulatory mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA demethylation and cancer: therapeutic implications.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular target-based cancer therapy: tyrosine kinase inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Androgen receptor: a key molecule in the progression of prostate cancer to hormone independence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The calcium mobilizing tumor promoting agent, thapsigargin elevates the platelet cytoplasmic free calcium concentration to a higher steady state level. A possible mechanism of action for the tumor promotion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of glutathione-S-transferase in anti-cancer drug resistance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Diacylglycerol--when is it an intracellular messenger?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
60-Hz electric fields inhibit protein kinase C activity and multidrug resistance gene (MDR1) up-regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of protein kinase C function induces an apoptotic response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase CbetaII activation by 1-beta-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2alpha down-regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The protein kinase C family
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian methyltransferases and methyl-CpG-binding domains: proteins involved in DNA methylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Promoter-region hypermethylation and gene silencing in human cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0074-7696%2805%2946001-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0074-7696(05)46001-5
1 reference
stated in
Europe PubMed Central
PubMed ID
16164965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16164965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
PubMed ID
16164965
1 reference
stated in
Europe PubMed Central
PubMed ID
16164965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16164965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 January 2020
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