(Q36956235)

17 August 2017

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title

Design of selective nuclear receptor modulators: RAR and RXR as a case study (English)

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17 August 2017

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ChEBI release 2020-05-28

William Bourguet

2

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Hinrich Gronemeyer

object named as

Hinrich Gronemeyer

series ordinal

4

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Lucia Altucci

object named as

Lucia Altucci

series ordinal

3

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Angel R de Lera

object named as

Angel R de Lera

series ordinal

1

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publication date

1 October 2007

1 reference

Nature Reviews Drug Discovery

17 August 2017

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17 August 2017

6

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17 August 2017

10

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17 August 2017

811-820

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https://scigraph.springernature.com/pub.10.1038/nrd2398

17 August 2017

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cites work

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Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain.

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31 March 2020

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31 March 2020

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Coregulator function: a key to understanding tissue specificity of selective receptor modulators

31 March 2020

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Transcriptional regulation by steroid receptor coactivator phosphorylation

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Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains

31 March 2020

1 reference

A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers

31 March 2020

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Separation of retinoid X receptor homo- and heterodimerization functions

31 March 2020

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Co-regulator recruitment and the mechanism of retinoic acid receptor synergy

31 March 2020

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Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors

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Signature of the oligomeric behaviour of nuclear receptors at the sequence and structural level

31 March 2020

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Structural determinants of allosteric ligand activation in RXR heterodimers.

31 March 2020

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Allosteric control of ligand selectivity between estrogen receptors alpha and beta: implications for other nuclear receptors

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Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions

31 March 2020

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Rational design of RAR-selective ligands revealed by RARbeta crystal structure

31 March 2020

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Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists

31 March 2020

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Conformational adaptation of agonists to the human nuclear receptor RAR gamma

31 March 2020

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Activation of mammalian retinoid X receptors by the insect growth regulator methoprene

31 March 2020

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Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR

31 March 2020

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Phytanic acid is a retinoid X receptor ligand

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Serine 232 and methionine 272 define the ligand binding pocket in retinoic acid receptor subtypes

31 March 2020

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Structural basis for isotype selectivity of the human retinoic acid nuclear receptor

31 March 2020

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Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma

31 March 2020

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Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes

31 March 2020

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Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells

31 March 2020

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4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists

31 March 2020

1 reference

Induction of apoptosis by retinoids and retinoic acid receptor gamma-selective compounds in mouse thymocytes through a novel apoptosis pathway

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD2398

1 reference

PubMed ID

17906643

Dimensions Publication ID

17 August 2017

0 references

1 reference

PubMed ID

17906643