(Q36970728)

17 August 2017

1 reference

title

Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression (English)

1 reference

17 August 2017

0 references

1 reference

2

Gordon B Mills

1 reference

17 August 2017

Mandi Murph

1

1 reference

17 August 2017

15 October 2007

1 reference

Expert Reviews in Molecular Medicine

17 August 2017

1 reference

17 August 2017

9

1 reference

17 August 2017

1-18

1 reference

17 August 2017

28

1 reference

Biological functions of a novel lipid mediator, cyclic phosphatidic acid

17 August 2017

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

Autotaxin expression in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

LPA-induced epithelial ovarian cancer (EOC) in vitro invasion and migration are mediated by VEGF receptor-2 (VEGF-R2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

Lysophosphatidic acid as an autocrine and paracrine mediator

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

Lysophosphatidic acid synthesis and release

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

Phosphonothioate and fluoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Phase I and pharmacokinetic study of weekly NV06 (Phenoxodiol), a novel isoflav-3-ene, in patients with advanced cancer

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Sphingosine 1-phosphate analogs as receptor antagonists

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Phase I trial of phenoxodiol delivered by continuous intravenous infusion in patients with solid cancer

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Synthesis and SAR studies of a novel class of S1P1 receptor antagonists

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Identification of Darmstoff analogs as selective agonists and antagonists of lysophosphatidic acid receptors

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Synthesis of chiral (alpha,alpha-difluoroalkyl)phosphonate analogues of (lyso)phosphatidic acid via hydrolytic kinetic resolution.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Pharmacophore-based design of sphingosine 1-phosphate-3 receptor antagonists that include a 3,4-dialkoxybenzophenone scaffold.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

S-15183a and b, New Sphingosine Kinase Inhibitors, Produced by a Fungus.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Identifying specific conformations by using a carbohydrate scaffold: discovery of subtype-selective LPA-receptor agonists and an antagonist

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA).

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Antitumor activity of sphingosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Plasma lysophosphatidic acid concentration and ovarian cancer

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Malignant effusions contain lysophosphatidic acid (LPA)-like activity

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Characterization of B-5354c, a new sphingosine kinase inhibitor, produced by a marine bacterium

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Sphingosine 1-phosphate receptor expression profile and regulation of migration in human thyroid cancer cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Expression of the endothelial cell differentiation gene 7 (EDG-7), a lysophosphatidic acid receptor, in ovarian tumor

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

LPA2 receptor mediates mitogenic signals in human colon cancer cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Lysophosphatidic acid, a novel lipid growth factor for human thyroid cells: over-expression of the high-affinity receptor edg4 in differentiated thyroid cancer

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

FTY720 (fingolimod) in renal transplantation.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Erythrocytes store and release sphingosine 1-phosphate in blood.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Existence of a bioactive lipid, cyclic phosphatidic acid, bound to human serum albumin

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Analysis of the mode of action of a novel immunosuppressant FTY720 in mice

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

FGFR4 GLY388 isotype suppresses motility of MDA-MB-231 breast cancer cells by EDG-2 gene repression

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Abnormal serum lysophospholipids in multiple myeloma patients

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

The emerging role of lysophosphatidic acid in cancer

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Over-expression of lysophosphatidic acid receptor-2 in human invasive ductal carcinoma

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Sphingosine kinase-1--a potential therapeutic target in cancer.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

An oncogenic role of sphingosine kinase

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

I want a new drug: G-protein-coupled receptors in drug development

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Quantitative analysis of acyl-lysophosphatidic acid in plasma using negative ionization tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Essential role for sphingosine kinases in neural and vascular development

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Increased production of bioactive lysophosphatidic acid by serum lysophospholipase D in human pregnancy

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Direct quantitative analysis of lysophosphatidic acid molecular species by stable isotope dilution electrospray ionization liquid chromatography-mass spectrometry

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Expression, regulation and function of autotaxin in thyroid carcinomas

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Differential expression of lysophosphatidic acid receptor-2 in intestinal and diffuse type gastric cancer

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

FTY720/cyclosporine regimens in de novo renal transplantation: a 1-year dose-finding study

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Lysophosphatidic acid-operated K+ channels.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Homo- and hetero-dimerization of LPA/S1P receptors, OGR1 and GPR4

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Follicular fluid high density lipoprotein-associated sphingosine 1-phosphate is a novel mediator of ovarian angiogenesis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Immunotherapy for De Novo renal transplantation: what's in the pipeline?

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR).

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Cyclic phosphatidic acid is produced by autotaxin in blood

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Sphingosine-1-phosphate: an enigmatic signalling lipid

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Identification of residues responsible for ligand recognition and regioisomeric selectivity of lysophosphatidic acid receptors expressed in mammalian cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Measurement of lysophospholipase D/autotaxin activity in human serum samples.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000476

7 January 2021

10.1017/S1462399407000476

Identifiers

DOI

0 references

PubMed ID

17935635

1 reference

PubMed ID

17935635