(Q36803312)

English

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics

scientific article published on March 2005

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scholarly article

1 reference

Europe PubMed Central

16 August 2017

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics (English)

1 reference

Europe PubMed Central

16 August 2017

0 references

1 reference

based on heuristic

inferred from title

Benjamin Cravatt

13

object named as

Benjamin F Cravatt

1 reference

Europe PubMed Central

16 August 2017

William L. Jorgensen

12

object named as

William L Jorgensen

1 reference

Europe PubMed Central

16 August 2017

author name string

Dale L Boger

1

1 reference

Europe PubMed Central

16 August 2017

Hiroshi Miyauchi

2

1 reference

Europe PubMed Central

16 August 2017

Wu Du

3

1 reference

Europe PubMed Central

16 August 2017

Christophe Hardouin

4

1 reference

Europe PubMed Central

16 August 2017

Robert A Fecik

5

1 reference

Europe PubMed Central

16 August 2017

Heng Cheng

6

1 reference

Europe PubMed Central

16 August 2017

Inkyu Hwang

7

1 reference

Europe PubMed Central

16 August 2017

Michael P Hedrick

8

1 reference

Europe PubMed Central

16 August 2017

Donmienne Leung

9

1 reference

Europe PubMed Central

16 August 2017

Orlando Acevedo

10

1 reference

Europe PubMed Central

16 August 2017

Cristiano R W Guimarães

11

1 reference

Europe PubMed Central

16 August 2017

language of work or name

0 references

publication date

1 March 2005

1 reference

Europe PubMed Central

16 August 2017

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

16 August 2017

48

1 reference

Europe PubMed Central

16 August 2017

6

1 reference

Europe PubMed Central

16 August 2017

1849-1856

1 reference

Europe PubMed Central

16 August 2017

Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Modulation of anxiety through blockade of anandamide hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Effect of oleamide on sleep and its relationship to blood pressure, body temperature, and locomotor activity in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Proteins regulating the biosynthesis and inactivation of neuromodulatory fatty acid amides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Pain modulation by release of the endogenous cannabinoid anandamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Cannabimimetic fatty acid derivatives: the anandamide family and other endocannabinoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Discovery and characterization of endogenous cannabinoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Molecular characterization of human and mouse fatty acid amide hydrolases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Chemical characterization of a family of brain lipids that induce sleep

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

N-acylated glycerophospholipids and their derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

29 September 2017

Clarifying the catalytic roles of conserved residues in the amidase signature family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

27 June 2018

Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

27 June 2018

Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

27 June 2018

Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

27 June 2018

Synthesis and characterization of diazomethylarachidonyl ketone: an irreversible inhibitor of N-arachidonylethanolamine amidohydrolase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

27 June 2018

Cannabinoid receptors and their endogenous agonist, anandamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

27 June 2018

Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

5 September 2018

Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

5 September 2018

Comparative analysis of fatty acid amide hydrolase and cb(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

5 September 2018

Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

5 September 2018

alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

5 September 2018

Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492884

5 September 2018

Fatty acid amide hydrolase substrate specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15771430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of arachidonoyl ethanolamide hydrolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15771430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Class IV charge models: A new semiempirical approach in quantum chemistry

1 reference

https://pubmed.ncbi.nlm.nih.gov/15771430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel Inhibitors of Brain, Neuronal, and Basophilic Anandamide Amidohydrolase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15771430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15771430

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM049614V

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

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