(Q36977738)

17 August 2017

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title

The pharmacology of the cannabinoid system--a question of efficacy and selectivity (English)

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17 August 2017

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Christopher J Fowler

1

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17 August 2017

publication date

7 July 2007

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17 August 2017

published in

Molecular Neurobiology

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17 August 2017

volume

36

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17 August 2017

issue

1

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17 August 2017

page(s)

15-25

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https://scigraph.springernature.com/pub.10.1007/s12035-007-0001-6

17 August 2017

exact match

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cites work

Development of the first potent and specific inhibitors of endocannabinoid biosynthesis

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS12035-007-0001-6

A role for endocannabinoids in indomethacin-induced spinal antinociception

21 January 2018

1 reference

12 December 2020

Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

1 reference

12 December 2020

Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?

1 reference

12 December 2020

Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway

1 reference

12 December 2020

Direct inhibition by cannabinoids of human 5-HT3A receptors: probable involvement of an allosteric modulatory site

1 reference

12 December 2020

N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties

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12 December 2020

Oxidative metabolism of endocannabinoids

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12 December 2020

Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro

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12 December 2020

Evidence for novel cannabinoid receptors

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12 December 2020

Anandamide and WIN 55212-2 inhibit cyclic AMP formation through G-protein-coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes.

1 reference

12 December 2020

Brain monoglyceride lipase participating in endocannabinoid inactivation

1 reference

12 December 2020

Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor

1 reference

12 December 2020

The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner

1 reference

12 December 2020

Cannabinoid receptors and pain

1 reference

12 December 2020

The anandamide transport inhibitor AM404 activates vanilloid receptors.

1 reference

12 December 2020

Nonclassical and endogenous cannabinoids: effects on the ordering of brain membranes.

1 reference

12 December 2020

Chemically distinct ligands promote differential CB1 cannabinoid receptor-Gi protein interactions.

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12 December 2020

Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons.

1 reference

12 December 2020

Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity

1 reference

12 December 2020

Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro

1 reference

12 December 2020

Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity

1 reference

12 December 2020

Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis.

1 reference

12 December 2020

The cannabinoid system and its pharmacological manipulation--a review, with emphasis upon the uptake and hydrolysis of anandamide

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12 December 2020

Cannabis, cannabinoids and reproduction

1 reference

12 December 2020

The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications

1 reference

12 December 2020

Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain

1 reference

12 December 2020

Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404 [N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide].

1 reference

12 December 2020

Novel selective and metabolically stable inhibitors of anandamide cellular uptake

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12 December 2020

Acidic Nonsteroidal Anti-inflammatory Drugs Inhibit Rat Brain Fatty Acid Amide Hydrolase in a pH-dependent Manner

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12 December 2020

Cannabinoid receptors as therapeutic targets.

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12 December 2020

Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist

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12 December 2020

Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus

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12 December 2020

Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172.

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12 December 2020

Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide

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12 December 2020

Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand

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12 December 2020

The cannabinoid agonist WIN 55,212-2 inhibits TNF-alpha-induced neutrophil transmigration across ECV304 cells

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12 December 2020

Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol

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12 December 2020

Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase

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12 December 2020

Inverse, protean, and ligand-selective agonism: matters of receptor conformation

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12 December 2020

Sodium channel inhibition by anandamide and synthetic cannabimimetics in brain.

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12 December 2020

Modulation of anxiety through blockade of anandamide hydrolysis

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12 December 2020

Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system

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12 December 2020

Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: evidence for agonist-specific trafficking of intracellular responses.

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12 December 2020

The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum

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12 December 2020

Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase

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12 December 2020

Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

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12 December 2020

A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells.

1 reference

12 December 2020

Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion.

1 reference

12 December 2020

Endocannabinoids in the regulation of appetite and body weight

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12 December 2020

Receptor-independent depression of DA and 5-HT uptake by cannabinoids in rat neocortex--involvement of Na(+)/K(+)-ATPase

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12 December 2020

A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1

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12 December 2020

Selective inhibitors of fatty acid amide hydrolase relative to neuropathy target esterase and acetylcholinesterase: toxicological implications

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12 December 2020

Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport.

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12 December 2020

Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors

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12 December 2020

Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain.

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12 December 2020

The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues

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12 December 2020

CB1- and CB2-cannabinoid receptor-independent lipolysis induced by WIN 55,212-2 in male rat adipocytes

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12 December 2020

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha

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12 December 2020

The potency of the fatty acid amide hydrolase inhibitor URB597 is dependent upon the assay pH.

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12 December 2020

Intrathecally applied flurbiprofen produces an endocannabinoid-dependent antinociception in the rat formalin test

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12 December 2020

Anandamide transport inhibitor AM404 and structurally related compounds inhibit synaptic transmission between rat hippocampal neurons in culture independent of cannabinoid CB1 receptors

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12 December 2020

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics

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12 December 2020

2-Arachidonoylglycerol (2-AG) membrane transport: history and outlook

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12 December 2020

Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus.

