(Q36965883)

English

S 50131 and S 51434, two novel small molecule glucokinase activators, lack chronic efficacy despite potent acute antihyperglycaemic activity in diabetic mice

scientific article published on July 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

S 50131 and S 51434, two novel small molecule glucokinase activators, lack chronic efficacy despite potent acute antihyperglycaemic activity in diabetic mice (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Frédéric De Ceuninck

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Catherine Kargar

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Yves Charton

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Solo Goldstein

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Françoise Perron-Sierra

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Catherine Ilic

6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Audrey Caliez

7

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Jean-Olivier Rolin

8

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Marjorie Sadlo

9

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Elizabeth Harley

10

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Cédric Vinson

11

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Alain Ktorza

12

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

language of work or name

0 references

publication date

1 July 2013

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

British Journal of Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

169

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

999-1010

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Small molecular glucokinase activators: has another new anti-diabetic therapeutic lost favour?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Novel pharmacological approaches to the treatment of type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Effects of MK-0941, a novel glucokinase activator, on glycemic control in insulin-treated patients with type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Management of type 2 diabetes: new and future developments in treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Lipids, lipid-lowering therapy and diabetes complications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Animal research: reporting in vivo experiments: the ARRIVE guidelines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Fatty acids and insulin resistance in muscle and liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Rapid assessment of drug metabolism in the drug discovery process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Effect of fatty acids on glucose production and utilization in man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Pancreatic islet glucose metabolism and regulation of insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Phosphorylation of glucose in isolated rat hepatocytes. Sigmoidal kinetics explained by the activity of glucokinase alone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Chapter 4 Preparation of Isolated Rat Liver Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

29 September 2017

Chronic glucokinase activation reduces glycaemia and improves glucose tolerance in high-fat diet fed mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

27 June 2018

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

27 June 2018

Improved metabolic disorders of insulin receptor-deficient mice by transgenic overexpression of glucokinase in the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

27 June 2018

Differences in signaling properties of the cytoplasmic domains of the insulin receptor and insulin-like growth factor receptor in 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

27 June 2018

Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

27 June 2018

Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

4 September 2018

Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

4 September 2018

Hepatic glucokinase expression is associated with lipogenesis and fatty liver in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

4 September 2018

A small-molecule glucokinase activator lowers blood glucose in the sulfonylurea-desensitized rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

4 September 2018

Targeting hepatic glucokinase in type 2 diabetes: weighing the benefits and risks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

4 September 2018

Heterogeneity in disease severity in a family with a novel G68V GCK activating mutation causing persistent hyperinsulinaemic hypoglycaemia of infancy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

4 September 2018

Design of a potent, soluble glucokinase activator with excellent in vivo efficacy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

4 September 2018

A novel glucokinase activator modulates pancreatic islet and hepatocyte function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

4 September 2018

Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

4 September 2018

Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

4 September 2018

Allosteric activators of glucokinase: potential role in diabetes therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

4 September 2018

Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3696324

4 September 2018

Diabetic dyslipidemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23488540

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of hypertension among diabetic patients and its relation to vascular risk. Diabetes Hypertension Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/23488540

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man--fact or myth

1 reference

https://pubmed.ncbi.nlm.nih.gov/23488540

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/BPH.12172

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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