(Q35876026)

10 August 2017

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title

The endocannabinoid system and its therapeutic exploitation (English)

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10 August 2017

endocannabinoid system

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Maurizio Bifulco

2

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Vincenzo Di Marzo

object named as

Vincenzo Di Marzo

series ordinal

1

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Luciano De Petrocellis

series ordinal

3

object named as

Luciano De Petrocellis

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10 August 2017

1 September 2004

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Nature Reviews Drug Discovery

10 August 2017

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10 August 2017

3

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10 August 2017

771-784

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10 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrd1495

10 August 2017

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cites work

Cannabinoids in clinical practice

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Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

31 March 2020

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Oral morphine and respiratory function amongst hospice inpatients with advanced cancer

31 March 2020

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Structure of a cannabinoid receptor and functional expression of the cloned cDNA

31 March 2020

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Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects

31 March 2020

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Molecular characterization of a peripheral receptor for cannabinoids

31 March 2020

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Anandamide, an endogenous cannabinomimetic eicosanoid: 'killing two birds with one stone'.

31 March 2020

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Isolation and structure of a brain constituent that binds to the cannabinoid receptor

31 March 2020

1 reference

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

31 March 2020

1 reference

2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain

31 March 2020

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CB(1) and CB(2) receptor-mediated signalling: a focus on endocannabinoids

31 March 2020

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31 March 2020

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The molecular logic of endocannabinoid signalling

31 March 2020

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The endocannabinoid system: a general view and latest additions

31 March 2020

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Pharmacology of cannabinoid receptors

31 March 2020

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Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action.

31 March 2020

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Modulation of transmitter release via presynaptic cannabinoid receptors

31 March 2020

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Endocannabinoid signaling in the brain

31 March 2020

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Role of endogenous cannabinoids in synaptic signaling

31 March 2020

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Is cannabinoid transmission involved in rewarding properties of drugs of abuse?

31 March 2020

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It could be habit forming: drugs of abuse and striatal synaptic plasticity.

31 March 2020

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Cannabinoids: a real prospect for pain relief?

31 March 2020

1 reference

Cardiovascular effects of cannabinoids

31 March 2020

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Analysis of the respiratory effects of cannabinoids in rats

31 March 2020

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The role of endocannabinoids in the hypothalamic regulation of visceral function

31 March 2020

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Cannabis, cannabinoids and reproduction

31 March 2020

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The cannabinoid system and immune modulation

31 March 2020

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Cannabinoids and cell fate.

31 March 2020

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CB1 cannabinoid receptors and on-demand defense against excitotoxicity

31 March 2020

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Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol

31 March 2020

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The endogenous cannabinoid system controls extinction of aversive memories

31 March 2020

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Pain modulation by release of the endogenous cannabinoid anandamide

31 March 2020

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Leptin-regulated endocannabinoids are involved in maintaining food intake

31 March 2020

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The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

31 March 2020

1 reference

Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study

31 March 2020

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Increased severity of stroke in CB1 cannabinoid receptor knock-out mice.

31 March 2020

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An endogenous cannabinoid (2-AG) is neuroprotective after brain injury

31 March 2020

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Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism

31 March 2020

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Endocannabinoids control spasticity in a multiple sclerosis model

31 March 2020

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Cannabinoids control spasticity and tremor in a multiple sclerosis model

31 March 2020

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Amnesia induced by beta-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade

31 March 2020

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Striatal cannabinoid CB1 receptor mRNA expression is decreased in the reserpine-treated rat model of Parkinson's disease.

31 March 2020

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Changes in cannabinoid CB(1) receptors in striatal and cortical regions of rats with experimental allergic encephalomyelitis, an animal model of multiple sclerosis

31 March 2020

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Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains

31 March 2020

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Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease

31 March 2020

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Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice

31 March 2020

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Loss of cannabinoid receptors in the substantia nigra in Huntington's disease.

31 March 2020

1 reference

The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells

31 March 2020

1 reference

Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice

31 March 2020

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CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity

31 March 2020

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Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock

31 March 2020

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Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis

31 March 2020

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Endogenous cannabinoids mediate hypotension after experimental myocardial infarction

31 March 2020

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Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation

31 March 2020

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An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice

31 March 2020

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The endocannabinoid system and the molecular basis of paralytic ileus in mice

31 March 2020

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The endogenous cannabinoid system protects against colonic inflammation

31 March 2020

1 reference

Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation

31 March 2020

1 reference

Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage

31 March 2020

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Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer

31 March 2020

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Possible endocannabinoid control of colorectal cancer growth

31 March 2020

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Anandamide and other N-acylethanolamines in human tumors

31 March 2020

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The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation.

