(Q36949086)

English

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor

scientific article published on 22 June 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

positron emission tomography

1 reference

based on heuristic

inferred from title

Marion Bankstahl

object named as

Marion Bankstahl

5

0 references

Severin Mairinger

object named as

Severin Mairinger

7

0 references

Claudia Kuntner

object named as

Claudia Kuntner

2

0 references

object named as

Oliver Langer

12

0 references

author name string

Florian Bauer

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Jens P Bankstahl

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Thomas Wanek

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Johann Stanek

6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Bernd Dörner

8

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Wolfgang Löscher

9

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Markus Müller

10

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Thomas Erker

11

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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publication date

22 June 2010

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Bioorganic & Medicinal Chemistry

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

18

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

15

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

5489-5497

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

Targeting multidrug resistance in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

Drug resistance in brain diseases and the role of drug efflux transporters.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

29 September 2017

Rational use of in vitro P-glycoprotein assays in drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

27 June 2018

The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

27 June 2018

Synthesis and evaluation of [11C]XR9576 to assess the function of drug efflux transporters using PET.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

4 September 2018

Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

4 September 2018

Synthesis and preclinical evaluation of novel PET probes for P-glycoprotein function and expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

4 September 2018

An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

4 September 2018

Tariquidar, a selective P-glycoprotein inhibitor, does not potentiate loperamide's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

4 September 2018

Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

4 September 2018

P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

4 September 2018

Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

4 September 2018

Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

4 September 2018

Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

4 September 2018

Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

4 September 2018

Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3690440

4 September 2018

Communication between multiple drug binding sites on P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/20621487

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug binding sites on P-glycoprotein are altered by ATP binding prior to nucleotide hydrolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20621487

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple synthesis of [11C]methyl triflate

1 reference

https://pubmed.ncbi.nlm.nih.gov/20621487

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting proteins in vivo: in vitro guidelines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20621487

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/20621487

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BMC.2010.06.057

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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