(Q36983159)

English

The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

scientific article published on September 2008

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scholarly article

1 reference

Europe PubMed Central

17 August 2017

The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression (English)

1 reference

Europe PubMed Central

17 August 2017

0 references

author name string

Chun Kim

1

1 reference

Europe PubMed Central

17 August 2017

Yasuyo Sano

2

1 reference

Europe PubMed Central

17 August 2017

Kristina Todorova

3

1 reference

Europe PubMed Central

17 August 2017

Bradley A Carlson

4

1 reference

Europe PubMed Central

17 August 2017

Luis Arpa

5

1 reference

Europe PubMed Central

17 August 2017

Antonio Celada

6

1 reference

Europe PubMed Central

17 August 2017

Toby Lawrence

7

1 reference

Europe PubMed Central

17 August 2017

Kinya Otsu

8

1 reference

Europe PubMed Central

17 August 2017

Janice L Brissette

9

1 reference

Europe PubMed Central

17 August 2017

J Simon C Arthur

10

1 reference

Europe PubMed Central

17 August 2017

Jin Mo Park

11

1 reference

Europe PubMed Central

17 August 2017

language of work or name

0 references

publication date

1 September 2008

1 reference

Europe PubMed Central

17 August 2017

Nature Immunology

1 reference

Europe PubMed Central

17 August 2017

9

1 reference

Europe PubMed Central

17 August 2017

1019-1027

1 reference

Europe PubMed Central

17 August 2017

9

1 reference

Europe PubMed Central

17 August 2017

https://scigraph.springernature.com/pub.10.1038/ni.1640

0 references

A quantitative analysis of kinase inhibitor selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

The many paths to p38 mitogen-activated protein kinase activation in the immune system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Generation and characterization of p38beta (MAPK11) gene-targeted mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Potential adverse effects associated with inhibition of p38alpha/beta MAP kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Activation and signaling of the p38 MAP kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Feedback control of the protein kinase TAK1 by SAPK2a/p38

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

HIF-1alpha is essential for myeloid cell-mediated inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

29 September 2017

Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

27 June 2018

IKKalpha controls formation of the epidermis independently of NF-kappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

27 June 2018

Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

27 June 2018

Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

27 June 2018

p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

4 September 2018

IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

4 September 2018

Essential role of MAPK phosphatase-1 in the negative control of innate immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

4 September 2018

Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

4 September 2018

Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

4 September 2018

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

4 September 2018

Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

4 September 2018

p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

4 December 2018

Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2587092

4 December 2018

Resolution of cutaneous inflammation after local elimination of macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/18677317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18677317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages

1 reference

https://pubmed.ncbi.nlm.nih.gov/18677317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18677317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/NI.1640

1 reference

Europe PubMed Central

17 August 2017

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0 references

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

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