(Q36993537)

English

Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole

scientific article published on 13 October 2008

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scholarly article

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Europe PubMed Central

PMC publication ID

17 August 2017

Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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Adele M Lehane

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Kiaran Kirk

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publication date

13 October 2008

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

PMC publication ID

17 August 2017

52

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

4374-4380

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Genome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

29 September 2017

Quinoline-resistance reversing agents for the malaria parasite Plasmodium falciparum

1 reference

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29 September 2017

PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.

1 reference

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29 September 2017

Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76T marker associated with cessation of chloroquine use against P. falciparum malaria in Hainan, People's Republic of China

1 reference

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29 September 2017

Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance

1 reference

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29 September 2017

pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum

1 reference

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29 September 2017

The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

29 September 2017

Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs

1 reference

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29 September 2017

pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines

1 reference

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29 September 2017

Recovery of chloroquine sensitivity and low prevalence of the Plasmodium falciparum chloroquine resistance transporter gene mutation K76T following the discontinuance of chloroquine use in Malawi

1 reference

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29 September 2017

Lysosomes and drug resistance in malaria

1 reference

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29 September 2017

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

29 September 2017

Distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole pH.

1 reference

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29 September 2017

The public health impact of chloroquine resistance in Africa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

29 September 2017

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

29 September 2017

The structure of malaria pigment beta-haematin

1 reference

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29 September 2017

Hemoglobin metabolism in the malaria parasite Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

29 September 2017

The antimalarial mode of action of chloroquine

1 reference

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29 September 2017

Antimalarials increase vesicle pH in Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

29 September 2017

Susceptibility of human malaria parasites to chloroquine is pH dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

29 September 2017

Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

29 September 2017

A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

27 June 2018

Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

27 June 2018

Quantitative pH measurements in Plasmodium falciparum-infected erythrocytes using pHluorin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

27 June 2018

Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

27 June 2018

The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

27 June 2018

Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

27 June 2018

A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

27 June 2018

Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

27 June 2018

The principal chloroquine resistance protein of Plasmodium falciparum is a member of the drug/metabolite transporter superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

27 June 2018

Trans stimulation provides evidence for a drug efflux carrier as the mechanism of chloroquine resistance in Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

27 June 2018

Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

27 June 2018

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

27 June 2018

Role for the plasmodium falciparum digestive vacuole in chloroquine resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

27 June 2018

Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa

1 reference

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27 June 2018

Hemoglobin catabolism and the killing of intraerythrocytic Plasmodium falciparum by chloroquine

1 reference

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27 June 2018

Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine

1 reference

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27 June 2018

Plasmodium falciparum in Owl Monkeys: Drug Resistance and Chloroquine Binding Capacity

1 reference

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27 June 2018

Reversal of chloroquine resistance in Plasmodium falciparum by verapamil

1 reference

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27 June 2018

Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.

1 reference

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27 June 2018

Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross

1 reference

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27 June 2018

Acid extrusion from the intraerythrocytic malaria parasite is not via a Na(+)/H(+) exchanger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

4 September 2018

Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum

1 reference

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4 September 2018

Plasmodium falciparum strain GC-03 exhibits hyper-gametocytogenesis in partially hemoglobin depleted red blood cells

1 reference

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4 September 2018

Site-directed mutation of arginine 282 to glutamate uncouples the movement of peptides and protons by the rabbit proton-peptide cotransporter PepT1.

1 reference

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4 September 2018

Acidification of the malaria parasite's digestive vacuole by a H+-ATPase and a H+-pyrophosphatase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2592892

4 September 2018

Illumination of the malaria parasite Plasmodium falciparum alters intracellular pH. Implications for live cell imaging

1 reference

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4 September 2018

Identifiers

10.1128/AAC.00666-08

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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