31 March 2020

1 reference

Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation

31 March 2020

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Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth

31 March 2020

1 reference

Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors

31 March 2020

1 reference

Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis

31 March 2020

1 reference

The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner

31 March 2020

1 reference

Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system

31 March 2020

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Formation and inactivation of endogenous cannabinoid anandamide in central neurons

31 March 2020

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Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells

31 March 2020

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A second endogenous cannabinoid that modulates long-term potentiation

31 March 2020

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Molecular characterization of a phospholipase D generating anandamide and its congeners

31 March 2020

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Transacylase-mediated and phosphodiesterase-mediated synthesis of N-arachidonoylethanolamine, an endogenous cannabinoid-receptor ligand, in rat brain microsomes. Comparison with synthesis from free arachidonic acid and ethanolamine.

31 March 2020

1 reference

Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain.

31 March 2020

1 reference

Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

31 March 2020

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The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response

31 March 2020

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The endogenous cannabinoid system and brain development

31 March 2020

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Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia

31 March 2020

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Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase

31 March 2020

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A missense mutation in human fatty acid amide hydrolase associated with problem drug use.

31 March 2020

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Further evidence for the existence of a specific process for the membrane transport of anandamide

31 March 2020

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Functional role of high-affinity anandamide transport, as revealed by selective inhibition

31 March 2020

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Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes

31 March 2020

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Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

31 March 2020

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Evidence against the presence of an anandamide transporter

31 March 2020

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Novel selective and metabolically stable inhibitors of anandamide cellular uptake

31 March 2020

1 reference

Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase

31 March 2020

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Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172.

31 March 2020

1 reference

Cellular accumulation of anandamide: consensus and controversy

31 March 2020

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Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

31 March 2020

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Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

31 March 2020

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Modulation of anxiety through blockade of anandamide hydrolysis

31 March 2020

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Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

31 March 2020

1 reference

cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases

31 March 2020

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Brain monoglyceride lipase participating in endocannabinoid inactivation

31 March 2020

1 reference

An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity

31 March 2020

1 reference

HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor

31 March 2020

1 reference

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS

31 March 2020

1 reference

Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease

31 March 2020

1 reference

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

31 March 2020

1 reference

Endocannabinoids as physiological regulators of colonic propulsion in mice

31 March 2020

1 reference

Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret

31 March 2020

1 reference

Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.

31 March 2020

1 reference

Synergistic interactions between cannabinoid and opioid analgesics

31 March 2020

1 reference

The analgesic effect of oral delta-9-tetrahydrocannabinol (THC), morphine, and a THC-morphine combination in healthy subjects under experimental pain conditions

31 March 2020

1 reference

Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide

31 March 2020

1 reference

Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligands

31 March 2020

1 reference

Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors

31 March 2020

1 reference

Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors

31 March 2020

1 reference

Paradoxical pharmacological effects of deoxy-tetrahydrocannabinol analogs lacking high CB1 receptor affinity

31 March 2020

1 reference

Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630

31 March 2020

1 reference

3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): a novel cannabinoid Cb1/Cb2 receptor partial agonist with antihyperalgesic and antiallodynic effects

31 March 2020

1 reference

A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms

31 March 2020

1 reference

Ajulemic acid (CT3): a potent analog of the acid metabolites of THC.

31 March 2020

1 reference

A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis

31 March 2020

1 reference

Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide

31 March 2020

1 reference

Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker

31 March 2020

1 reference

Activation and Binding of Peroxisome Proliferator-Activated Receptor γ by Synthetic Cannabinoid Ajulemic Acid

31 March 2020

1 reference

BAY 38-7271: a novel highly selective and highly potent cannabinoid receptor agonist for the treatment of traumatic brain injury.

31 March 2020

1 reference

O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties

31 March 2020

1 reference

Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial

31 March 2020

1 reference

Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial.

31 March 2020

1 reference

Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study

31 March 2020

1 reference

Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystonia

31 March 2020

1 reference

The synthetic cannabinoid WIN55212-2 decreases the intraocular pressure in human glaucoma resistant to conventional therapies

31 March 2020

1 reference

Lack of analgesic efficacy of oral delta-9-tetrahydrocannabinol in postoperative pain

31 March 2020

1 reference

Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial

31 March 2020

1 reference

Non-acute (residual) neurocognitive effects of cannabis use: a meta-analytic study

31 March 2020

1 reference

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review

31 March 2020

1 reference

Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial

31 March 2020

1 reference

Dexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trial

31 March 2020

1 reference

Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages

31 March 2020

1 reference

Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability

31 March 2020

1 reference

Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling

31 March 2020

1 reference

2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor

31 March 2020

1 reference

Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor

31 March 2020

1 reference

An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors

31 March 2020

1 reference

Discovery and characterization of endogenous cannabinoids

31 March 2020

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Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.

31 March 2020

1 reference

Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease

31 March 2020

1 reference

7 January 2021

Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells

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7 January 2021

Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion.

1 reference

7 January 2021

Cannabis-based medicines--GW pharmaceuticals: high CBD, high THC, medicinal cannabis--GW pharmaceuticals, THC:CBD

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7 January 2021

Identifiers

DOI

10.1038/NRD1495

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10 August 2017

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PubMed ID

15340387