(Q36293407)

English

Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position.

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scholarly article

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Europe PubMed Central

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6 February 2020

Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position (English)

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6 February 2020

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6 February 2020

author name string

Jung-Eun Park

2

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6 February 2020

Fa Liu

3

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6 February 2020

Kyung S Lee

4

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6 February 2020

Terrence R Burke

5

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6 February 2020

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26 May 2012

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6 February 2020

Bioorganic & Medicinal Chemistry

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6 February 2020

21

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6 February 2020

14

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6 February 2020

3996-4003

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6 February 2020

Preparation of orthogonally protected (2S, 3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) as a phosphatase-stable phosphothreonine mimetic and its use in the synthesis of Polo-box domain-binding peptides

1 reference

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1 reference

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Scapinin-induced inhibition of axon elongation is attenuated by phosphorylation and translocation to the cytoplasm

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Phosphorylation of JDP2 on threonine-148 by the c-Jun N-terminal kinase targets it for proteosomal degradation

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Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

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A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD).

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The natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation

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The alpha,alpha-difluorinated phosphonate L-pSer-analogue: an accessible chemical tool for studying kinase-dependent signal transduction

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Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

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A pan-specific inhibitor of the polo-box domains of polo-like kinases arrests cancer cells in mitosis

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Polo-like kinases: conservation and divergence in their functions and regulation

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Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition

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Principles of protein-protein interactions: what are the preferred ways for proteins to interact?

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In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.

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Progress in the discovery of polo-like kinase inhibitors.

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ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein-protein interactions in signaling cascades

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Protein-protein interaction inhibitors get into the groove

1 reference

https://pubmed.ncbi.nlm.nih.gov/22743087

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based on heuristic

inferred from PubMed ID database lookup

Why an A-loop phospho-mimetic fails to activate PAK1: understanding an inaccessible kinase state by molecular dynamics simulations

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diastereoselective synthesis of 2-amino-4-phosphonobutanoic acids by electrophilic substitution and tin-Peterson olefination of bis-lactim ethers derived from cyclo-[L-AP4-D-Val]

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BMC.2012.05.036

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743087%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743087%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22743087%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

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