(Q36944628)

17 August 2017

Cystinosin is a Component of the Vacuolar H+-ATPase-Ragulator-Rag Complex Controlling Mammalian Target of Rapamycin Complex 1 Signaling (English)

1 reference

17 August 2017

1 reference

Corinne Antignac

10

0 references

author name string

Zuzanna Andrzejewska

1

1 reference

17 August 2017

Nathalie Nevo

2

1 reference

17 August 2017

Lucie Thomas

3

1 reference

17 August 2017

Cerina Chhuon

4

1 reference

17 August 2017

Anne Bailleux

5

1 reference

17 August 2017

Véronique Chauvet

6

1 reference

17 August 2017

Pierre J Courtoy

7

1 reference

17 August 2017

Marie Chol

8

1 reference

17 August 2017

Ida Chiara Guerrera

9

1 reference

17 August 2017

8 October 2015

1 reference

Journal of the American Society of Nephrology

17 August 2017

1 reference

17 August 2017

27

1 reference

17 August 2017

6

1 reference

17 August 2017

1678-1688

1 reference

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Time course of pathogenic and adaptation mechanisms in cystinotic mouse kidneys

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Possible links between stress defense and the tricarboxylic acid (TCA) cycle in Francisella pathogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Regulation of mTORC1 and its impact on gene expression at a glance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

RRAG GTPases link nutrient availability to gene expression, autophagy and lysosomal biogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Current and emerging therapies for the lysosomal storage disorders

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

ERS1 encodes a functional homologue of the human lysosomal cystine transporter

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Molecular pathogenesis of cystinosis: effect of CTNS mutations on the transport activity and subcellular localization of cystinosin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

The tetraspanin CD63 enhances the internalization of the H,K-ATPase beta-subunit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Intralysosomal cystine accumulation in mice lacking cystinosin, the protein defective in cystinosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Morphological and functional characterization of a conditionally immortalized collecting tubule cell line.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

A third-generation lentivirus vector with a conditional packaging system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

A conditionally immortalized cell line from murine proximal tubule

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

V-ATPase/mTOR signaling regulates megalin-mediated apical endocytosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Dedifferentiation and aberrations of the endolysosomal compartment characterize the early stage of nephropathic cystinosis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Infantile cystinosis: a reappraisal of early and late symptoms.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4884097

Cysteamine restores glutathione redox status in cultured cystinotic proximal tubular epithelial cells

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26449607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cysteamine therapy delays the progression of nephropathic cystinosis in late adolescents and adults

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26449607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Approval of cysteamine for patients with cystinosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26449607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1681/ASN.2014090937

1 reference

17 August 2017

1 reference

17 August 2017

1 reference