(Q36976154)

English

Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells.

scientific article published on November 2014

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scholarly article

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20 February 2020

Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells (English)

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20 February 2020

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20 February 2020

author name string

Jung-Eun Park

2

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20 February 2020

Dan Lim

3

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20 February 2020

Christopher C Lai

4

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20 February 2020

James A Kelley

5

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20 February 2020

Suk-Youl Park

6

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20 February 2020

Ki Won Lee

7

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20 February 2020

Michael B Yaffe

8

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20 February 2020

Kyung S Lee

9

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20 February 2020

Terrence R Burke

10

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20 February 2020

publication date

1 November 2014

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20 February 2020

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20 February 2020

102

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20 February 2020

6

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20 February 2020

444-455

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20 February 2020

Preparation of orthogonally protected (2S, 3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) as a phosphatase-stable phosphothreonine mimetic and its use in the synthesis of Polo-box domain-binding peptides

1 reference

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29 September 2017

Mechanisms underlying Plk1 polo-box domain-mediated biological processes and their physiological significance

1 reference

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29 September 2017

Exploring the Binding Nature of Pyrrolidine Pocket-Dependent Interactions in the Polo-Box Domain of Polo-Like Kinase 1

1 reference

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29 September 2017

Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1).

1 reference

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29 September 2017

Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position.

1 reference

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29 September 2017

Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.

1 reference

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29 September 2017

Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification

1 reference

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29 September 2017

Investigation of unanticipated alkylation at the N(π) position of a histidyl residue under Mitsunobu conditions and synthesis of orthogonally protected histidine analogues

1 reference

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29 September 2017

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

1 reference

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29 September 2017

PLK1 as an oncology target: current status and future potential

1 reference

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29 September 2017

From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1

1 reference

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29 September 2017

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

1 reference

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29 September 2017

Polo-box domain: a versatile mediator of polo-like kinase function

1 reference

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29 September 2017

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1 reference

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29 September 2017

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

1 reference

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29 September 2017

Phosphopeptide fragmentation and analysis by mass spectrometry

1 reference

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29 September 2017

A pan-specific inhibitor of the polo-box domains of polo-like kinases arrests cancer cells in mitosis

1 reference

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29 September 2017

Polo-like kinases: conservation and divergence in their functions and regulation

1 reference

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29 September 2017

Promiscuous aggregate-based inhibitors promote enzyme unfolding

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29 September 2017

Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition

1 reference

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29 September 2017

In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.

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29 September 2017

HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes

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29 September 2017

Polo-like kinases: a team in control of the division

1 reference

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29 September 2017

Progress in the discovery of polo-like kinase inhibitors.

1 reference

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29 September 2017

ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

1 reference

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29 September 2017

Regulation of cell cycle checkpoints by polo-like kinases

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29 September 2017

Structure and function of Polo-like kinases

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29 September 2017

Polo-like kinases, an introduction

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29 September 2017

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29 September 2017

Polo-like kinases and the orchestration of cell division

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29 September 2017

The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex

1 reference

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29 September 2017

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

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29 September 2017

Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells

1 reference

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29 September 2017

Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates

1 reference

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29 September 2017

Functional studies on the role of the C-terminal domain of mammalian polo-like kinase

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29 September 2017

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The balance of Polo-like kinase 1 in tumorigenesis

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4 September 2018

Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions

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4 September 2018

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4 September 2018

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4 September 2018

A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells.

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12 December 2020

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20 February 2020

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24 November 2022

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Europe PubMed Central

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20 February 2020

1 reference

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20 February 2020

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