(Q36980994)

17 August 2017

Distinct pharmacological effects of inhibitors of signal peptide peptidase and gamma-secretase (English)

1 reference

17 August 2017

Toru Sato

1

1 reference

17 August 2017

Kuppanna Ananda

2

1 reference

17 August 2017

Cathy I Cheng

3

1 reference

17 August 2017

Eric J Suh

4

1 reference

17 August 2017

Saravanakumar Narayanan

5

1 reference

17 August 2017

Michael S Wolfe

6

1 reference

17 August 2017

language of work or name

English

0 references

publication date

1 October 2008

1 reference

Journal of Biological Chemistry

17 August 2017

1 reference

17 August 2017

283

1 reference

17 August 2017

48

1 reference

17 August 2017

33287-33295

1 reference

describes a project that uses

17 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2586255/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Substrate-targeting gamma-secretase modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

At the frontline of Alzheimer's disease treatment: gamma-secretase inhibitor/modulator mechanism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Active gamma-secretase complexes contain only one of each component

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

The gamma-secretase complex: membrane-embedded proteolytic ensemble

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Strategies for disease modification in Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Identification of signal peptide peptidase, a presenilin-type aspartic protease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Naphthyl ketones: a new class of Janus kinase 3 inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Benzophenone photophores in biochemistry.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Structural characteristics of alpha-helical peptide molecules containing Aib residues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Designed Helical Peptides Inhibit an Intramembrane Protease

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586255

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M805670200

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18829463

12 December 2020

inferred from PubMed ID database lookup

Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18829463

12 December 2020

inferred from PubMed ID database lookup

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18829463

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M805670200

1 reference

17 August 2017

1 reference

17 August 2017

1 reference