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12 December 2020

Gi protein modulation induced by a selective inverse agonist for the peripheral cannabinoid receptor CB2: implication for intracellular signalization cross-regulation

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12 December 2020

Functional role of high-affinity anandamide transport, as revealed by selective inhibition

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12 December 2020

In silico patent searching reveals a new cannabinoid receptor

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12 December 2020

Recent advances in CB1 cannabinoid receptor antagonists.

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12 December 2020

In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?

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12 December 2020

The endocannabinoid system: current pharmacological research and therapeutic possibilities

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12 December 2020

Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action

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12 December 2020

Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors

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12 December 2020

Roles of sulfhydryl and disulfide groups in the binding of CP-55,940 to rat brain cannabinoid receptor

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12 December 2020

Inverse agonism and neutral antagonism at cannabinoid CB1 receptors

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12 December 2020

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

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12 December 2020

Cannabinoid-based drugs as anti-inflammatory therapeutics

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12 December 2020

The endocannabinoid signaling system: pharmacological and therapeutic aspects

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12 December 2020

The endocannabinoid system and its therapeutic exploitation

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12 December 2020

Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons

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12 December 2020

The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors

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12 December 2020

Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716

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12 December 2020

Ibuprofen inhibits rat brain deamidation of anandamide at pharmacologically relevant concentrations. Mode of inhibition and structure-activity relationship.

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12 December 2020

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

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12 December 2020

Endocannabinoids control the induction of cerebellar LTD.

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12 December 2020

Endocannabinoid-mediated short-term synaptic plasticity: depolarization-induced suppression of inhibition (DSI) and depolarization-induced suppression of excitation (DSE)

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12 December 2020

Allosteric modulation of the cannabinoid CB1 receptor

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12 December 2020

AM-404 elevates renal intracellular Ca(2+), questioning its selectivity as a pharmacological tool for investigating the anandamide transporter

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12 December 2020

Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations.

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12 December 2020

Further evidence for the existence of a specific process for the membrane transport of anandamide

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12 December 2020

Early medical use of cannabis

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12 December 2020

Recent developments in cannabinoid ligands

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12 December 2020

Species and strain differences in the expression of a novel glutamate-modulating cannabinoid receptor in the rodent hippocampus.

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12 December 2020

URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain

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12 December 2020

Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents

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12 December 2020

Cannabinoid CB1 receptors control conditioned drug seeking

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12 December 2020

Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes

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12 December 2020

Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease

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12 December 2020

WIN55212-2 docking to the CB1 cannabinoid receptor and multiple pathways for conformational induction

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12 December 2020

Cannabinoids modulate neuronal firing in the rat basolateral amygdala: evidence for CB1- and non-CB1-mediated actions

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12 December 2020

Properties of rat liver N-acylethanolamine amidohydrolase

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12 December 2020

Pharmacological properties and therapeutic possibilities for drugs acting upon endocannabinoid receptors

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12 December 2020

Activation of TRPV1 by the satiety factor oleoylethanolamide

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12 December 2020

Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors

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12 December 2020

Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis.

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12 December 2020

Identification of a high-affinity binding site involved in the transport of endocannabinoids

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12 December 2020

The CB1 cannabinoid receptor can sequester G-proteins, making them unavailable to couple to other receptors

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12 December 2020

Identification of a potent and highly efficacious, yet slowly desensitizing CB1 cannabinoid receptor agonist

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12 December 2020

Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

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12 December 2020

Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice

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12 December 2020

Pharmacological characterization of novel water-soluble cannabinoids

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12 December 2020

Cannabinoids and the immune system: potential for the treatment of inflammatory diseases?

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12 December 2020

An endocannabinoid mechanism for stress-induced analgesia.

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12 December 2020

Reversible, temperature-dependent, and AM404-inhibitable adsorption of anandamide to cell culture wells as a confounding factor in release experiments

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12 December 2020

Evidence for a new G protein-coupled cannabinoid receptor in mouse brain.

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12 December 2020

Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain

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12 December 2020

3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data

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12 December 2020

Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand

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12 December 2020

A biosynthetic pathway for anandamide

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12 December 2020

A FAAH-regulated class of N-acyl taurines that activates TRP ion channels

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12 December 2020

The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide.

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12 December 2020

Cannabinoid receptor homo- and heterodimerization

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12 December 2020

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

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12 December 2020

Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones

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12 December 2020

A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia

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12 December 2020

CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains

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12 December 2020

Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha

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12 December 2020

Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase

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12 December 2020

The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases

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12 December 2020

N-arachidonylethanolamine (anandamide) formation from N-arachidonylphosphatidylethanolamine in rat brain membranes

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12 December 2020

F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist

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12 December 2020

International Union of Pharmacology. XXVII. Classification of cannabinoid receptors

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12 December 2020

Inflammatory mediators convert anandamide into a potent activator of the vanilloid type 1 transient receptor potential receptor in nociceptive primary sensory neurons

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12 December 2020

10.1007/S12035-007-0001-6

Identifiers

DOI

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17 August 2017

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